A5048697365- Plant biochemistry and biosynthesis
- Cyclopropane Reaction Mechanisms
- Ionic liquids properties and applications
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Multicomponent Synthesis of Heterocycles
- Congenital heart defects research
- Antimicrobial Peptides and Activities
- Polysaccharides and Plant Cell Walls
- Congenital Heart Disease Studies
- Antifungal resistance and susceptibility
- Synthesis and Biological Evaluation
- Plant Gene Expression Analysis
- Fungal Infections and Studies
- Synthesis of Indole Derivatives
- Cardiac Structural Anomalies and Repair
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
Middle Tennessee State University
2013-2016
Children's Healthcare of Atlanta
2016
National Center on Birth Defects and Developmental Disabilities
2016
Centers for Disease Control and Prevention
2016
Studies show there is an increasing rate of fungal infections, especially in immunocompromised patients and treatments for genera, such as Aspergillus, Candida, Cryptococcus, carry significant cytotoxicity with prevalence antifungal resistance. We have previously reported a high-throughput assay identifying peptoids antimicrobial properties from combinatorial libraries. Here we report the application this peptoid against Cryptococcus neoformans. Termed AEC5, has comparable potency to...
Components previously reported from Cyclocarya paliurus include the oleananes cyclocaric acids A and B, with acid possessing an oxetane ring. Isolation of plant extract comparison to literature report show that compound originally as is, in fact, hederagenin. This was confirmed by independent synthesis indicates may not actually be a natural product.
Two triterpenes were isolated using bioassay guided fractionation from the ethanol extract of Cyclocarya paliurus. Comparison to NMR spectra a prior isolation reported in literature showed these two compounds be previously Cyclocaric Acids A and B. However, after additional research into oleanolic class compounds, an independent synthesis Acid hederagenin was completed. The conclusion is that structures incorrect. Updated structure spectral data will presented.