A5052638253- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Shoulder Injury and Treatment
- Bone Tumor Diagnosis and Treatments
- Sports injuries and prevention
- CAR-T cell therapy research
- Neuroblastoma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Hippo pathway signaling and YAP/TAZ
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Tendon Structure and Treatment
- Pluripotent Stem Cells Research
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Cardiac tumors and thrombi
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Silk-based biomaterials and applications
Okayama University
2010-2024
Okayama University Hospital
2019-2024
Paired related-homeobox 1 (PRRX1) is a transcription factor in the regulation of developmental morphogenetic processes. There growing evidence that PRRX1 highly expressed certain cancers and critically involved human survival prognosis. However, molecular mechanism cancer malignancy remains to be elucidated.
Paired related homeobox 1 (PRRX1) is a marker of limb bud mesenchymal cells, and deficiency p53 or Rb in Prrx1-positive cells induces osteosarcoma several mouse models. However, the regulatory roles PRRX1 human have not been defined. In this study, we performed immunostaining on 35 specimens to assess correlation between level overall survival. patients with osteosarcoma, expression positively correlated poor prognosis ratio lung metastasis. Additionally, found 143B line high metastatic...
Malignant peripheral nerve sheath tumor (MPNST), a highly malignant that arises in tissues, is known to be resistant radiation and chemotherapy. Although there are several reports on genetic mutations epigenetic changes define the pathogenesis of MPNST, insufficient information regarding microenvironment contributes malignancy MPNST. In present study, we demonstrate adrenaline increases cancer stem cell population This effect mediated by stimulation beta-2 adrenergic receptor (ADRB2), which...
The case of an individual with a bilateral anterior cruciate ligament (ACL) tear combined medial meniscus (MM) posterior root is described. A 34-year-old Japanese man ACL rupture that occurred > 10 years earlier was diagnosed MM (MMPRT). We performed transtibial pullout repair the MMPRT reconstruction. tibial tunnels for and reconstruction were created separately. Postoperatively, good clinical outcome meniscal healing obtained. Our surgical technique may thus contribute to anatomical
Abstract Purpose: Soft tissue sarcomas (STS) are rare and heterogeneous tumors arising from mesenchymal connective tissue, accounting for approximately 1%-2% of all malignancies. Due to their rarity heterogeneity, it is challenging accurate diagnosis, prognosis, treatment sarcoma. Recently, next-generation sequencing (NGS)-based comprehensive cancer genome profiling (CGP) has increasingly become a routine practice patients with solid cancers worldwide. To collect genomic information clinical...
Abstract Background: Paired related-homeobox 1 (PRRX1) is a transcription factor in the regulation of developmental morphogenetic processes. There growing evidence that PRRX1 highly expressed certain cancers and critically involved human survival prognosis. However, molecular mechanism cancer malignancy remains to be elucidated. Methods: expression Malignant peripheral nerve sheath tumors (MPNSTs) samples was detected immunohistochemically evaluate MPNST models with gene knockdown or...
Abstract We aimed to investigate the efficacy and safety of denosumab de-escalation for giant cell tumors bone (GCTB). retrospectively reviewed medical records nine patients with GCTB that were either unresectable or resectable, but not those candidates resection, who received de-escalated treatment at our institution between 2014 2021. The interval was gradually extended every 8 weeks, 12 24 weeks. assessed radiographic changes clinical symptoms during course standard therapy. Denosumab...
The treatment of medial meniscus posterior root tears (MMPRTs) has evolved to include a variety repair strategies. This study investigated the location articular cartilage degeneration during second-look arthroscopy after transtibial pullout with modified Mason-Allen suture using FasT-Fix (F-MMA) in 22 patients MMPRTs. Second-look was performed approximately 1 year postoperatively eval-uate healing status (MM). Articular assessed International Cartilage Repair Society grade at primary...