Background Enhanced recovery after surgery (ERAS) procedures are increasingly recognized for their ability to improve surgical outcomes and shorten hospital stays, particularly in resource-constrained environments like Pakistan. This study underscores the transformative potential of ERAS protocols not only enhancing patient but also optimizing healthcare resource utilization such settings. The research aimed evaluate effectiveness reducing postoperative complications stays among patients...

Background The inhibition of programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) signaling pathway has been shown to be an effective targeted therapy in fighting both solid organ cancers and hematological malignancies. PD-L1 expression also serves as a prognostic marker various cancers. However, the its significance multiple myeloma remains largely unknown. Methods Immunohistochemistry staining was performed bone marrow biopsy samples (total 85 samples) 32 patients...

Limited information is available based on single-center studies trends of incidence and outcomes in gastrointestinal (GI) bleed with shock.We analyzed data from 2002 to 2013 National Inpatient Sample. Using ICD-9 codes we identified 6.4 million hospital discharges GI Sample database. Events were type bleed, in-hospital mortality, hemodynamic status, use blood products.GI shock results higher mortality (20.77% vs. 2.6% without shock). Between 2013, there has been an increase the percentage...

Gabapentin is a federally non-scheduled anticonvulsant used in clinical practice for several neuropsychiatric conditions. Reports of abuse and descriptions desirable effects experienced by users are frequent the literature. The following case reports patient with compulsive gabapentin despite lack previously described effects.

The aim of this study is to describe the characteristics and outcome thyroid storm patients presenting at two tertiary care centres Karachi, i.e. Dow University Health Sciences; Liaquat National Hospital, from

Background: Tocopherols are found to be useful in reducing the harmful effects of noise stress on histomorphology testicles rats exposed stress. Objective: To investigate protective tocopherol chronic Materials and Methods: Study was approved by Ethical Review Committee Army Medical College, Rawalpindi dated 02-09-2022. It a Lab based experimental trial conducted for three months. Ninety male albino weighing between 250-300g were housed NIH animal house. The animals divided randomly into 3...

Children who suffer from long-term illnesses, including asthma, cystic fibrosis, diabetes, or epilepsy, sometimes struggle to manage their ailments, which affects quality of life and how often they use healthcare services. This study aimed explore comprehensive management strategies for children with a focus on enhancing reducing hospital admissions. A prospective cohort research was conducted involving 480 children, divided into four groups: 120 epilepsy. Participants were evaluated at...

Background: Nanomedicine is believed to be an emerging field improve the efficacy of conventional chemotherapy. Nanoparticles (NPs), particularly drugs conjugated nanometals, have garnered attention as distinct drug carriers in terms improved pharmacokinetic and pharmacodynamic properties compared traditional formulations. This study aimed investigate potential silver gold-loaded antibiotic Azithromycin demonstrating tumour-suppressing behaviour. Methods: Cells after being treated with...

Objective: To assess the proportion of women presenting with preterm delivery because preeclampsia or placental insufficiency (PREPI) anti-phospholipid antibodies (APLA). Material and Methods:This was a prospective cohort study conducted at an obstetrics gynecology department.Women, aged 20-40 years, who delivered before 34 weeks were cases while those but did not have acted as controls.Both groups had APLA measured diagnosis 12-weeks postnatally.Anti-phospholipid antibody syndrome (APS)...

Little is known about the role of serum uric acid and its impact on lipid fraction. The associations between hyperuricemia much co-morbidity such as dyslipidemia others are well recognized. This study aims to explore Allopurinol & Febuxostat levels in patients. An interventional clinical was conducted Medical OPD, Civil Hospital Karachi. period six months, from September 2018 March 2019. In this trial, after ERC approval, 70 enrolled patients, 60 registered patients sUA>6.8 mg/dl,...

Background and objective Gabapentinoids are the first-line drugs for neuropathic pain. These substrate of organic cation transporter (OCTN1) renal excretion absorption across intestinal epithelium. exhibit wide interindividual variability in daily dosage therapeutic efficacy which makes titration regimens prolonged optimal efficacy. The present study aimed to investigate possible influence single nucleotide polymorphism (SNP) OCTN1 on safety gabapentinoids pain patients Pakistani population....

Background: Type 2 diabetes mellitus (DM) has a strong genetic component. Individuals of parent with type DM have an increased (40%) risk diabetes. If both parents DM, the approaches to 70%. Thus, this study was designed evaluate cardiovascular parasympathetic functions in offsprings diabetic parents. Aims and Objectives: Study done compare observe degree changes (if any) function tests (cases) non-diabetic (controls) provides timely lifestyle modifications prevent development its...

Objective: This research work deals with the mechanism of action involved in determining therapeutic potential histamine and its blockers gastrointestinal motility. Study Design: Rabbits equal weights were used this study. They brought from animal house BMSI, sacrificed Pharmacology Research laboratory. Ileum strip isolated special recommended methodology, longitudinal circular muscles separated. Individual muscle then exposed separately to desired drugs organ bath reading recorded on...

Continuous obstacles behind the discovery of novel drugs for cancer therapy have necessitated development alternative strategy drug repurposing—the old new therapeutic purposes. With an improved understanding hallmarks cancer, this offers a cost-effective process treatment human neoplastic disease, thereby facilitating rapid clinical translation. In regard, macrolide antibiotics (MAs), which include wide spectrum activities against Gram-positive bacteria, also been proposed as anticancer...

The thrombolytic efficacy of recombinant tissue-type plasminogen activator (tPA) in the presence and absence selective endoperoxide/thromboxane A2 (TXA2) receptor antagonist, sulotroban (BM 13.177, SK&F 95587) was studied a model femoral artery thrombosis anesthetized rabbit. thrombus formed by injection thrombin, CaCl2 whole blood into an isolated segment artery. After 30 min stable thrombotic occlusion artery, tPA infused IV for 90 at doses 5.0, 7.5 10.0 micrograms/kg/min. In other...

Introduction: Recent evidence suggests that packed red blood cells (PRBC's) transfusion in hemodynamically stable gastrointestinal hemorrhage patients with target hemoglobin above 7 have no mortality benefit. Most studies done on Gastrointestinal (GI) exclude shock. We wanted to study the effect of PRBC's GI bleeding especially Methods: conducted a retrospective analysis using 2009-2013 Healthcare Cost and Utilization Project -Nationwide Inpatient Sample (HCUP-NIS). were identified by CCS...

Background: Salmonella typhi, a rod-shaped Gram-negative bacterium that stands responsible for causing typhoid fever, in places with poor sanitation and polluted water. Injudicious antibiotic practices have significantly added to the rise of multidrug-resistant (MDR) extensively drug-resistant (XDR) typhi. This study aimed determine frequency susceptibility pattern typhi blood cultures patients fever. Methods: cross-sectional retrospective was conducted from November 2018 2019 at Tahir...