A5064005834- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Advanced Semiconductor Detectors and Materials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Surface Polishing Techniques
- High-pressure geophysics and materials
- Semiconductor Quantum Structures and Devices
- Radiation Detection and Scintillator Technologies
- GaN-based semiconductor devices and materials
- Advanced Materials Characterization Techniques
- Semiconductor materials and devices
- Chromatin Remodeling and Cancer
- Force Microscopy Techniques and Applications
- Pancreatic and Hepatic Oncology Research
- Copper Interconnects and Reliability
- ZnO doping and properties
- Electrodeposition and Electroless Coatings
- Ga2O3 and related materials
- Chalcogenide Semiconductor Thin Films
- Advancements in Photolithography Techniques
- 3D IC and TSV technologies
- Additive Manufacturing Materials and Processes
- Pancreatitis Pathology and Treatment
- Nanomaterials and Printing Technologies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Roswell Park Comprehensive Cancer Center
2024
University of Rochester Medical Center
2018-2024
Institut thématique Génétique, génomique et bioinformatique
2018
III-N Technology (United States)
2016
University of Rochester
2016
Columbia-Greene Community College
2011
Tweed Shire Council
2008
Acadia Harvest (United States)
2007
Constellation Technology (United States)
2004-2005
University of Florida
1992-2002
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver cancer epidemiologically linked with injury, which has poorly understood incipient stages and lacks early diagnostics effective therapies. While iCCA conventionally thought to arise from the biliary tract, studies have suggested that both hepatocytes cells (cholangiocytes) may give rise iCCA. Consistent plasticity of these cell lineages, carcinomas exhibit phenotypic range hepatocellular carcinoma (HCC) iCCA, intermediates along this...
Objective Here, we evaluate the contribution of AT-rich interaction domain-containing protein 1A ( ARID1A ), most frequently mutated member SWItch/sucrose non-fermentable (SWI/SNF) complex, in pancreatic homeostasis and ductal adenocarcinoma (PDAC) pathogenesis using mouse models. Design Mice with a targeted deletion Arid1a pancreas by itself context two common genetic alterations PDAC, Kras p53 , were followed longitudinally. Pancreases examined analysed for proliferation, response to...
We have prepared oxides having various yttrium to aluminum ratios and exposed them fluorine‐based plasma. The etch rate of the oxide decreased abruptly with addition then slowly further addition. had a more fluorinated surface than oxide, indicating that was not determined by fluorination, contrary etching Si‐based materials. From X‐ray photoelectron spectroscopy (XPS) analysis multication YAlO 3 single crystal, similar tendency observed, showing higher ratio Y–F Y–O bonding Al–F Al–O. Angle...
Activating KRAS mutations and functional loss of members the SWI/SNF complex, including ARID1A, are found together in primary liver tumor cholangiocarcinoma (CC). How these cooperate to promote CC has not been established. Using murine models hepatocyte biliary-specific lineage tracing, we show that Kras Arid1a drive formation precursors from biliary compartment, which accelerated by inflammation. cultured cells, find causes cellular proliferation, escape cell-cycle control, senescence,...
ABSTRACT Cholangiocarcinoma (CCA) is a deadly and heterogeneous type of cancer characterized by spectrum epidemiologic associations as well genetic epigenetic alterations. We seek to understand how these features inter-relate in the earliest phase development through course disease progression. For this, we studied murine models liver injury integrating most commonly occurring gene mutations CCA – including Kras, Tp53, Arid1a Smad4 hepatobiliary derived primary cell lines based on mutations....
Phospholipase C-ε (PLC-ε) is a unique PLC isoform that can be regulated by multiple signaling inputs from both Ras family GTPases and heterotrimeric G proteins has primary sites of expression in the heart lung. Whereas role PLC-ε cardiac function pathology been documented, its relevance acute lung injury (ALI) unclear. We used −/− mice to address regulating vascular inflammation an aerosolized bacterial LPS inhalation mouse model ALI. showed marked decrease LPS-induced proinflammatory...
