Applications of machine learning in chemistry are many and varied, from prediction structure–property relationships, to modeling potential energy surfaces for large scale atomistic simulations. We describe a generalized approach the application classification spectra which can be used as basis wide variety undergraduate projects. While our examples use FTIR mass spectra, could equally well with UV–visible, Raman, NMR, or indeed any other type spectra. summarize number different unsupervised...

Since the sudden emergence of COVID-19 global pandemic, all educational institutions have looked to move resources and delivery online. Some had already embraced delivering instruction in this way; however, broader adaptation teaching style is new many educators. While theoretical concepts more easily transferred a blended learning environment, practical chemistry poses significant challenges, yet it crucial chemist's identity. Here we describe establishment new, international, network...

Abstract Teaching practical laboratory skills is a key component of preparing undergraduate students for future careers in chemistry and elsewhere. In this paper, we present our new strategy to teach students. We report Skills Inventory, list the suggested graduate chemist should possess; was compiled by chemists across UK. course begin decoupling skill from theoretical background, compelling first master basic processes needed carry out specific technique. what have termed ‘spiral...

Teaching practical chemistry skills remotely is not a task that would have been high on the agenda only few months ago. However, in light of COVID-19 pandemic, students around world are having to work from home, and education community has forced adapt new circumstances. In response, we discuss use simulations place laboratory work, with emphasis development students' experimental design skills. The simulation Michaelis–Menten enzyme kinetics given as an example exercise, which other...

Mass spectrometry (MS) is introduced to high school students in the UK many pre-university course syllabi. As such, we have identified use of MS as a key technique that should be taught practically undergraduates from outset their studies. This mini-review describes how introduce and develop students' throughout our three-year undergraduate spiral curriculum practical programme, using atmospheric pressure chemical ionization (APCI-MS).

UDP-GalNAc pyrophosphorylase (UDP-GalNAcPP; AGX1) catalyzes the synthesis of from UTP and GalNAc-1-P. The 475-amino acid protein (57 kDa protein) also synthesizes UDP-GlcNAc at about 25% rate UDP-GalNAc. cDNA for this enzyme, termed AGX1, was cloned in Escherichia coli, expressed as an active enzyme that cross-reacted with antiserum against original pig liver UDP-HexNAcPP. In present study, we incubated recombinant AGX1 N3-UDP-[32P]GlcNAc N3-UDP-[32P]GalNAc probes to label nucleotide-binding...

This paper describes the application of an accessible, benchtop mass spectrometer using Atmospheric Solids Analysis Probe (ASAP) for easy sample introduction, coupled with Pressure Chemical Ionization (APCI) as a soft ionization technique, to inquiry-based identification metal composition alloys, including coins. Students experience preparation acetylacetonates via traditional salt metathesis and electrochemical methods. They are then encouraged immediately apply these newly acquired skills...

The reduction of nitroarenes to anilines is a key transformation with real-life context, central the preparation many important fine chemicals. importance this has led its inclusion in not only university organic chemistry courses but also preuniversity, especially Europe. A variety reagent combinations have been developed achieve reduction, each own merits; we report herein comparison most common methods and what how taught students. Reviewing preuniversity syllabi textbooks, reveal...

Machine learning is a set of tools that are increasingly used in the field chemistry. The introduction potential uses machine to undergraduate chemistry students should help increase their comprehension and interest processes can support them transition into graduate research industrial environments use such tools. Herein we present an exercise aimed at introducing alongside improving students' general Python coding abilities. aims identify regioisomerism disubstituted benzene systems solely...

By adapting a well-established expository style practical on the topic of chemoselectivity, we present our successful approach to introducing elements guided inquiry and decision-making novice undergraduate chemists. Using nitroacetophenone as polyfunctional substrate, students investigate effect using two different classes reducing agents (reducing metal vs hydride donor). changing emphasis be investigatory in nature, actively deduce outcomes reactions, choosing suitable spectroscopic...

