A5056853890- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Ocular Surface and Contact Lens
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Photocatalysis Techniques
- Rheology and Fluid Dynamics Studies
- Advanced biosensing and bioanalysis techniques
- 3D Printing in Biomedical Research
- Quantum Dots Synthesis And Properties
- Polymer crystallization and properties
- Biosensors and Analytical Detection
- Gold and Silver Nanoparticles Synthesis and Applications
- Electrodeposition and Electroless Coatings
- Additive Manufacturing and 3D Printing Technologies
- Advancements in Battery Materials
- Perovskite Materials and Applications
- Advanced Sensor and Energy Harvesting Materials
- Advanced Battery Materials and Technologies
- Polysaccharides Composition and Applications
- Semiconductor materials and devices
- Diamond and Carbon-based Materials Research
- Nanofabrication and Lithography Techniques
- Cellular Mechanics and Interactions
University of North Carolina at Chapel Hill
2025
Ulsan National Institute of Science and Technology
2015-2024
Inha University
2007-2024
Myongji University
2024
Hanyang University
1998-2023
Seoul National University
2006-2023
Samsung (South Korea)
2023
The University of Texas at Austin
2023
Yonsei University
2020
Sungkyunkwan University
2020
Current protocols to encapsulate cells within physical hydrogels require substantial changes in environmental conditions (pH, temperature, or ionic strength) initiate gelation. These can be detrimental and are often difficult reproduce, therefore complicating their use clinical settings. We report the development of a two-component, molecular-recognition gelation strategy that enables cell encapsulation without triggers. Instead, two components, which contain multiple repeats WW proline-rich...
Potassium is an important cation in biology, and quantitative detection of the extracellular potassium level important. However, selective physiological a challenging task due to presence sodium much higher concentration. In this contribution, we describe development practical polydiacetylene (PDA) liposome-based microarrays selectively detect even sodium. We utilize fact that G-rich ssDNA can fold into G-quadruplex via intramolecular hydrogen bonding by wrapping around ion exclusively....
Polydiacetylene (PDA) liposome microarrays are developed for selective and sensitive mercury (Hg2+) detection. The PDA sensors designed to produce red fluorescence emission upon binding with Hg2+, when the ssDNA aptamers on surface recognize wrap around ions resulting bulky T-Hg-T complexes repulse each other. Detailed facts of importance specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by...
The colorimetric reversibility of polydiacetylene supramolecules, derived from a variety functionalized diacetylenic lipids, has been subjected to detailed investigation. In an earlier effort, it was shown that vesicles prepared PCDA-mBzA 1, bearing terminal m-carboxyphenylamido groups, display complete upon thermal stimulation [J. Am. Chem. Soc. 2003, 125, 8976]. origin and nature reversible thermochromism in these systems have elucidated in-situ the current studies by using analogues 1....
Self-assembled diacetylene vesicles were spotted and immobilized on aldehyde-modified glass substrates using conventional microarray technology. Irradiation of the diacetylenes allowed generation nonfluorescent "blue-phase" polydiacetylene (PDA) arrays. Specific interaction PDA vesicle arrays with carbohydrates or poly(acrylic acid) solutions afforded fluorescent profiles.
Abstract Rationally designed polydiacetylene (PDA) molecules have been developed for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate (OP) nerve agents, a mass destruction weapon. Oxime (OX) functionality was incorporated into diacetylene to utilize its strong affinity toward organophosphates. The having an OX functional group (OX‐PDA) were self‐assembled form PDA liposomes in aqueous solution. Upon exposure agent simulants, at the OX‐PDA liposome surface...
Although microRNA (miRNA) expression levels provide important information regarding disease states owing to their unique dysregulation patterns in tissues, translation of miRNA diagnostics into point-of-care (POC) settings has been limited by practical challenges. Here, we developed a hydrogel-based microfluidic platform for colorimetric profiling miRNAs, without the use complex external equipment fluidics and imaging. For sensitive reliable measurement risk sequence bias, employed gold...
