A5088182398- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Hypothalamic control of reproductive hormones
- COVID-19 Clinical Research Studies
- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- Pharmacology and Obesity Treatment
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Eating Disorders and Behaviors
- Child Nutrition and Feeding Issues
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Hernia repair and management
University of Campania "Luigi Vanvitelli"
2017-2025
Sapienza University of Rome
2021
ORCID
2021
Brescia University
2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Yale University
2017-2020
University of Naples Federico II
2015-2020
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2020
University of Bologna
2020
We conducted a prospective study in large, multiethnic cohort of obese adolescents to characterize clinical and genetic features associated with pediatric nonalcoholic fatty liver (NAFL), the most common cause chronic disease youth. A total 503 were enrolled, including 191 (38.0%) whites, 134 (26.6%) blacks, 178 (35.4%) Hispanics. Participants underwent abdominal magnetic resonance imaging (MRI) quantify hepatic fat fraction (HFF), an oral glucose tolerance test (OGTT) assess insulin...
Increased incidence of central precocious puberty (CPP) after coronavirus infectious disease-19 lockdown has been reported. Our study aims in investigating changes CPP rates and sleep patterns healthy controls.CPP were retrospectively evaluated from April 2020 to 2021. Parents girls diagnosed with during matched controls filled out a questionnaire about disturbances (SDSC questionnaire) schedules.Thirty-five 37 completed the survey. Incidence new cases significantly increased 2020-2021...
Mutations in the imprinted gene MKRN3 have been described as a common genetic cause of idiopathic central precocious puberty (CPP), particular familial cases. However, exact prevalence mutations is unknown. Single nucleotide polymorphisms 2 other genes, DLK1 and KCNK9, associated with age at menarche. We investigated MKRN3, DLK1, KCNK9 genes cohort girls CPP.MKRN3, coding regions were sequenced 60 CPP (familial 23 cases).Three mutations, including new one, found cases (c.1229G>A; p.Cys410Ter...
Non alcoholic fatty liver disease (NAFLD) is a leading cause of damage in childhood, its occurrence influenced by genetic and environmental factors. Recently, the rs626283 polymorphism MBOAT7 gene has been found to be associated with NAFLD adults.
Summary Background PNPLA3 I148M polymorphism has an effect on modulation of estimated glomerular filtration rate (eGFR) in nonobese nondiabetic adults and children with histologically confirmed nonalcoholic fatty liver disease (NAFLD). Objectives The objective the study is to explore impact eGFR obesity without NAFLD. Methods We genotyped 591 patients for polymorphism. Anthropometrical, biochemical, instrumental data were collected. NAFLD was defined by presence ultrasound‐detected steatosis...
Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and weight (LBW), although the literature still lacks a consensus. This study aimed investigate this correlation in cohort of pregnant women over 20 weeks gestation from University Hospital "Maggiore della Carità", Novara, Italy. We assessed levels oral health status through following indexes: Oral Hygiene Index (OHI), Plaque Control Record (PCR), Gingival Bleeding (GBI), Community Treatment Needs...
To date, little is known about correlations between liver dysfunction and circulatory cardiac abnormalities (e.g.,: mitral valve, MV) in patients with chronic disease (CLD). This study aimed to assess a potential parallelism cardiovascular involvement identify the factors associated structural functional MV disorders. Among 995 CLD, 346 were enrolled compared 168 controls without disease. According degree of disease, classified as hepatitis (142) or cirrhosis (Child-A: 70; Child-B: 65;...
ABSTRACT Background: The rs641738 polymorphism in the membrane‐bound O‐acyltransferase domain containing protein 7 ( MBOAT7 ) gene has been associated with increased risk of nonalcoholic fatty liver disease (NAFLD). Objectives: To investigate association between and both hepatic steatosis biochemical markers damage to evaluate potential additive effect this variant I148M patatin‐like phospholipase domain‐containing 3 PNPLA3 rs58542926 transmembrane 6 superfamily member 2 TM6SF2...
Abstract Context Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance (IR) and predicts type 2 diabetes. Currently, it uncertain whether NAFLD may directly cause IR or vice versa. Objective To test the hypothesis that causally related to IR. Design Methods We performed a Mendelian randomization (MR) in 904 obese children/adolescents using an NAFLD-related genetic risk score (GRS) as instrumental variable. assessed by ultrasonography homeostasis model assessment...
Studies examining vitamin D levels in association with childhood obesity usually do not consider the effect of insulin on D-binding protein and calculate unbound, bioavailable D.This study aimed to evaluate a group children 1) concentrations both total 25-hydroxyvitamin fraction, 2) potential role resistance modulating D. Design, Setting, Patients or Other Participants: This was cross-sectional at University Pediatric Department which 63 obese 21 lean controls were enrolled.Total measured,...
The persistence of symptoms after recovery from Coronavirus 2019 (COVID-19) is defined as long COVID, an entity that had occurred among adults but which not yet well characterized in pediatric ages. purpose this work was to present some the data a survey addressed Italian pediatricians concerning impact long-COVID children who recovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. questionnaire designed and pre-tested February 2021 by working group experts...