A5021288918- Phytochemistry Medicinal Plant Applications
- Agricultural and Food Sciences
- Bee Products Chemical Analysis
- Coffee research and impacts
- Microencapsulation and Drying Processes
- Nanoparticle-Based Drug Delivery
- Essential Oils and Antimicrobial Activity
- Curcumin's Biomedical Applications
- Pesticide Residue Analysis and Safety
- Psidium guajava Extracts and Applications
- Pomegranate: compositions and health benefits
- Bioactive Natural Diterpenoids Research
- Psychoanalysis and Psychopathology Research
- Heavy Metals in Plants
- African Studies and Ethnography
- Youth, Drugs, and Violence
- Analytical chemistry methods development
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Phytochemical compounds biological activities
- Pharmacological Effects of Medicinal Plants
- Wound Healing and Treatments
- Phytochemistry and Bioactivity Studies
- Ginkgo biloba and Cashew Applications
- Nail Diseases and Treatments
Universidade Estadual de Ponta Grossa
2015-2023
Universidade Estadual de Maringá
2009-2015
Guaraná (Paullinia cupana Kunth, Sapindaceae) is well known for its dietary and pharmaceutical potential, the semipurified extract of guaraná shows antidepressant panicolytic effects. However, low solubility, bioavailability stability limit use as a component agents. Delivery in microparticle form could help to optimize stability. In this study, microparticles containing were obtained by spray-drying technique, using combination maltodextrin gum arabic. The raw materials produced...
Background: As part of the efforts to find natural alternatives for cancer treatment and overcome barriers cellular resistance chemotherapeutic agents, polymeric nanocapsules containing curcumin and/or methotrexate were prepared by an interfacial deposition preformed polymer method. Methods: Physicochemical properties, drug release experiments in vitro cytotoxicity these performed against Calu-3 lung cell line. Results: The colloidal suspensions showed suitable size (287 325 nm), negative...
The Neotropical plant 'guaraná' has been widely used in medicine, cosmetics, and industry because of its versatile biological activities. These effects are mainly attributed to the presence polyphenols. An efficient, precise, reliable method was developed for quantification polyphenols catechin epicatechin guaraná extract solution, using HPLC-PDA detection. ideal conditions analysis a semipurified (EPA), solutions 0.05% TFA-water (phase A) TFA acetonitrile:methanol (75:25, vv(-1)) B) as...
In southern Brazil, the bottled latex of Synadenium grantii Hook f., Euphorbiaceae, is popularly used as a treatment all types cancer. Similarly, umbellatum Pax. in central western region Brazil for same purpose and manner use. Both plants are known janaúba or leitosinha. The objectives this study were to use pharmacobotanical analysis verify whether these two species, which considered be distinct, actually determine anatomical markers; assist identification differentiation other Euphorbia;...
The objective of this study was to investigate the effects chronic administration a semi-purified extract (Purified Extract A--PEA; 4, 8, or 16 mg/kg) PAULLINIA CUPANA (guaraná) seeds on rats submitted elevated T-maze (ETM) model generalized anxiety and panic disorders. selective serotonin (5-HT) reuptake inhibitor (SSRI) paroxetine (PAR; 3 mg/kg), used as positive control. To evaluate possible serotonergic dopaminergic neurotransmission involvement in action PEA during ETM test, ineffective...
Paullinia cupana (Guarana) is a native plant of Amazon region that has very traditional importance. Its seeds are rich in bioactive compounds, including tannins, which exhibit relevant properties. Objective. This study aimed to evaluate antibacterial, antineoplastic, and immunomodulatory activity P. crude extract (CE) ethyl-acetate fraction (EAF). Methods. Antibacterial was evaluated by determination minimal inhibitory concentration (MIC) bactericidal (MBC). Antineoplastic MTT assays...
The phenolic compounds are the main phytochemical constituents of bark Trichilia catigua and commonly used for medicinal purposes. An HPLC method simultaneous quantification (procyanidin B2 (PB2), epicatechin (EPC), chinchonains Ia, Ib, IIa, IIb, catechin, chrologenic acid) in T. extract was developed validated. A suitable chromatographic system selected, which uses a gradient elution with methanol/ACN (75:25), water both 0.05% TFA, as mobile phase, column Luna, 280 nm, flow 0.4 mL/min....