Data-handling, processing, and analysis skills are an integral part of a chemist's skill set and, more generally, highly sought by employers. We report self-directed workshop to develop advance these key using the popular spreadsheet program Microsoft Excel. Making use its accessible user interface, various contextualized problems relevant chemistry introduced, linking theory practical applications providing insight understanding processes that operate behind-the-scenes in many specialized...

The COVID-19 pandemic has resulted in a need for social distancing measures public spaces and will have an important impact on university level teaching going forward. Remote methods to complete laboratory related activities are potential means of students achieving practical credit while still isolating or distancing. We outline the implementation two novel remote exercises, based coding Mathematica, used provide ongoing help students. These exercises as case study identify problems with...

A practical focusing on the synthesis, isolation, and hydrolysis of ammonia borane (AB), H3N·BH3, was developed for first-year undergraduate students. By requiring students to propose their own experimental setup measure amount gas produced upon hydrolysis, design skills were introduced during practical. As a result COVID-19 pandemic, remote face-to-face versions created enable inclusivity in which key feature. Students identified reported an appreciable increase skills. The multifaceted...

Earth's field nuclear magnetic resonance (EFNMR) spectroscopy offers students a unique opportunity to consolidate their understanding of NMR spectroscopic theory through hands-on practice with simple spectrometer. A comprehensive, 6 h experiment is presented for the introduction low-field techniques, covering spectroscopy, relaxivity, and imaging experiments in field. This multifaceted practical session explores concepts free induction decay, pulse sequences, homogeneity, relaxation times,...

The COVID-19 (SARS-CoV-2) pandemic brought in-person teaching to an abrupt halt in March 2020 posing the problem of how continue deliver undergraduate courses remotely. This paper presents a detailed case study three international online Higher Education (HE) networks which formed address critical need support laboratory UK and Australia. employed sequential mixed methods design using survey followed by structured discussions with network leads. findings show these provided space for...

Rationale: Mass spectrometry (MS) is introduced to high school students in the UK many pre-university course syllabi. As such, we have identified use of MS as a key technique that should be taught practically undergraduates from outset their studies. This mini‑review describes how introduce and develop students’ throughout our three‑year undergraduate spiral curriculum practical program, using atmospheric pressure chemical ionisation (APCI/MS). Methods: We used an Advion Expression...

ADP-ribosylation factor 6 (ARF6) is a member of family ~20-kDa guanine nucleotide-binding proteins that has been implicated to function in membrane ruffling and cell motility, endocytosis, exocytosis, recycling. Sequence analysis the human ARF6 gene indicates it spans 4004 bp, contains single 98-bp intron within 5'-untranslated region, localized chromosome 14q21. Similar class II ARF transcripts, translation mRNA initiates second exon. Primer extension assays indicate major transcription...

Horner-Wadsworth-Emmons reaction of stannylvinylphosphonates with aldehydes and mild thermal cyclisation provides disubstituted arylstannanes. Subsequent Stille coupling leads to regiospecific synthesis m- p-terphenyls.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”

Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis , has afflicted mankind for millennia. Currently, diagnosis of TB from archaeological specimens relies on identification bone changes. This method is problematic, since changes seen in are not exclusive to disease. Here, we examine state-of-the-art ancient using biomarker approach. The development biomarkers detection will provide a reliable means and archaeology with useful tool investigation populations.

Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis , has afflicted mankind for millennia. Currently, diagnosis of TB from archaeological specimens relies on identification bone changes. This method is problematic, since changes seen in are not exclusive to disease. Here, we examine state-of-the-art ancient using biomarker approach. The development biomarkers detection will provide a reliable means and archaeology with useful tool investigation populations.

Innovations as well modifications of more traditional approaches to the teaching undergraduate and graduate paleontology at Macquarie University have been developed help teach large classes internal students (traditional full-time day students, part-time evening students) external (students who work largely home, attending university only for concentrated blocks instruction practical on weekends or during vacations). These are aimed especially our many whom fundamentally biologists rather...