A5089210672- Immune Response and Inflammation
- Trauma Management and Diagnosis
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Bone fractures and treatments
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Medical Practices and Rehabilitation
- Cell death mechanisms and regulation
- Cardiac Arrest and Resuscitation
- Hip and Femur Fractures
- Musculoskeletal Disorders and Rehabilitation
- Pleural and Pulmonary Diseases
- Congenital Diaphragmatic Hernia Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Phagocytosis and Immune Regulation
- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Complement system in diseases
- Knee injuries and reconstruction techniques
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2025
Universitätsklinikum Erlangen
2019-2025
Universität Ulm
2007-2021
Berufsgenossenschaftliche Unfallklinik Murnau
2014-2019
Rhode Island Hospital
2005-2016
Brown University
2005-2016
Deutsche Forschungsgemeinschaft
2010-2016
Heidelberg University
2016
University Hospital Ulm
2008-2014
Albert Einstein College of Medicine
2013
After severe tissue injury, innate immunity mounts a robust systemic inflammatory response. However, little is known about the immediate impact of multiple trauma on early complement function in humans. In present study, we hypothesized that results activation, consumption, and dysfunction cascade resulting "complementopathy" may be associated with morbidity mortality. Therefore, prospective multicenter study 25 healthy volunteers 40 polytrauma patients (mean injury severity score = 30.3 ±...
Indirect acute lung injury (ALI) is associated with high morbidity and mortality. No specific therapies have been developed, because the underlying pathophysiological processes remain elusive. To investigate contribution of Fas-induced apoptotic nonapoptotic/inflammatory signaling to pathology indirect ALI. A mouse model ALI, induced by successive exposure hemorrhagic shock cecal ligation puncture, was used. Quantification active caspase-3 short splice variant FLICE-inhibitory protein,...
Background Although finger joint capsulitis has been described among the most frequent injuries in climbers, no clinical studies on treatment strategies and outcomes are available. Study design Prospective case series study. Methods Between 2015 2018 we prospectively treated 50 patients (38 male, 12 female) with a total number of 69 independent according to clinic specific regimen evaluated outcome retrospectively. Therapy consisted either conservative management, steroid injections,...
Acute lung injury (ALI) is identified with the targeting/sequestration of polymorphonuclear leukocytes (PMN) to lung. Instrumental PMN targeting are chemokines [e.g., macrophage inflammatory protein-2 (MIP-2), keratinocyte-derived chemokine (KC), etc.] produced by macrophage, PMN, and other resident pulmonary cells. However, relative contribution macrophages as opposed in inducing ALI poorly understood. We therefore hypothesize that depletion peripheral blood and/or oblation a...
Severe blunt chest trauma remains an important injury with high morbidity and mortality. However, the associated immunological alterations are poorly understood. Existing big animal models require large-scale settings, often too expensive, research products for studies limited. In this study we aimed to establish a new model of blunt, isolated bilateral in mice characterize its effects on physiological inflammatory variables. Male C3H/HeN (n = 9–10/group) were anesthetized femoral artery was...
Abstract Lung injury in trauma patients exposed to a secondary infectious/septic challenge contributes the high morbidity/mortality observed this population. Associated pathology involves dys-regulation of immune function, specifically, sequestration activated polymorphonuclear neutrophils (PMN) lungs. The targeting PMN is thought involve release chemokines from cells within local environment, creating concentration gradient along which migrate focus inflammation. Keratinocyte-derived...
During experimental sepsis, excessive generation of the anaphylatoxin C5a results in reduction receptor (C5aR) on neutrophils. These events have been shown to result impaired innate immunity. However, regulation and fate C5aR neutrophils during sepsis are largely unknown. In contrast 30 healthy volunteers, 60 patients septic shock presented evidence complement activation with significantly increased serum levels C3a, C5a, C5b-9. group, corresponding decrease hemolytic activity distinguished...
