A5061016536- Immune cells in cancer
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Cholesterol and Lipid Metabolism
- Mycobacterium research and diagnosis
- Traditional and Medicinal Uses of Annonaceae
- Drug Transport and Resistance Mechanisms
- Food Chemistry and Fat Analysis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Effects and risks of endocrine disrupting chemicals
- Medicinal Plants and Neuroprotection
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Sphingolipid Metabolism and Signaling
- Salmonella and Campylobacter epidemiology
- Phytochemistry and biological activities of Ficus species
- Cocoa and Sweet Potato Agronomy
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Sperm and Testicular Function
- interferon and immune responses
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
World University of Bangladesh
2023-2025
Manarat International University
2023
Jahangirnagar University
2020
Chung-Ang University
2018-2020
Hanyang University
2016-2018
Microglia are resident myeloid cells in the CNS that activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been primary vitro models used to study neuroinflammation for more than a decade because they reduce requirement of continuously maintaining preparations animal experimentation models. However, doubt has recently raised regarding value as model system. We triplicate RNA sequencing (RNA-seq) investigate molecular signature using two...
Macrophages are the prime innate immune cells of inflammatory response, and combination multiple signaling inputs derived from recognition host factors (e.g., interferon-g/IFN-γ) invading pathogen products TLR agonists) required to maintain essential macrophage function. The profound effects on biological outcomes inflammation associated with IFN-γ pretreatment ("priming") TLR4 ligand bacterial LPS-induced activation (M1 or classical activation) have long been recognized, but underlying...
In the past few years, bisphenol A, (BPA) an endocrine-disrupting chemical, has received increasing attention because of its detrimental health effects. There is ample evidence to support that BPA interferes with reproductive humans and animals. spermatozoa, BPA-induced adverse effects are mostly caused by increased oxidative stress. Using in vitro experimental model, we examined whether antioxidants (glutathione, vitamin C, E) have defensive against stress spermatozoa. The results showed...
Poor sensitivity of pathogenic bacteria to is a serious health issue worldwide specially in the developing and underdeveloped countries making greater concern scientists. This study followed CLSI (Clinical Laboratory Standards Institute) guidelines 30, Kirby-Bauer disc diffusion method test sensitivity. We analyzed antibiotic pattern Escherichia coli Salmonella typhi isolated from clinical samples, collected two hospitals Dhaka, Bangladesh. The twelve different single antibiotics (cefepime,...
Litsea glutinosa (LG) leaves have been traditionally used in ethnomedicine for the treatment of various ailments, including pain, fever, and microbial infections. This study aims to scientifically evaluate therapeutic potential cold methanol extracts LG leaves, specifically focusing on their analgesic, antipyretic, antibacterial activities. In addition, research includes preliminary phytochemical screening identify key bioactive compounds an acute toxicity test assess safety profile extract....
Persistent microglial activation is associated with the production and secretion of various pro-inflammatory genes, cytokines chemokines, which may initiate or amplify neurodegenerative diseases. A novel synthetic histone 3 lysine 27 (H3K27) demethylase JMJD3 inhibitor, GSK-J4, was proven to exert immunosuppressive activities in macrophages. However, a genome-wide search for GSK-J4 molecular targets has not been undertaken microglia. To study immuno-modulatory effects at transcriptomic...
Studies have demonstrated the association between LXR activity dysregulation with many diseases, including atherosclerosis, diabetes and cancer. In recent years, several agonists surfaced, but none been approved for human use due to adverse effects or unforeseen reasons. this study, we first analysed mRNA protein expression of LXRs across tissues, network pathway analysis, reinterpreted their physiological function disease by utilizing multiple biological data repositories, RNA-seq atlas,...
Abstract Litsea monopetala (LM) leaves are used in traditional medicine systems the South Asian region for treating ailments such as digestive issues, respiratory problems, and skin disorders. In this study, we first investigated possible antioxidant, thrombolytic characteristics, analgesic, antidiarrheal activity of methanolic crude extract LM leaves. To assess thrombolytic, DPPH free radical scavenging, clot lysis, acetic acid, castor oil-induced animal model, respectively. Before applying...
Background Ficus nervosa (FN) leaves have been traditionally used in ethnomedicine for the treatment of various ailments, this study aimed to investigate cold methanol extract FN its antioxidant, analgesic, antidiarrheal, and thrombolytic properties, along with preliminary phytochemical screening identify key bioactive compounds acute toxicity test assess safety profile extract. Methods In study, we conducted an initial investigation major groups present nervosa. Using conventional methods...
Abstract Background Studies have shown that LXR activity is linked to the development of many diseases, including metabolic diseases. Several agonists been discovered, but none entered human use due undesirable side effects. Method In this study, we used multiple biological data repositories (e.g., RNA-seq, protein atlas, DisGeNET, WebGestalt, and more) examine mRNA expression LXRs across tissues performed network pathway analysis redefine their physiological function disease association. By...