The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored relationship between microbial community and GC prognosis therapy efficacy. Several cancer-associated characteristics were identified, including increased α-diversity, differential β-diversity, decreased

Sorafenib, an oral multikinase inhibitor of Raf, VEGF and PDGF receptor signaling is approved for advanced hepatocellular carcinoma (HCC). One strategy to improve HCC therapy combine agents that target key pathways. Aberrant mesenchymal-epithelial transition factor (c-Met) activation associated with a variety human malignancies therefore represents therapy. In this study, we investigated novel c-Met inhibitor, DE605, together sorafenib in cells vitro vivo. DE605 synergistically induced...

Breast cancer (BC) is the most common malignant tumors and leading cause of deaths among women. The early diagnosis treatment BC are effective measures that can increase survival rates reduce mortality. Carbohydrate antigens 15-3 (CA15-3) carcinoma embryonic (CEA) have been regarded as two valuable tumor markers BC. combined detection CA15-3 CEA could improve sensitivity accuracy for BC.The multi-channel double-gate silicon nanowire field effect transistor (SiNW-FET) biosensors were...

Background Minimally invasive esophagectomy was first introduced as a new technique for esophageal cancer treatment 20 years ago. Performing this procedure in the lateral‐prone position is most appropriate method. Since May 2013, our center has performed 124 operations using procedure. Herein, we share experience. Methods We retrospectively reviewed consecutive patients who had received minimally from 2013 to June 2017. The procedure, operative variables, postoperative complications, and...

Alpha-fetoprotein (AFP) is a tumor-associated fetal protein that can be expressed in large amounts adult tumor cells, serving as useful clinical tumor-marker. Silicon nanowire (SiNW) biosensors have emerged powerful tool detecting biomarkers, due to their ultrahigh sensitivity, real-time response and label-free detection. We fabricated SiNW-based field-effect transistor (FET) according "top-down" methodology. First, anti-AFP antibodies were immobilized onto the surface of SiNW-FET. A...

Cervical cancer is the second most common female malignancy worldwide, and prognosis of patients with locally advanced stage poor, a high risk recurrent. This study aimed to explore effect factors that influence overall survival (OS), progression-free (PFS), quality life in III cervical cancer.A two-way follow-up method was utilized collect information from cancer. Survival analyses were performed by Kaplan-Meier Cox regression model. Multiple linear used analyze related life.Four hundred...

The patient, a 34-year-old woman, was admitted due to “a mediastinal mass found during health check-up 3 months ago”. She underwent in local hospital ago, which CT displayed mass. No specific treatment provided. One week she received second CT, showed that the did not change obviously. then visited our for surgical treatment. had no previous history of relevant conditions.

Cervical cancer is the second most common female malignancy worldwide. The main method to evaluate effect of concurrent chemoradiotherapy (CCRT) in locally advanced stage imaging which cannot meet clinical needs. This study aimed explore potential cervical biomarkers via plasma metabolomics and effectiveness CCRT disease progression.Twenty-four primary thirty recurrent patients were enrolled between November 2016 2017. Plasma samples obtained by centrifugation whole blood collected from at...

The current research aimed to demonstrate the independent association between preoperative severe asymptomatic carotid artery stenosis (ACAS) and multi-organ dysfunction after off-pump coronary bypass grafting (OPCAB), which may further indicate relationship ACAS adverse 30-day postoperative outcomes of patients undergoing OPCAB.

RPF2 plays a crucial role in promoting epithelial-mesenchymal transition (EMT) and regulating metastasis colorectal cancer (CRC). By analyzing data from the TCGA GEO databases, we observed significantly elevated expression CRC, which correlated with EMT markers. Further investigations using stable overexpression knockdown cell lines demonstrated that facilitates activation through AKT/GSK-3β signaling pathway. Notably, CARM1 was identified as key downstream effector of RPF2. Selective...

As an emerging diabetes diagnostic indicator and a dynamic change index, HbA1c can not only reflect the average blood glucose level over period of time but also well predict incidence related microvascular complications. It is important to develop detection method that dynamically characterize HbA1c. Silicon nanowire (SiNW) devices were mass-produced using top-down sputtering technology, microdialyzer was installed in SiNW field effect tube biosensor system. Finally, system used detect...

Medical history. The patient, a 28-year-old woman, was found to be with the drooping left eyelid half year ago, but did not receive special treatment. A few months later, symptom gradually worsened and then patient visited local hospital. Chest CT showed thymic hyperplasia in anterior mediastinum. diagnosis “thymic accompanied myasthenia gravis”. She orally administered pyridostigmine bromide 60 mg tid, symptoms were controlled. Then, she our hospital for further management. patient’s...

The patient was admitted due to “a mediastinal mass found during health check-up four months ago”. Four ago, she in a local hospital gas poisoning, which CT showed right posterior mass. Later then discharged after the poisoning resolved. She visited our for surgical treatment. has previous history of hypertension 20 years and diabetes 7 years. underwent resection uterine myoma 10 ago.

The operation is performed under general anesthesia with double-lumen endotracheal intubation. patient placed in the lateral position on unaffected side. Singlelung ventilation holds a pillow both upper limbs flexed and jackknife position.

Paranasal concavity is esthetically displeasing and interferes with the overall outline of face. augmentation alloplastic implants a minimally invasive procedure significant esthetic effects for paranasal concavity. When fixing implants, screws should be placed on nasofrontal column, but are occasionally mispositioned anterior wall maxillary sinus. Here, authors introduce case in which self-tapping screw accidentally penetrated through implant, broke medial walls sinus, entered nasal cavity....