A5091309402- Human-Animal Interaction Studies
- Veterinary Medicine and Surgery
- Wildlife Ecology and Conservation
- Veterinary Orthopedics and Neurology
- Diet and metabolism studies
- Veterinary Equine Medical Research
- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Paleopathology and ancient diseases
- Osteoarthritis Treatment and Mechanisms
- Yersinia bacterium, plague, ectoparasites research
- Hip disorders and treatments
- Genetics, Aging, and Longevity in Model Organisms
- Forensic Anthropology and Bioarchaeology Studies
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Gut microbiota and health
- Geographies of human-animal interactions
- Parathyroid Disorders and Treatments
- Evolution and Paleontology Studies
- Veterinary Pharmacology and Anesthesia
- Pleistocene-Era Hominins and Archaeology
- Growth Hormone and Insulin-like Growth Factors
- dental development and anomalies
- T-cell and B-cell Immunology
Illinois State Museum
2014-2025
Center for American Archeology
2019-2025
School for Advanced Research
2016-2025
Marine Mammal Center
2016-2022
Pacific Marine Mammal Center
2016-2022
Yahoo (United Kingdom)
2011
Nestlé (Switzerland)
2007-2008
Imperial College London
2007-2008
Nestlé (United States)
2006-2008
University of Utah
2006-2007
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate genetic basis size. First, through genome-wide scan, we identified major quantitative trait locus (QTL) on chromosome 15 influencing variation within single breed. Second, examined 15-megabase interval surrounding QTL small and giant breeds found marked evidence for selective sweep spanning gene (IGF1), encoding...
Abstract Objective —To determine prevalence of radiographic evidence osteoarthritis in 4 diarthrodial joints dogs with restricted feed intake, compared without intake. Design —Paired feeding study. Animals —48 Labrador Retrievers. Procedure —Dogs litters from 7 dams and 2 sires were paired by sex weight within randomly assigned to a control-fed group or limit-fed that received 25% less food than the controlfed group. Radiographic evaluation severity hip, shoulder, elbow, stifle was performed...
Long-term restriction of energy intake without malnutrition is a robust intervention that has been shown to prolong life and delay age-related morbidity. A 1H NMR-based metabonomic strategy was used monitor urinary metabolic profiles throughout the lifetimes control-fed diet-restricted dogs. Urinary trajectories were constructed for each dog, variation found be predominantly influenced by age. excretion creatinine increased with age, reaching maximum between ages 5 9 years declining...
Large populations of free-roaming cats (FRCs) generate ongoing concerns for welfare both individual animals and populations, human public health, viability native wildlife local ecological damage. Managing FRC is a complex task, without universal agreement on best practices. Previous analyses that use simulation modeling tools to evaluate alternative management methods have focused relative efficacy removal (or trap-return, TR), typically involving euthanasia, sterilization...
The domestication of dogs likely occurred in Eurasia by 16,000 years ago, and the initial peopling Americas potentially happened around same time. Dogs were long thought to have accompanied first migrations into Americas, but conclusive evidence for Paleoindian is lacking. In this study, direct dating two from Koster site (Greene County, Illinois) a newly described dog Stilwell II (Pike between 10,190 9,630 cal BP represents earliest confirmed domestic individual burials anywhere world....
To describe effects of lifetime food restriction on causes death and the association between body-mass characteristics time in dogs.Paired-feeding study.48 dogs from 7 litters.Dogs were paired, 1 dog each pair was fed 25% less than its mate 8 weeks age until death. Numerous morphometric physiologic measures obtained at various intervals throughout life. Associations feeding group to evaluated, along with important associated factors such as body composition components insulin-glucose...
SUMMARY Thyroxine (T 4 ), 3,5,3′-triiodothyronine 3 and cortisol frequently are quantified in canine serum or plasma samples to aid the diagnosis of hypothyroidism, hypoadrenocorticism, hyperadrenocorticism. Many laboratories have established reliable references values for concentrations these hormones blood clinically normal animals. However, nonpathologic factors that affect thyroidal adrenocortical secretion may lead misinterpretation test results when individual animals compared with...