This study evaluated the technological feasibility of producing a semipurii ed extract guaraná (Paullinia cupana Kunth, Sapindaceae) in tablet form, using direct- compression process. Maltodextrin and gum arabic were used to produce microparticles, order protect microparticles against such factors as temperature, oxidation, humidity. Using pharmacopoeial methodologies, physicochemistry tests (determination residual moisture, bulk tapped density, Hausner ratio, compressibility compactibility...
Miconazole nitrate has been widely employed in treatment of oral mycoses, however your immediate bio-availability and location the affected area is critical.The aim this study was to prepare evaluate Eudragit® L100 Gantrez MS-955 microparticles containing miconazole for delivery.Microparticles were prepared by spray-drying method achieve high encapsulation efficiency increase drug solubility. The formed 10% 20% on polymer (E10 E20), (G10 G20) or their combination (EG10 EG20). influence...
Ilex paraguariensis (yerba-mate) is used as a beverage, and its extract requires adequate quality control methods in order to guarantee safe use.Strategies develop optimize chromatographic method quantify theobromine, caffeine, chlorogenic acid I. extracts were evaluated by applying design (QbD) model ultra high-performance liquid chromatography (UHPLC).The presence of these three phytochemical markers the was using UHPLC-MS confirmed bands total ion current traces (m/z 181.1 [M+H] + , 195.0...
Curcumin (CUR) shows potential use for treating cancer. However, CUR has low solubility and reduced bioavailability, which limit its clinical effect. Therefore, the development of nanocarriers can overcome these problems ensure desired pharmacological In addition, it is mandatory to prove quality, efficacy, safety a novel nanomedicine be approved. that sense, this paper aimed (a) prepare CUR-loaded polyethylene glycol-poly(ε-caprolactone) nanocapsules; (b) validate an analytical method by...
Introduction: Guaraná is well-known for its dietary and pharmaceutical potential the semipurified extract of (EPA) show antidepressant panicolytic effects [1 – 2]. However, their low solubility, bioavailability stability limit use as components agents. For drug delivery, EPA in a micro/nanoparticle form desirable optimized stability. Methods: In this study, microparticles produced by spray drying process using combination maltodextrin (MD) arabic gum (AG) coating polymer. The content high...
Guazuma ulmifolia Lam. (Sterculiaceae), popularly known as „Mutamba“, is a tropical-American plant found from Mexico to southern South America. In the popular medicine of several Latin-American countries, it used for treatment burns, diarrhea, inflammations and alopecia. Polysaccharides, epicatechin (EP) procyanidin oligomers, such procyanidins B2 (PB2) B5, three trimers [procyanidin C1; epicatechin-(4β→6)-epicatechin-(4β→8)-epicatechin; epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin] one...
A Assistência Farmacêutica (AF) tem como objetivo principal o medicamento, seu uso racional e a gestão apropriada nos sistemas de saúde, visando ao bem-estar dos usuários serviços. Portanto, é essencial que esteja operacionalizada reconhecida pelos gestores em saúde. O deste estudo identificar os Planos Municipais Saúde (PM) paranaenses AF está inserida nas secretarias caráter exploratório, utilizando levantamento documental bibliográfico. Foram identificados 26 PM. Foi constatado...
Paullinia cupana var. sorbilis (Mart.) Ducke (Sapindaceae), popularly known as „Guaraná“, is a tropical South American plant found in northern Brazil. Guaraná widely used medicine, cosmetics, and industry due to its versatile biological activities, stimulant of the central nervous system (CNS) cases intellectual physical stress, an antidiarrheic, diuretic, antineuralgic agent [1,2]. It has shown antioxidant, anti-amnesia, antidepressive effects animal models [3–7]. These activities are...
Abstract Leonurus japonicus Houtt. is a medicinal plant popular in Brazil as “rubim”, used local folk medicine for several applications an anti‐inflammatory, antioxidant, analgesic, and antimicrobial phytomedicine. The traditional use wound healing related; however, few studies have evaluated the activity. Thus, this study aimed to analyse indication of hydroalcoholic aqueous extracts L. aerial parts rat model. initial chemical characterization was performed using flavonoid quantification...