A5072295133- Advanced Electron Microscopy Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Photosynthetic Processes and Mechanisms
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Molecular Communication and Nanonetworks
- Advanced biosensing and bioanalysis techniques
Janelia Research Campus
2015-2021
Howard Hughes Medical Institute
2015-2021
The cellular distribution of mitochondria in response to stress and local energy needs is governed by the relative activities kinesin dynein. mechanism for switching between these two opposite polarity microtubule motors remains unknown. Here, we coupled a novel synthetic cargo transport assay with AlphaFold2-guided mutagenesis identify regulatory helix mitochondrial adaptor protein (TRAK) that mediates kinesin- dynein-driven transport. Differences sequence explain why near-identical TRAK...
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