A5013930665- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Alzheimer's disease research and treatments
- Cardiovascular Effects of Exercise
- Thermoregulation and physiological responses
- Click Chemistry and Applications
- Hormonal Regulation and Hypertension
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Heart Rate Variability and Autonomic Control
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
Universidade Federal de Ouro Preto
2015-2022
Background: Left ventricular hypertrophy (LVH) is an endpoint of hypertensive cardiac alterations. Renin-angiotensin-aldosterone system (RAAS) blockers are among the most effective on LVH regression. Physical exercise combined to antihypertensive drug contributes arterial pressure (AP) control and prevention. We evaluated effects physical captopril or losartan during eight weeks for spontaneously rats (SHR) some parameters.Methods: SHR (n=5-6 per group) were sedentary trained 5 days a week...
Abstract For the first time, compounds developed from 1,2,3‐triazole scaffold were evaluated as novel drugs to treat triple‐negative breast cancer (TNBC). Four organic salts idealized nonclassical bioisosteres of miltefosine, which is used in topical treatment for skin metastasizing carcinoma. Among them, derivative dhmtAc displayed better solubility and higher cytotoxicity against human adenocarcinoma cell line mouse 4T1 lines, are representatives TNBC. In vitro assays revealed that...