A5037386450- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Pain Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Chronic Lymphocytic Leukemia Research
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Genomics and Diagnostics
- Osteoarthritis Treatment and Mechanisms
- Fatty Acid Research and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Chemokine receptors and signaling
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Sphingolipid Metabolism and Signaling
- PI3K/AKT/mTOR signaling in cancer
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
University College Birmingham
2024-2025
University of Birmingham
2019-2025
Queen Mary University of London
2019-2024
William Harvey Research Institute
2019-2024
Versus Arthritis
2022
Medawar Building for Pathogen Research
2018
University College London
2018
University of Calabria
2014-2016
Accumulation of lactate in the tissue microenvironment is a feature both inflammatory disease and cancer. Here, we assess response immune cells to context chronic inflammation. We report that accumulation inflamed contributes upregulation transporter SLC5A12 by human CD4+ T cells. SLC5A12-mediated uptake into induces reshaping their effector phenotype, resulting increased IL17 production via nuclear PKM2/STAT3 enhanced fatty acid synthesis. It also leads cell retention as consequence reduced...
Abstract Background Osteoarthritis (OA), a multifaceted condition, poses significant challenge for the successful clinical development of therapeutics due to heterogeneity. However, classifying molecular endotypes OA pathogenesis could provide invaluable phenotype‐directed routes stratifying subgroups patients targeted therapeutics, leading greater chances success in trials. This study establishes soft joint tissue driven by obesity both load‐bearing and non‐load bearing joints. Methods...
Adaptive immunity contributes to the pathogenesis of cardiovascular metabolic disorders (CVMD). The omega-3 polyunsaturated fatty acids (n-3PUFA) are beneficial for health, with potential improve dysregulated adaptive immune responses associated imbalance. We aimed explore mechanisms through which n-3PUFA may alter T cell motility and tissue distribution promote a less inflammatory environment lymphocyte function in CVMD.
Changes in cellular metabolism have been implicated mediating the activated fibroblast phenotype a number of chronic inflammatory disorders, including pulmonary fibrosis, renal disease and rheumatoid arthritis. The aim this study was therefore to characterise metabolic profile synovial joint fluid fibroblasts under both basal conditions cohort obese normal-weight hip OA patients. Furthermore, we sought ascertain whether modulation pathway could alter their activity. Synovium obtained from...
Abstract Atherosclerosis is a complex inflammatory disease characterized by the accumulation of lipids and immune cells in arterial wall, leading to narrowing stiffening blood vessels. The involvement both innate adaptive immunity pathogenesis human atherosclerosis increasingly recognised. However, spatial organization specific roles during various stages progression remain poorly understood, underscoring necessity for additional research elucidate their functions throughout course. A better...
Silencing key neurons with botulinum toxin conjugates exerts long-lasting pain relief in mouse models of chronic pain.
Repurposing the macrolide antibiotic azithromycin has recently been suggested as a promising neuroprotective strategy for acute treatment of ischemic stroke. Here, we aim at further characterizing immunomodulatory properties intraperitoneal (i.p.) administration this drug and, more importantly, assessing whether neuroprotection can also be achieved by clinically relevant intravenous (i.v.) route in mouse model focal cerebral ischemia induced transient (30-min) middle artery occlusion (MCAo)....
Western diet (WD), high in sugar and fat, promotes obesity associated chronic low-grade pro-inflammatory environment, leading to impaired immune function, reprogramming of innate adaptive cells, development degenerative diseases, including cardiovascular disease. Increased concentrations circulating tissue ceramides contribute inflammation cellular dysfunction common metabolic cardiometabolic Therefore, ceramide-lowering interventions have been considered as strategies improve adipose...
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D) is a potent regulator immune function, promoting anti-inflammatory, tolerogenic T cell responses by modulating antigen presentation dendritic cells (DC). Transcriptomic analyses indicate that DC to 1,25D involve changes in glycolysis, oxidative phosphorylation, electron transport and the TCA cycle. To determine functional impact 1,25D-mediated metabolic remodelling, human monocyte-derived were differentiated immature (+vehicle,...