A5026571982- Maternal and Perinatal Health Interventions
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 Impact on Reproduction
- Lymphatic System and Diseases
- Protein Kinase Regulation and GTPase Signaling
- Intestinal and Peritoneal Adhesions
- Surgical Sutures and Adhesives
- Telemedicine and Telehealth Implementation
- Systemic Sclerosis and Related Diseases
- Endometrial and Cervical Cancer Treatments
- COVID-19 and healthcare impacts
- Maternal Mental Health During Pregnancy and Postpartum
- Cell death mechanisms and regulation
- Nursing Roles and Practices
- Mobile Health and mHealth Applications
- Endometriosis Research and Treatment
- Cancer-related Molecular Pathways
- Gene Regulatory Network Analysis
- Gynecological conditions and treatments
- Clinical practice guidelines implementation
- Lipoproteins and Cardiovascular Health
- Pregnancy-related medical research
- Cancer survivorship and care
- Intraperitoneal and Appendiceal Malignancies
- PARP inhibition in cancer therapy
Burnet Institute
2021-2024
Deakin University
2023-2024
Minnesota Oncology
2019-2023
The University of Melbourne
2018
Icahn School of Medicine at Mount Sinai
2017
University of Minnesota
2000-2008
Twin Cities Orthopedics
2000
University of Minnesota Medical Center
1996-1999
There is increasing evidence that cell cycle transit potentially lethal, with survival depending on the activation of metabolic pathways which block apoptosis. However, identities those coupling to remain undefined. Here we show eukaryotic translation initiation factor 4E (eIF4E) can mediate both proliferative and signaling. Overexpression eIF4E completely substituted for serum or individual growth factors in preserving viability established NIH 3T3 fibroblasts. An mutant (Ser-53 changed...
We investigated the validity of Gait Outcomes Assessment List (GOAL), as an assessment gait function in children with cerebral palsy (CP).We studied a prospective cohort 105 CP (Gross Motor Function Classification System [GMFCS] levels I-III; 65 males, 40 females; mean [SD] age 11y 11mo [3y 5mo], range 6-20y), who attended over 10-month period. Parents completed GOAL, Functional Mobility Scale (FMS), and Questionnaire (FAQ) during their child's evaluation. Ninety instrumented analysis (IGA)....
Activated Ras has been shown to provide powerful antiapoptotic signals cells through well defined transcriptional and post- translational pathways, whereas control as a mechanism of survival signaling remains unexplored. Here we show direct relationship between assembly the cap-dependent translation initiation apparatus suppression apoptosis by oncogenic <i>in vitro</i> vivo</i>. Decreasing protein synthesis with rapamycin, which is known inhibit translation, increases susceptibility...
Malignant mesothelioma causes profound morbidity and nearly universal mortality that is refractory to conventional treatment with aggressive surgery, radiotherapy, or chemotherapy. We report pharmacologic concentrations of lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor, induced apoptosis in human malignant cell lines. Mesothelioma viability was decreased dose-dependent manner by lovastatin (5 30 μ M). These effects were not reversed exogenous growth factors...
Background: Yishun Health (YH), a regional population health system under Singapore’s National Healthcare Group expanded its role beyond healthcare provision, to care for more than 330,000 residents in northern Singapore. This prompted transformation towards effective and sustainable Unified Care Model (UCM). YH adopted value-driven strategy, involving needs-based segmentation, segment-specific interventions, systematic measurement, accelerate this integrated transformation. Better...
Background: Medical Home (MH) is a Hospital-at-Home (HaH) service model by Yishun Health (YH) delivering multi-disciplinary care for patients requiring acute medical in their homes. regional hospital system caring 300,000 people the north of Singapore that has embarked on multi-year, whole health transformation to improve outcomes. Care and services delivery enable greater person-centeredness value-driven integration based Unified Model (UCM) its two subsidiary Episodic Lifelong Models. A...
Diseases associated with pathological fibroproliferation represent a major cause of morbidity and mortality. Despite the importance this class disorders, current therapy is limited value, no available to reduce fibroblast population size within existing fibrotic lesions. In regard, constitutive expression growth-promoting genes can sensitize cells undergo apoptosis. Studies in our laboratory have demonstrated that lovastatin potently induces apoptosis fibroblasts constitutively expressing...
Abstract Purpose This paper reports the efficacy of poly (ADP‐ribose) polymerase inhibitor olaparib alone and in combination with antiangiogenesis agent cediranib compared patients advanced endometrial cancer. Methods was open‐label, randomized, phase 2 trial (NCT03660826). Eligible had recurrent cancer, received at least one (<3) prior lines chemotherapy, were Eastern Cooperative Oncology Group performance status 0 to 2. Patients randomly assigned (1:1:1), stratified by histology (serous...
From 2020, COVID-19 spread rapidly around the globe and continues to have a major impact on health system functioning, with disproportionate low- middle-income countries (LMIC). Reduced service utilisation coverage of essential childbirth interventions is likely impacting maternal newborn morbidity mortality. Telehealth has been identified as an important tool in continued provision healthcare services. The aim this study was explore experience implementing telehealth services for remote...
SUMMARY Most cancer cells harbor multiple drivers whose epistasis and interactions with expression context clouds drug sensitivity prediction. We constructed a mechanistic computational model that is context-tailored by omics data to capture regulation of stochastic proliferation death pan-cancer driver pathways. Simulations experiments explore how the coordinated dynamics RAF/MEK/ERK PI-3K/AKT kinase activities in response synergistic mitogen or combinations control cell fate specific...
Objective The aims of this study were to: (1) identify the characteristics patients with chronic hepatitis B (CHB) who do not attend their hospital liver clinic appointments; and (2) raise awareness among general practitioners (GP) alternative pathways to care for CHB in order prevent long-term complications (liver cancer cirrhosis). Methods This prospective was conducted between May 2018 January 2019 at one site a tertiary referral western Melbourne. Patients minimal did first two initial...
Abstract Background Pregnant and postpartum women’s experiences of the COVID-19 pandemic, as well emotional psychosocial impact on perinatal health, has been well-documented across high-income countries. Increased anxiety fear, isolation, a disrupted pregnancy postnatal period are widely described in many studies. The aim this study was to explore, describe synthesise studies that addressed pregnant women countries during first two years pandemic. Methods A qualitative evidence synthesis...
Abstract Background In Australia, maternity care services provide for pregnant and postpartum women their newborns. The COVID-19 pandemic forced these to quickly adapt develop policies procedures dealing with transmission in health facilities, as well work under public measures counter its spread within the community. Despite well-documented responses adaptations by healthcare systems, no studies have examined experiences of service leaders through pandemic. This study aimed explore leaders,...
ABSTRACT From 2020, COVID-19 spread rapidly around the globe and continues to have a major impact on health system functioning, with disproportionate low- middle-income countries (LMIC). Reduced service utilisation coverage of essential childbirth interventions is likely impacting maternal newborn morbidity mortality. Telehealth has been identified as an important tool in continued provision care services. The aim this study was explore experience implementing telehealth services for remote...
Abstract Background Pregnant and postpartum women’s experiences of the COVID-19 pandemic, as well impact on perinatal health, has been well-documented across high-income countries. Increased anxiety fear, isolation, a disrupted pregnancy postnatal period are widely described in many studies. The aim this study was to explore, describe synthesise studies that addressed pregnant women countries during first two years pandemic. Methods A qualitative evidence synthesis (QES) undertaken. Five...