The psychiatric needs of those with cancer and other advanced illnesses are becoming increasingly recognized. Ketamine is emerging as a promising treatment option for depressive disorders in palliative care. In the care setting, its study has been hindered by lack consistent administration routes dosing. Intranasal (IN) esketamine (Spravato
The effects of several chemical treatments on ZnSe surface composition and morphology have been analyzed with scanning electron microscopy Auger spectroscopy. Polycrystalline bulk thin film heteroepitaxed onto GaAs were used. Large variations in the etching rate conditions, such as roughness, contamination, oxides, stoichiometry, observed different etchants. Contamination by carbon oxygen was present all treated surfaces. Surface oxides could be thinned dipping HF or HF/NH4Cl, which did not...
Abstract Measurements of electromigration in single crystals cadmium have been made as a function orientation. The resulting values for the effective charge numbers are Z =1.5 4 ± 0.15 and ⊥ =3.2 0 ±0.3. results also expressed terms charges separate atomic jumps, (1) to vacancy same basal plane (2) an adjoining plane. While parallelism these findings with those zinc is apparent, there one significant difference. In creation (and annihilation) tends alter c-axis dimension preferentially.
Ohmic contacts to p-GaN were obtained after annealing Ni/Au and Ni/Au/Ni in flowing O2. Both Ni-capped p-GaN/Ni/Au uncapped shown result specific contact resistance of ∼10−4 Ω cm2. In both cases, transparent NiO thin, porous Au films formed. exhibited optical transmittance at λ=450 nm >85%. Addition the Ni cap layer was increase thermal stability thin ohmic 450 93%, while maintaining a low resistance. The ability capping produce these improvements discussed based on total energy model...
Focal plane arrays (FPAs) made on InSb wafers are the key cost-driving component in IR imaging systems. The electronic and crystallographic properties of wafer directly determine device performance. "facet effect" describes non-uniform crystals resulting from anisotropic dopant segregation during bulk growth. When coefficient impurities changes notably across melt/solid interface a growing crystal result is these crystals. effect more pronounced grown (111) axis compared with other...
We present a new method to produce low-cost, high quality gallium antimonide (GaSb) substrates for IR imaging applications. These methods apply high-volume wafer manufacturing standards from the silicon industry increase performance and value of our wafers. Encapsulant-free GaSb single crystals were grown using modified Czochralski method, yielding more than seventy 150mm wafers per crystal or several hundred 75mm 100mm crystal. processed into epi-ready on which superlattice structures...
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MicroRaman spectroscopy has been used to measure stress in diamond with improved precision. Stress was induced by rf sputter deposited tungsten films of 1- and 9-μm thickness. Preliminary data showed a systematic error the Raman peak position about 0.05 cm−1/scan, which led inaccurate imprecise measurement. A new technique, using reference 5520-Å krypton line only 10.5 cm−1 from line, results an order magnitude increase measurement Using this calibration, could be measured precision ±0.03...
We investigated bulk-grown HgI<sub>2</sub> crystals to better understand the nature of crystallographic defects and strain/stress in different growth regions crystal their affect on performance HgI<sub>2</sub>-based radiation detectors. Double-axis triple-axis high-resolution x-ray diffraction were used characterize mosaic structure strain HgI<sub>2</sub>. Rocking curves revealed significant spreading <110> exhibiting X-defects versus X-defect-free <100> regions. Both exhibited little...
A review of bubble energetics is presented to provide background into gas saturation and formation in semiconductor resists. Nitrogen was used as a drive push liquid out several package materials versus mechanical pump. The incorporation dissolved measured barrier liner found be superior bottle with no liner. We have demonstrated that pressure dispense an appropriate provides means deliver lithographic chemicals resist without the use
Models of intrahepatic cholangiocarcinoma: novel tools and therapeutic applications Margaret A Hill,1,2,* William B Alexander,1,2,* Aram F Hezel1,2 1Department Biomedical Genetics, 2Department Medicine, Hematology/Oncology, Wilmot Cancer Institute, University Rochester Medical Center, Rochester, NY, USA *These authors contributed equally to this work Abstract: Intrahepatic cholangiocarcinoma (iCCA) is the second most common hepatic malignancy, a number recent studies have identified an...
Abstract not Available.