A5077102052- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Electrochemical Analysis and Applications
- Cell Image Analysis Techniques
- Analytical Chemistry and Sensors
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Disorders and Treatments
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Ion channel regulation and function
- Neurogenesis and neuroplasticity mechanisms
Ruhr University Bochum
2021-2023
Cell culture studies offer the unique possibility to investigate influence of pharmacological treatments with quantified dosages applied for defined time durations on survival, morphological maturation, protein expression and function as well mutual interaction various cell types. Cultures obtained from postnatal rat brain contain a substantial number glial cells that further proliferate in leading an overgrowth neurons glia, especially astrocytes microglia. A well-established method...
Growth cones of oligodendrocyte progenitor cells (OPCs) are challenging to investigate with conventional light microscopy due their small size. Especially substructures such as filopodia, lamellipodia and underlying cytoskeleton difficult resolve diffraction limited microscopy. Light techniques, which surpass the limit stimulated emission depletion microscopy, often require expensive setups specially trained personnel rendering them inaccessible smaller research groups. Lately, invention...
Mice lacking functional thyroid follicular cells, Pax8-/- mice, die early postnatally, making them suitable models for extreme hypothyroidism. We have previously obtained evidence in postnatal rat neurons, that a down-regulation of Na+-current density could explain the reduced excitability nervous system If such mechanism underlies development coma and death severe hypothyroidism, mice should show deficits expression Na+ currents potentially also Na+/K+-ATPases, which are necessary to...