A5075353839- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Protease and Inhibitor Mechanisms
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Plant responses to elevated CO2
- Abdominal vascular conditions and treatments
- Renal and Vascular Pathologies
- Photorefractive and Nonlinear Optics
- Electromagnetic Compatibility and Noise Suppression
- Laser Material Processing Techniques
- Infectious Aortic and Vascular Conditions
- Kawasaki Disease and Coronary Complications
- Plant Water Relations and Carbon Dynamics
- Thermography and Photoacoustic Techniques
- Advanced DC-DC Converters
- Historical and Architectural Studies
- Blood disorders and treatments
- Advanced Neuroimaging Techniques and Applications
Sint Franciscus Gasthuis
2022
Erasmus MC
2011-2021
The University of Sydney
2015-2016
Erasmus University Rotterdam
2011-2013
Radboud University Nijmegen
2013
University Health Network
2013
University of Toronto
2013
Universitair Ziekenhuis Leuven
2013
Scunthorpe General Hospital
2012
Charles University
2012
Aneurysms-osteoarthritis syndrome (AOS) is a new autosomal dominant syndromic form of thoracic aortic aneurysms and dissections characterised by the presence arterial tortuosity, mild craniofacial, skeletal cutaneous anomalies, early-onset osteoarthritis. AOS caused mutations in SMAD3 gene.A cohort 393 patients with without mutation FBN1, TGFBR1 TGFBR2 was screened for SMAD3. The originated from Netherlands, Belgium, Switzerland USA. clinical phenotype total 45 eight different families...
The Loeys–Dietz syndrome (LDS) is a connective tissue disorder affecting the cardiovascular, skeletal, and ocular system. Most typically, LDS patients present with aortic aneurysms arterial tortuosity, hypertelorism, bifid/broad uvula or cleft palate. Initially, mutations in transforming growth factor-β (TGF-β) receptors (TGFBR1 TGFBR2) were described to cause LDS, hereby leading impaired TGF-β signaling. More recently, ligands, TGFB2 TGFB3, as well intracellular downstream effectors of...
A high-frequency power transformer using multilayer printed circuit board (ML-PCB) technology is presented for applications in switched-mode supplies operating at frequencies up to several megahertz. The mechanical configuration of laboratory prototypes discussed, as well the electrical, parasitic, and thermal behavior. focus on leakage inductance, since analysis other aspects relatively simple. Test results show that has high efficiency, low good behavior, line insulation properties....
Discrete subaortic stenosis is notable for its unpredictable hemodynamic progression in childhood and high reoperation rate; however, data about adulthood are scarce.Adult patients who previously underwent surgery discrete were included this retrospective multicenter cohort study. Mixed-effects joint models used to assess the postoperative of aortic regurgitation, as well reoperation. A total 313 at 4 centers (age baseline, 20.2 years [25th-75th percentile, 18.4-31.0 years]; 52% male)....
Discrete subaortic stenosis (DSS) is often diagnosed early in life and known for its sometimes rapid haemodynamic progression childhood strong association with aortic regurgitation (AR). However, data about the evolution of DSS adulthood are scarce. Therefore, we aimed to evaluate natural history DSS, identify risk factors AR, intervention-free survival. Conservatively managed adult patients were included this retrospective multicentre cohort study. Mixed-effects joint models used assess...
Objectives/Background Congenital aortic stenosis ( AS ) is the most common obstructive left heart lesion in young adult population and often complicated by dilatation. Our objective was to evaluate accuracy of imaging with transthoracic echocardiography TTE compared cardiac magnetic resonance CMR ). Methods Aortic diameters were measured at 4 levels . Agreement concordance assessed P earson's correlation B land– A ltman analysis. Results Fifty‐nine patients (age 33 ± 8 years; 66% male)...
Marfan syndrome (MFS) and familial non-syndromal thoracic aortic aneurysm dissection (ns-TAAD) are genetic aortopathies causing dilatation with increased stiffness. Left ventricular (LV) contractility ventricular-vascular coupling index (VVI) were compared between MFS ns-TAAD determinants of VVI investigated.Patients (M 57, F 47) 72, 39) studied by echocardiography controls 77, 71). Aortic geometry, hemodynamics, LV work, (end-systolic elastance [Ees]), documented. sinuses equally dilated in...
Patients treated with anthracyclines and trastuzumab are at increased risk of developing heart failure. Early diagnosis treatment may prevent irreversible left ventricular (LV) dysfunction. This study investigates whether subclinical deterioration global longitudinal strain (GLS) is a more reliable early predictor for LV dysfunction than three-dimensional (3D) ejection fraction (LVEF).Adult patients receiving breast cancer who had serial echocardiographic follow-up were included in this...