More than 50% of severely injured patients have chest trauma. Second insults frequently result in acute lung injury (ALI), with sepsis being the main underlying condition. We aimed to develop a standardized, reproducible, and clinically relevant double-hit mouse model ALI induced by trauma polymicrobial investigate pathophysiologic role activated neutrophils. Lung contusion was applied C57Bl/6 mice via focused blast wave. Twenty-four hours later, cecal ligation puncture. For...
Abstract Background Rib and sternum fractures are common injuries associated with cardiopulmonary resuscitation (CPR). The fracture mechanism is either direct by application of force on anterior ribs or indirect bending through compression the thorax. aim this study was to determine morphologies rib after CPR reevaluate prior findings localisation, type degree dislocation. Methods present based all inpatients treated for chest wall non traumatic cardiac arrest at a Level 1 Trauma Centre from...
Introduction Injuries to the epiphyseal plate are of great concern as they can affect bone growth. Although fractures common in adolescents, distal femoral rare. Case presentation We present a case Salter–Harris type 1 fracture epiphysis femur that was self-inflicted by patient with paraplegia due spina bifida. The brought pediatrician's attention during routine checkup an apparent swelling right thigh. Upon presentation, we performed radiograph and additional MRI, which revealed partial...
ABSTRACT Background Assistance tools for intraoperative 2D and 3D imaging to decrease acquisition effort improve assessment of image data were evaluated. Methods Two automated optimisation procedures evaluated in a cadaver (Cios Spin, Siemens, Germany): The ScrewScout function assisted pedicle screw assessment. Then, an algorithm metal artefact reduction (MAR). Additionally, tool simplified setting contrast brightness was regarding the result elapsed time. Results time required without...
The aim of this prospective study was to determine the local concentrations inflammatory mediators in various tissue types frequently affected by trauma estimate role prestored cytokine release mechanical induction a systemic response syndrome. degree damage, evaluated its mediators, represents an important factor concerning outcome patients. Clinical trials indicate that kind traumatized influences pattern measured patients blood afterwards. However, tissue-specific mediator composition...
Objective and Design: Pulmonary contusion is frequently followed by acute respiratory distress syndrome, pneumonia, sepsis. However, immunologic alterations of circulating resident immune cell populations contributing to the posttraumatic immunosuppression are poorly understood. We therefore characterized influence pulmonary on peripheral blood mononuclear cells, peritoneal macrophages, splenocytes, splenic macrophages. To address significance associated with lung contusion, we investigated...
The inflammatory response after severe blunt chest trauma often leads to acute lung injury and respiratory distress syndrome which are associated with high mortality rates. Whereas the role of innate immunity in has been broadly investigated, immune is still poorly understood. Therefore, complement neutrophils was determined bilateral induced by a single blast wave. following time-points were investigated posttrauma: sham, 1, 6, 12, 24 h. There time-dependent systemic activation as CH-50...
Gut epithelial apoptosis is involved in the pathophysiology of multiple diseases. This study characterized intestinal three mechanistically distinct injuries with different kinetics cell death. FVB/N mice were subjected to gamma radiation, Pseudomonas aeruginosa pneumonia or injection monoclonal anti-CD3 antibody and sacrificed 4, 12, 24 hours post-injury (n=10/time point). Apoptosis was quantified jejunum by hematoxylin eosin (H&E), active caspase-3, terminal deoxynucleotidyl transferase...
Alveolar type 2 (AT-2) cell apoptosis is an important mechanism during lung inflammation, injury, and regeneration. Blunt chest trauma has been shown to activate inflammatory cells such as alveolar macrophages (AMs) or neutrophils (polymorphonuclear granulocytes [PMNs]), resulting in response. The present study was performed determine the capacity of different components/cells compartment (AMs, PMNs, bronchoalveolar lavage [BAL] fluids) induce AT-2 following blunt trauma. To this, male...
BACKGROUND The exact alterations of the immune system after polytrauma leading to sepsis and multiple-organ failure are poorly understood. Thus, early local systemic inflammatory apoptotic response was characterized in a new model compared with seen single or combined injuries. METHODS Anesthetized C57BL/6 mice were subjected either blunt bilateral chest trauma (Tx), closed head injury, right femur fracture including contralateral soft tissue combination injuries (PTx). After 2 hours 6...