About
Contact & Profiles
A5020070306
Research Areas
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
Capital Medical University
2022-2025
Beijing YouAn Hospital
2025
10.1038/s41556-024-01549-x
article
EN
Nature Cell Biology
2025-01-02
Fatty acid uptake is essential for cell physiological function, but detailed mechanisms remain unclear. Here, we generated an acetyl-CoA carboxylases (ACC1/2) double-knockout line, which lacked fatty biosynthesis and survived on serum acids was used to screen inhibitors. We identified a Food Drug Administration–approved tricyclic antidepressant, nortriptyline, that potently blocked both in vitro vivo. also characterized underlying whereby nortriptyline provoked lysosomes release protons...
10.1084/jem.20221316
article
EN
cc-by-nc-sa
The Journal of Experimental Medicine
2022-11-29
10.15252/embj.2022111268
article
EN
The EMBO Journal
2022-11-21
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