A5085871306- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Plant Molecular Biology Research
- T-cell and B-cell Immunology
- Immune cells in cancer
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
IRCCS Ospedale San Raffaele
2022
University of Milan
2018
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2018
Vita-Salute San Raffaele University
2017-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2018
Stem memory T cells (Tscm) constitute the earliest developmental stage of cells, displaying stem cell–like properties, such as self-renewal capacity. Their superior immune reconstitution potential has sparked interest in cancer therapy, vaccine development, and reconstitution, whereas their role autoimmunity is largely unexplored. Here we show that autoreactive CD8+ Tscm specific for β-cell antigens GAD65, insulin, IGRP are present patients with type 1 diabetes (T1D). In vitro, generation...
Cornelia de Lange syndrome (CdLS), which is reported to affect ∼1 in 10 000 30 newborns, a multisystem organ developmental disorder with relatively mild severe effects. Among others, intellectual disability represents an important feature of this condition. CdLS can result from mutations at least five genes: nipped-B-like protein, structural maintenance chromosomes 1A, 3, RAD21 cohesin complex component and histone deacetylase 8 (HDAC8). It believed that these genes cause by impairing the...
Abstract Autoreactive T cells with the phenotype and function of different memory subsets are present in patients who developed type 1 diabetes (TID). According to progressive differentiation model, generate from naïve precursors a linear unidirectional path depending on strength quality stimulatory signals. By observing human contact GAD65 loaded autologous dendritic cells, we observed that approximately 10% divided plane cell division parallel one immune synapse, causing phenotypic...