A5035754554- PARP inhibition in cancer therapy
- Neurological and metabolic disorders
- Prostate Cancer Treatment and Research
- Multiple Myeloma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tuberous Sclerosis Complex Research
- Alcoholism and Thiamine Deficiency
- Radiopharmaceutical Chemistry and Applications
- Brain Metastases and Treatment
- Toxin Mechanisms and Immunotoxins
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
IASO General Hospital
2023-2025
Metaxa Hospital
2023-2024
Phantosmia belongs to the group of olfactory dysfunctions. It is more commonly described in psychiatric conditions and some cases viral infections, but it has been also rarely cancer patients who develop primary or metastatic central nervous system tumors; early identification this symptom population crucial, as could lead timely diagnosis treatment through a multidisciplinary approach. With current report we present case 60-year-old lady with breast without known preexisting brain...
Introduction: Wernicke Encephalopathy (W.E.) is an acute neurological disorder induced by thiamine deficiency. Alcohol abuse considered to be the leading cause of disease; however, numerous other conditions, such as malnutrition or cancer, have been identified potential risk factors. Case Presentation: Clinical manifestations include a typical triad mental status alteration, nystagmus, and ataxia are attributed damage in brain regions high demand. The diagnosis mainly clinical further...
Background: Colorectal carcinoma (CRC) is one of the most common malignancies in Western world, and metastatic disease associated with a dismal prognosis. Poly-ADp-ribose polymerase (PARP) inhibitors gain increasing attention field medical oncology, as they lead to synthetic lethality preexisting alterations DNA damage repair (DDR) pathway. As those are frequently seen CRC, targeted approach through PARP expected benefit these patients, both alone combination other agents like chemotherapy,...
Metastatic castrate-resistant prostate cancer (mCRPC) is a challenging disease, especially in heavily pretreated patients. Androgen pathway inhibitors have contributed to notable improvement the overall survival and quality of life patients with mCRPC during last decade. Still, considerable percentage are unable draw benefits from this drug category deprived treatment that offers limited toxicity preserves good life. The mechanisms leading pre-existing or acquired resistance, as well...
Background: Tuberous sclerosis complex (TSC) is a rare genetic disease that affects multiple organs and the quality of life. Mutations in TSC1 TSC2 genes are causing dysregulations mammalian target rapamycin (mTOR) pathway, inducing mostly benign but also malignant tumors, including renal cell carcinoma (RCC). The diagnosis TSC, based on established clinical criteria, essential for optimal surveillance management patients. Case Presentation: With current report, we present case two sisters...