A5014721457- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Genetics and Neurodevelopmental Disorders
- Peripheral Neuropathies and Disorders
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- High Altitude and Hypoxia
- Tryptophan and brain disorders
- Erythropoietin and Anemia Treatment
- Neurogenesis and neuroplasticity mechanisms
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Pluripotent Stem Cells Research
- Asthma and respiratory diseases
- Chemokine receptors and signaling
- Neuroscience and Neuropharmacology Research
- Infectious Encephalopathies and Encephalitis
- Cardiovascular Syncope and Autonomic Disorders
- Cell Image Analysis Techniques
- Myofascial pain diagnosis and treatment
- Stress Responses and Cortisol
- Traumatic Brain Injury and Neurovascular Disturbances
Ludwig-Maximilians-Universität München
2024-2025
Max Planck Institute for Multidisciplinary Sciences
2022-2024
LMU Klinikum
2024
Ruhr University Bochum
2022
Max Planck Institute of Experimental Medicine
2020-2021
Deutsche Bahn (Germany)
2020
University Hospital Schleswig-Holstein
2009
University of Lübeck
2009
Circulating autoantibodies (AB) against brain-antigens, often deemed pathological, receive increasing attention. We assessed predispositions and seroprevalence/characteristics of 49 AB in > 7000 individuals.Exploratory cross-sectional cohort study, investigating deeply phenotyped neuropsychiatric patients healthy individuals GRAS Data Collection for presence/characteristics brain-directed serum-AB. Predispositions were evaluated through GWAS NMDAR1-AB carriers, analyses immune check-point...
Background: Mild traumatic brain injury (mTBI) in the pediatric population is a significant public health concern, often associated with persistent post-concussion symptoms, including postural instability. Current tools for assessing control, such as Balance Error Scoring System (BESS), lack integration objective metrics. Incorporating force plate sensors into BESS assessments may enhance diagnostic accuracy and support return-to-play or sports decisions. This study evaluates performance...
Abstract The etiology and pathogenesis of “anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis” the role autoantibodies (AB) in this condition are still obscure. While NMDAR1-AB exert NMDAR-antagonistic properties by receptor internalization, no firm evidence exists to date that themselves induce brain inflammation/encephalitis. all immunoglobulin classes highly frequent across mammals with multiple possible inducers boosters. We hypothesized “NMDAR results from any primary inflammation...
Abstract Hypoxia is more and perceived as pivotal physiological driving force, allowing cells in the brain elsewhere to acclimate lowered oxygen (O 2 ), abridged metabolism. The mediating transcription program induced by inspiratory hypoxia but also intensive motor‐cognitive tasks, provoking a relative decrease O relation acutely augmented requirement. We termed this fundamental, demand‐dependent drop availability “functional hypoxia.” Major players response are hypoxia‐inducible factors...
Abstract Encephalitis has an estimated prevalence of ≤0.01%. Even with extensive diagnostic work-up, infectious etiology is identified or suspected in <50% cases, suggesting a role for etiologically unclear, noninfectious processes. Mild encephalitis runs frequently unnoticed, despite slight neuroinflammation detectable postmortem many neuropsychiatric illnesses. A widely unexplored field humans, though clearly documented rodents, genetic brain inflammation, particularly that associated...
Cell culture studies offer the unique possibility to investigate influence of pharmacological treatments with quantified dosages applied for defined time durations on survival, morphological maturation, protein expression and function as well mutual interaction various cell types. Cultures obtained from postnatal rat brain contain a substantial number glial cells that further proliferate in leading an overgrowth neurons glia, especially astrocytes microglia. A well-established method...
Soluble immune receptors (SIRs) have been proposed as biomarkers in patients with atopic dermatitis (AD). However, their clinical applicability affected children has rarely studied.To assess the diagnostic usefulness of serum SIRs childhood AD by correlating obtained receptor profiles serological parameters and features such age, phenotype disease severity.We investigated 100 AD. The sCD14, sCD23, sCD25, sCD30, total IgE (tIgE) eosinophilic cationic protein (ECP) were determined using sera...
Abstract Up to one person in a population of 10,000 is diagnosed once lifetime with an encephalitis, 50–70% unknown origin. Recognized causes amount 20–50% viral infections. Approximately third affected subjects develops moderate and severe subsequent damage. Several neurotropic viruses can directly infect pyramidal neurons induce neuronal death cortex hippocampus. The resulting encephalitic syndromes are frequently associated cognitive deterioration dementia, but involve numerous parallel...
The concentration of various immunoglobulins in the faucial tonsil was determined and expressed as a portion total protein content. highest levels were those IgG. IgA rises with age while that IgM falls. IgE found to be relatively high all examined noted hypertrophied tonsils. They lowest atrophic tonsils children adult results are discussed their relevance overall immunological function tonsil.
In the rapidly evolving field of rodent behavior research, observer-independent methods facilitate data collection within a social, stress-reduced, and thus more natural environment. A prevalent system in this research area is IntelliCage, which empowers experimenters to design individual tasks higher cognitive challenges for mice, driven by their motivation access reward. The extensive amount diversity provided IntelliCage explains growing demand automated analysis among users. Here, we...
Background/Purpose: Migraine, tension-type- (TTH), and posttraumatic headache (PTH) are frequently associated with impairments in postural control (PC) due to alterations the integration of visual, proprioceptive, vestibular cues. This study aims investigate compare PC children migraine, TTH, PTH against a healthy group (CG), examining role sensory inputs these disorders utilizing instrumented posturography.
Zusammenfassung Wie schon der römische Gott des Anfangs und Endes, Janus, könnten auch Antikörper (AB) gegen N-Methyl-D-aspartatrezeptoren (NMDAR) zwei Gesichter besitzen duale Effekte vermitteln, wenn sie Zugang zum zentralen Nervensystem erhalten. In den letzten Jahren rückten Autoantikörper die obligatorische NMDAR-Untereinheit GluN1 zunehmend in Fokus von Ärzten, da GuN1-Antikörper (GluN1-AB) Cerebrospinalflüssigkeit als diagnostisches Kriterium für sogenannte anti-NMDAR-Enzephalitis...