Abstract Postreactive morphological alterations of enthesal surfaces, often termed historically and collectively as “enthesitis,” were thought to reflect typical daily activities. Actually, an important real cause altered surfaces is augmentation the osseous base, a physiological reaction. Further, attachments reveal partial-to-complete avulsion dystrophic calcification (ossification) secondary injury, pathological process. Descriptively, suffixes “sis,” “osis,” “asis” (as appropriate...
Abstract We compared acetabular traits among canid and non‐canid museum specimens, using the same pre‐established protocols. hypothesized conserved, intersecting development‐growth insult‐response biology, reflecting morphologically being highly similar across carnivoran taxa. evaluated from dry bone specimens of Vulpes lagopus , vulpes Nyctereutes procyonoides Urocyon cinereoargenteus Canis lupus familiaris latrans . The was done Procyon lotor (Procyonidae), Taxidea taxus (Mustelidae) Lynx...
Abstract In dogs hip joint laxity that can lead to degenerative disease (DJD) is frequent and heritable, providing a genetic model for some aspects of the human disease. We have used Portuguese water (PWDs) identify Quantitative trait loci (QTLs) regulate in joint. A population 286 PWDs, each characterized by ca. 500 molecular markers, was analyzed subluxation as measured Norberg angle, quantitative radiographic measure laxity. significant directed asymmetry observed, such greater observed...
To determine the relationship between caudolateral curvilinear osteophyte (CCO) and osteoarthritis associated with hip dysplasia in dogs.Longitudinal cohort study.48 Labrador Retrievers from 7 litters.In each of 24 sex- size-matched pairs fed same diet, a restricted-fed dog was 25% less than control for life. The dogs' hips were evaluated standard ventrodorsal hip-extended radiographic projection at 16, 30, 52 weeks age then yearly Histologic examination joint tissues performed on 45...
Modeling aging and age-related pathologies presents a substantial analytical challenge given the complexity of gene–environment influences interactions operating on an individual. A top-down systems approach is used to model effects lifelong caloric restriction, which known extend life span in several animal models. The metabolic phenotypes caloric-restricted (CR; n = 24) pair-housed control-fed (CF; Labrador Retriever dogs were investigated by use orthogonal projection latent structures...
Traditional thinking views apparently non-programmed disruptions of aging, which medical science calls geriatric diseases, as separate from 'less harmful' morphological and physiological aging phenotypes that are more universally expected with passage time (loss skin elasticity, graying hair coat, weight gain, increased sleep time, behavioral changes, etc). Late-life disease phenotypes, especially those involving chronic processes, frequently complex very energy-expensive. A process...
SUMMARY Forty-four female American Shorthair cats with inflammatory uterine disease or infertility were evaluated. Data collected included age, month of diagnosis, housing, reproductive history, results bacteriologic culture specimens, serum concentrations estrogen, progesterone, and prolactin histopathologic features the ovaries uterus. Histologically, 19 dominated by active cystic follicles, whereas 25 had luteal-phase ovaries. Of corpora lutea, 20 either recently weaned litters (n = 11)...
A novel model-free statistical approach (self modeling curve resolution, SMCR) has been applied to recover biochemical information from complex overlapping signals in (1)H NMR spectra of blood serum a long-term study caloric restriction (CR) the dog (n = 24 control fed (CF) and n CR animals). new spectroscopic construct, spectrotype, is proposed which subset description or component metabolic phenotype. Characterization profiles according their evolutionary contribution each spectrotype...
Quantitative genetic evaluation of clinical dilated cardiomyopathy (DCM) was conducted in a large cattery with known history. Data showed that clinically affected cats were significantly more interrelated than randomly chosen case-control populations from the same colony. The results this study suggest quantitative inheritance, either interactive or independent nutrition presently unknown factors, is involved feline cardiomyopathy.