A5077597143- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Carbohydrate Chemistry and Synthesis
- Bacterial biofilms and quorum sensing
- Biochemical and Molecular Research
- Chemical Synthesis and Analysis
- Plant Disease Resistance and Genetics
- Fluorine in Organic Chemistry
- Plant-Microbe Interactions and Immunity
- Chemical Reactions and Isotopes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Bacteriophages and microbial interactions
- Catalytic Cross-Coupling Reactions
- Enzyme Structure and Function
- Plant biochemistry and biosynthesis
- Sulfur-Based Synthesis Techniques
- Steroid Chemistry and Biochemistry
- Cold Fusion and Nuclear Reactions
- Vitamin K Research Studies
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Cancer Research and Treatments
- Insect and Pesticide Research
- Amino Acid Enzymes and Metabolism
- Microbial Metabolism and Applications
University of Manchester
2016-2021
University College Dublin
2013-2014
University of East Anglia
2008-2012
University of Birmingham
2012
Norwich Research Park
2012
University of Warwick
2010
The University of Sydney
1951
Biofilm, friend not foe: Single species biofilms can be engineered to form robust biocatalysts with greater catalytic activity and significantly improved longevity than purified immobilised enzymes. We report the engineering, structural analysis biocatalytic capability of a biofilm that mediate conversion serine haloindoles halotryptophans (see scheme). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but copy-edited or...
Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity novel mode of action there has been considerable interest developing thaxtomins as herbicides for crop protection. To address the need more stable derivatives, we have developed a new approach structural diversification thaxtomins. Genes encoding thaxtomin NRPS from S. scabies, along with genes...
A convenient and high yielding procedure for the Suzuki–Miyaura cross-coupling of unprotected bromo- chlorotryptophans in water provides fluorescent aryltryptophans.
The robust nature of biofilms makes them medicinally difficult to treat, however this same property renders an attractive method for protecting and immobilising enzymes biotransformation. Although consisting a consortium different microbial species have been routinely used in water purification many decades, there are few reported examples single being harnessed industrial applications. potential using tailored order catalyse biotransformation choice is attractive; we reflect upon recent...
β-Methyltryptophans (β-mTrp) are precursors in the biosynthesis of bioactive natural products and used synthesis peptidomimetic-based therapeutics. Currently β-mTrp is produced by inefficient multistep synthetic methods. Here we demonstrate how an engineered variant tryptophan synthase from Salmonella (StTrpS) can catalyse efficient condensation l-threonine various indoles to generate derivatives a single step. Although l-serine substrate for TrpS, targeted mutagenesis StTrpS active site...
Abstract Thaxtomins are diketopiperazine phytotoxins produced by Streptomyces scabies and other actinobacterial plant pathogens that inhibit cellulose biosynthesis in plants. Due to their potent bioactivity novel mode of action there has been considerable interest developing thaxtomins as herbicides for crop protection. To address the need more stable derivatives, we have developed a new approach structural diversification thaxtomins. Genes encoding thaxtomin NRPS from S. , along with genes...
A key problem in the engineering of pathways for production pharmaceutical compounds is limited diversity biosynthetic enzymes, which restricts attainability suitable traits such as less harmful byproducts, enhanced expression features, or different cofactor requirements. promising synthetic biology approach to redesign pathway by replacing native enzymes heterologous proteins from unrelated pathways. In this study, we applied method effectively re-engineer biosynthesis hydroxyphenylglycine...
Electrolysis is used to produce the gas in a small, easily constructed apparatus. Purification carried out by diffusion through palladium tube. The plant uses about 10 g of electrolyte and may be left unattended during operation.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Abstract Review: 41 refs.
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”