Patients with diabetes are at higher risk for obstructive airway disease (OAD). In recent meta-analyses of post hoc analyses cardiorenal trials, sodium-glucose cotransporter 2 inhibitors (SGLT2Is) were suggested to reduce the OAD adverse events. However, a clinical investigation this association is warranted.This study aimed investigate SGLT2I use vs dipeptidyl peptidase-4 inhibitor (DPP4I) incidence and exacerbation events in patients type diabetes.This retrospective population-based cohort...

Pseudomonas aeruginosa is an important pathogen in patients with chronic respiratory diseases. It can colonize the airway and could have prognostic value bronchiectasis cystic fibrosis. Its role obstructive pulmonary disease (COPD) less well defined. A prospective study was conducted Hong Kong to investigate possible association between colonization acute exacerbation of COPD (AECOPD) risks. Among 327 Chinese included, 33 (10.1%) had colonization. Patients or without similar background...

While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), has been conflicting results from studies on the impact mild-to-moderate COVID-19 control after recovery.A case study association between and post infection was conducted. The primary outcome a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. secondary outcomes included change ACT score, proportion of patient who dropped to ≤ 15 enrolment visit...

While different COVID-19 vaccines have been developed, there has lack of data on the efficacy comparison between mRNA and inactivated whole virus vaccine among patients with chronic respiratory diseases, including asthma, obstructive pulmonary disease (COPD), bronchiectasis.This was a retrospective case control study BNT162b2 (mRNA vaccine) CoronaVac (inactivated against in diseases. A total 327 were included, 109 infected matched 218 without COVID-19. The co-primary outcomes effectiveness...

Abstract Background Elevation of systemic inflammatory markers were found to correlate with increased disease extent, reduced lung function and higher risk future severe exacerbations in patients bronchiectasis. Although a significant correlation circulating hs-CRP levels HRCT scores resting oxygen saturation stable-state non-cystic fibrosis (CF) bronchiectasis was suggested, there is little data on the relationship between prognosis lack role predicting exacerbation. Methods A prospective...

ABSTRACT Introduction Bronchiectasis exacerbation (BE) is associated with unfavorable sequelae in other organs such as the cardiovascular system; data regarding its impact on adverse term renal outcomes, however, lacking. Methods A territory‐wide retrospective cohort study was conducted Hong Kong between 1/1/1993 and 31/12/2017. All patients bronchiectasis followed public healthcare system 2017 were classified “Exacerbators” or “Non‐Exacerbators,” their outcomes (renal progression [decrease...

Hyponatraemia has been suggested to be associated with morbidity and mortality among various medical disorders. Evidence on the association between stable-state hyponatraemia prognosis in patients chronic obstructive pulmonary disease (COPD) is lacking. All COPD followed up a regional hospital year 2015 were included, their clinical outcomes reviewed subsequent eight years. Association was evaluated. Stable-state defined as baseline serum sodium levels, at least 90 days away from last AECOPD...

Abstract Background At the time of Omicron BA.2 outbreak, it was shown that mild to moderate COVID-19 associated with worsening asthma control after recovery. Whether same phenomenon also observed at a later phase pandemic by other variants have not been reported. Methods We conducted follow-up study on patients who received clinical care in Queen Mary Hospital. The were first recruited entitled “Worsening recovery from Hong Kong”. primary outcome test (ACT) score difference among never had...

Chronic obstructive pulmonary disease (COPD) is often exacerbated by various viruses and bacteria, leading to acute episodes of worsening respiratory symptoms, which contribute significantly the morbidity mortality associated with COPD. Consequently, vaccination against these pathogens recommended numerous guidelines safeguard COPD patients from adverse health outcomes. The Global Initiative for Obstructive Lung Disease (GOLD) recommendation advocates influenza, Streptococcus pneumoniae,...

Abstract Background Although blood eosinophil count (BEC) has been extensively studied as a biomarker in chronic obstructive pulmonary disease (COPD), there remain challenges and controversy using single reading. It not determined whether the difference BEC between baseline that during an acute exacerbation of COPD (AECOPD) any role predicting subsequent AECOPD. Methods A prospective study was conducted to investigate possible differences from AECOPD predict future risk. The expressed...

This study aims to investigate the association between elderly patients with COPD different blood eosinophil on admission and those without prognosis of COVID-19. A territory-wide retrospective was conducted Elderly admitted public hospitals community treatment facility in Hong Kong for COVID-19 from January 23, 2020, September 31, 2021, were included study. Severe diseases defined as who develop respiratory complications, systemic complications death. Among 1925 included, 133 had COPD....

Introduction: Chronic obstructive pulmonary disease (COPD) has been reported to have significant healthcare and economic burdens worldwide. Since the COVID-19 pandemic, there changes in epidemiology of various chronic diseases. The burden severe acute exacerbation COPD (AECOPD) factors affecting should be assessed post-pandemic era. Methods: A territory-wide study was conducted Hong Kong AECOPD from 2022 2024, identify associated with an increase direct costs related AECOPD. Adult patients...

Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of decline BOS diagnosis could impact prognostication as a complication HSCT. aim this study was to assess the on overall survival (OS) in subjects.Subjects were compared those without and matched for age, gender, primary diagnoses, conditioning regimes chronic graft versus host disease. Lung tests at baseline, every 3 months HSCT evaluated.Of 1461...

Rationale: Patients with asthma were advised to avoid coronavirus disease (COVID-19) and comply medication during the COVID-19 pandemic. Respiratory tract infection is a common cause of exacerbations. There has not been evidence suggesting link between exacerbation, especially in places dramatic responses control universal masking aggressive social distancing. Objectives: To assess number for admissions exacerbations January April 2020 Hong Kong reference admission past 5 years. Methods:...

While molnupiravir (MOV) and nirmatrelvir–ritonavir (NMV-r) were developed for treatment of mild to moderate COVID-19 infection, there has been a lack data on the efficacy among unvaccinated adult patients with chronic respiratory diseases, including asthma, obstructive pulmonary disease (COPD) bronchiectasis. A territory-wide retrospective cohort study was conducted in Hong Kong investigate MOV NMV-r against severe outcomes diseases. total 3267 included. effective preventing failure (66.6%;...

Introduction: Nirmatrelvir-ritonavir (NMV-r) and molnupiravir (MOL) were developed as out-patient anti-viral for mild COVID-19. There was limited data on their role in treating COVID-19 hospitalized patients, especially among adult patients who are unvaccinated had chronic respiratory diseases. Methods: A territory-wide retrospective study conducted Hong Kong to compare the efficacy of NMV-r MOL against with asthma, obstructive pulmonary disease, bronchiectasis interstitial lung diseases...

Abstract Background Pseudomonas aeruginosa is one of the commonest bacteria colonizing airway in patients with non-cystic fibrosis bronchiectasis. colonization associated poor outcomes bronchiectasis, including rapid decline lung function, exacerbation frequency and hospitalization. Methods A cross-sectional study Queen Mary Hospital, Hong Kong that included 350 Chinese bronchiectasis to investigate risk factors for clinical implications on disease outcomes. Discussions was more commonly...

Electronic health record (EHR) databases can facilitate epidemiology research into various diseases including asthma. Given the diagnostic challenges of asthma, validity coding in EHR requires clarification. We aimed to assess International Classification Diseases, 9th Revision (ICD-9) code algorithms for identifying asthma territory-wide electronic medical system Clinical Data Analysis and Reporting System (CDARS) Hong Kong.Adult patients who had diagnosis input from all public hospitals...

Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association events (CVEs) lacking.

Abstract While studies have suggested increased risks of severe COVID-19 infection in chronic obstructive pulmonary disease (COPD), the persistent and delayed consequences on patients with COPD upon recovery remain unknown. A prospective clinical study was conducted Hong Kong to investigate outcomes who had different severity (mild-moderate COVID-19), compared those did not. Chinese ≥ 40 years old were recruited from March September 2021. They prospectively followed up for 24.9 ± 5.0 months...

Chronic illnesses were reported to be poor prognostic factors associated with severe illness and mortality in Coronavirus disease 2019 (COVID-19) infection. The association asthma, however, is limited controversial, especially for mild asthma.A territory wide retrospective study was conducted investigate the between asthma prognosis of COVID-19. All patients laboratory confirmed Hong Kong COVID-19 from 23 January 30 September 2020 included study. Severe diseases defined as those who develop...

Abstract Accessibility of diagnostic screening and treatment monitoring devices for respiratory diseases is critical in promoting healthcare reducing sudden complications mortality. Spirometry the standard diagnosing several lung diseases. However, it lacks regional assessment capabilities necessary detecting subtle changes certain It also requires challenging breathing maneuvers difficult elderlies, children, diseased patients. Here, we actualized an affordable, portable, self-administrable...

Abstract Background Coronavirus Disease 2019 (COVID-19) led to pandemic that affected almost all countries in the world. Many have implemented border restriction as a public health measure limit local outbreak. However, there is inadequate scientific data support such practice, especially presence of an established transmission disease. Objective To apply metapopulation Susceptible-Exposed-Infectious-Recovered (SEIR) model with inspected migration investigate effect outbreak coronavirus...

The role of inhaled corticosteroid (ICS) among patients with bronchiectasis remains controversial. There is limited evidence using baseline eosinophil count (absolute and percentage) as a marker to predict the ICS bronchiectasis.A retrospective case-control study was conducted in major regional hospital tertiary respiratory referral centre Hong Kong, including 140 Chinese noncystic fibrosis (CF) bronchiectasis, investigate exacerbation risks users nonusers different counts.ICS user had...