A novel fabrication method of monophasic, biphasic, and triphasic alginate microparticles having sensory polydiacetylene (PDA) liposomes has been developed to achieve selective more sensitive multitargeting detection in solution. In this microparticle based system, the PDA are concentrated particles rather than being diluted a solution, which is case conventional solution providing superior sensitivity stability. The biphasic nature was realized by coinjecting two different liposome/alginate...
We report a convenient melamine detection system based on polydiacetylene (PDA) liposomes having rapid, selective, and sensitive detection, dual signal capabilities. The limit of the sensory PDA liposome is 1 0.5 ppm in colorimetric fluorescence schemes, respectively, satisfying world regulation level.
Predictable tuning of bulk mechanics from the molecular level remains elusive in many physical hydrogel systems because reliance on nonspecific and nonstoichiometric chain interactions for network formation. We describe a mixing-induced two-component (MITCH) system, which assembly is driven by specific stoichiometric peptide–peptide binding interactions. By integrating protein science methodologies with simple polymer physics model, we manipulate polypeptide demonstrate direct ability to...
Abstract Target size effect on the sensory signaling intensity of polydiacetylene (PDA) liposome microarrays was systematically investigated. Influenza A virus M1 peptide and antibody were selected as a probe–target pair. While red fluorescence from PDA observed when larger used target, same probe to detect smaller signal did not appear. The results reveal that is mainly related steric repulsion between complexes strength binding force. Based this finding, we devised system directly detects...
High-throughput fabrication of graphically encoded hydrogel microparticles is achieved by combining flow contact lithography in a multichannel microfluidic device and high capacity 25 mm LED UV source. Production rates chemically homogeneous particles are improved two orders magnitude. Additionally, the custom-built instrument provides an affordable solution for patterning complex microstructures on surfaces.
We present polydiacetylene (PDA) liposome assemblies with various phospholipids that have different headgroup charges and phase transition temperatures (Tm). 10,12-Pentacosadiynoic acid (PCDA)-epoxy was used as a base PDA monomer the insertion of highly charged resulted in notable changes size reduction aggregation liposome. Among phospholipids, phospholipid moderate Tm demonstrated enhanced stability sensitivity, measured by zeta potential over storage time, thermochoromic response,...
An alternative signal transduction mechanism of polydiacetylene (PDA) sensors is devised by combining stimuli-responsive polymer hydrogel as a matrix and PDA sensory materials signal-generating component. We hypothesized that volumetric expansion the means external stimuli can impose stress on imbedded materials, generating signal. assembly component was ionically linked with alginate in order to transfer force efficiently molecules. Under same swelling ratio hydrogel, gel having embedded...
Solar energy conversion has emerged as an attractive pathway in the decomposition of hazardous organic pollutants. Herein, tridoped β-NaYF4:Yb3+,Tm3+,Gd3+ upconversion (UC) nanorods were embedded a carbon-doped mesostructured TiO2 hybrid film using triblock copolymer P123 acting mesoporous template and carbon source. The photoactivity our novel material was reflected degradation nitrobenzene, representative waste. broad-band absorption rationally designed UC nanorod-embedded C-doped UV to...
Although the unique optical signaling properties of polydiacetylene (PDA) have been exploited in diverse bio-chemosensors, practical application most PDA sensor systems is limited by their instability harsh environments and fluorescence signal weakness. Herein, a universal design principle for highly stable system with dual capability developed to detect cyanide (CN) ions, which are commonly found drinking water. Effective metal intercalation enhanced hydrophobic intermolecular interactions...
Taurine is ubiquitously distributed in mammalian tissues, with the highest levels brain, heart, and leukocytes. reacts hypochlorous acid (HOCl) to produce taurine chloramine (Tau-Cl) via myeloperoxidase (MPO) system. In this study, we elucidated antioxidative protective effects of Tau-Cl astrocytes. increased expression nuclear translocation factor E2-related (Nrf2) Nrf2-regulated antioxidant genes, including heme oxygenase 1 (HO-1). Nrf2 activity negatively regulated by Kelch-like...