A5083059433- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
- Cardiac Fibrosis and Remodeling
- Model-Driven Software Engineering Techniques
- Scientific Computing and Data Management
- Congenital Heart Disease Studies
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Business Process Modeling and Analysis
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Science Education and Pedagogy
- Diversity and Impact of Dance
- Advanced Software Engineering Methodologies
- Literacy, Media, and Education
- Cardiac electrophysiology and arrhythmias
- Educator Training and Historical Pedagogy
- Teacher Education and Leadership Studies
- Liver physiology and pathology
- Animal Genetics and Reproduction
- Cardiac Structural Anomalies and Repair
- Musicians’ Health and Performance
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Diverse Music Education Insights
Medical College of Wisconsin
2019-2024
Nova Southeastern University
2023
Brigham Young University
2023
American Museum of Natural History
2022
Somatic polyploidization, an adaptation by which cells increase their DNA content to support growth, is observed in many cell types, including cardiomyocytes. Although polyploidization believed be beneficial, progression a polyploid state often accompanied loss of proliferative capacity. Recent work suggests that genetics heavily influence cardiomyocyte ploidy. However, the developmental course cardiomyocytes reach final ploidy has only been investigated select backgrounds. Here, we assessed...
In this paper, we explore the stories teachers tell as they study and grapple with culturally responsive education in their science classrooms. This qualitative case focuses primarily on “Stories from Field”, a conversational routine at each professional learning group meeting where shared observations, thoughts, insights about classroom, instruction, school settings context of education. We found that teachers’ first year surfaced themes navigating systemic constraints supports, connecting...
Runx1 is sufficient but not required for cardiomyocyte cell cycle.
Abstract Background Recent advances in single cell sequencing have led to an increased focus on the role of cell-type composition phenotypic presentation and disease progression. Cell-type research heart is challenging due large, frequently multinucleated cardiomyocytes that preclude most approaches from obtaining accurate measurements composition. Our silico studies reveal ignoring type when calculating differentially expressed genes (DEGs) can significant consequences. For example, a...
SUMMARY Somatic polyploidization, an adaptation by which cells increase their DNA content to support cell and organ growth, is observed in many mammalian types, including cardiomyocytes. Although polyploidization beneficial contexts, progression a polyploid state often accompanied loss of proliferative capacity. Recent work suggests that heterogeneity cardiomyocyte ploidy highly influenced genetic diversity. However, the developmental course cardiomyocytes reach final has only been...
Cardiomyocytes are polyploid, but how this polyploidy is established during development unclear. In a new paper in Development, Samantha Swift and colleagues reveal variation cardiomyocyte between mouse strains identify candidates that regulate phenotype. We caught up with first author, Swift, corresponding Michaela Patterson (Assistant Professor at the Medical College of Wisconsin, USA), to learn more about their research.
This case study examines Yanchar, Spackman, and Faulconer’s “Learning as Embodied Familiarization” (hereafter LAEF) framework in the of a violinmaking apprenticeship. Its purpose is to critically examine each facet LAEF manifest lived experience both master apprentice. While previous studies investigating this have used various qualitative hermeneutic methodologies, none done so from prolonged, ethnographic perspective. perspective comes an immersive autoethnography which I apprenticed under...
Polyploidization is a normal cellular adaptation for variety of cell types in mammals, including cardiomyocytes (CMs); however, the development polyploidization understudied. Recent work suggests that genetics contribute to diverse displays ploidy adult murine heart. Therefore, we hypothesized developmental progression reach differing end-states may similarly be affected. Here, assessed CM endowment, cycle, and temporally across two inbred mouse strains, A/J C57Bl/6J. Consistent with...
The longstanding belief in the field is mammalian heart incapable of regenerating. However, findings regarding variability regenerative capacity hearts are opening door for such a possibility. Mononuclear diploid cardiomyocytes (MNDCMs) subpopulation CMs believed to be capable mounting response and prevalence MNDCM population variable trait. Thus, if we can understand genetic mechanisms governing variability, it could indicate strategies stimulate an endogenous response. Using genome-wide...
Factors responsible for cardiomyocyte proliferation may serve as a potential therapeutic to stimulate endogenous myocardial regeneration following insult, such ischemic injury. A previously published forward genetics approach assessing the frequency of rare and presumed proliferation-competent subpopulation cardiomyocytes, mononuclear diploid cardiomyocytes (MNDCMs), led us transcription factor RUNX1. It is established that RUNX1 induction in increases after Here, we examine effect on cell...
Adult mammalian cardiomyocytes (CMs) are thought to be post-mitotic and therefore unable regenerate the myocardium after injury. In recent years various studies have shown that adult CM is capable of a small amount proliferation, potentially restricted subset CMs. One such study demonstrated having greater percentages rare mononuclear diploid cardiomyocyte (MNDCM) associated with improved outcomes myocardial infarction (MI). An accompanying genome-wide association analysis identified genetic...
For Model-Driven Engineering (MDE) to become Agile, it is has be usable with and for DevOps as the technical basis of Agility. We describe our experiences in implementing applying BB8 architecture that provides a means reuse Eclipse-based MDE toolkits within an integrating workflow system. use Gitlab system discuss future research fields emerge result implementation.