A5001599527- Nanoplatforms for cancer theranostics
- Physiological and biochemical adaptations
- Surface Modification and Superhydrophobicity
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Protein purification and stability
- biodegradable polymer synthesis and properties
- nanoparticles nucleation surface interactions
- Freezing and Crystallization Processes
- Graphene and Nanomaterials Applications
- Additive Manufacturing and 3D Printing Technologies
- Polymer Surface Interaction Studies
- Magnesium Oxide Properties and Applications
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Innovative Microfluidic and Catalytic Techniques Innovation
- Monoclonal and Polyclonal Antibodies Research
- Diatoms and Algae Research
- Advanced Polymer Synthesis and Characterization
- Antibiotics Pharmacokinetics and Efficacy
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Ferroelectric and Piezoelectric Materials
- Lanthanide and Transition Metal Complexes
University of Colorado Boulder
2019-2022
University of Colorado System
2021
Case Western Reserve University
2013-2018
Case Comprehensive Cancer Center
2017
Case Engineering (United States)
2017
Blending thermoplastic polyurethane (TPU) with poly(lactic acid) (PLA) is a proven method to achieve much more mechanically robust material, whereas the addition of graphene oxide (GO) increasingly applied in polymer nanocomposites tailor further their properties. On other hand, additive manufacturing has high flexibility structure design which can significantly expand application materials many fields. This study demonstrates fused deposition modeling (FDM) 3D printing TPU/PLA/GO and its...
Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field biopharmaceuticals. The most common and long-standing polymer modification attachment methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led several clinically approved pharmaceuticals. Recent data indicate that brush-type significantly enhance vitro vivo properties. Herein, conformation poly(ethylene detailed compared with those polyacrylate polynorbornene (PNB)...
The antibiotic erythromycin has limited efficacy and bioavailability due to its instability conversion under acidic conditions via an intramolecular dehydration reaction. To improve the stability of erythromycin, several analogs have been developed-such as azithromycin clarithromycin-which decrease rate dehydration. We set out build upon this prior work by developing a conjugate with improved pH stability, bioavailability, preferential release from drug delivery system directly at low...
This review describes fundamental contributions in the area of proteins as macroinitiators and macro-chain transfer agents (CTA) for controlled radical polymerization (CRP). The specifically highlights concept 'grafting-from' proteins, new efficient chemistry has been developed to polymerize directly from protein substrates aqueous media. As past ten years have shown, CRP proven a powerful tool functionalization proteins. considers methods used install based initiators CTAs, principle...
Viral nanoparticles have been utilized as a platform for vaccine development and are versatile system the display of antigenic epitopes variety disease states. However, induction clinically relevant immune response often requires multiple injections over an extended period time, limiting patient compliance. Polymeric systems to deliver proteinaceous materials extensively researched provide sustained release, which would limit administration single dose. Melt-processing is emerging...
Improved imaging of cancerous tissue has the potential to aid prognosis and improve patient outcome through longitudinal treatment response disease progression. While nuclear made headway in cancer imaging, fluorinated tracers that enable magnetic resonance (19F MRI) hold promise, particularly for repeated sessions because nonionizing radiation is used. Fluorine MRI detects molecular signatures by a tracer takes advantage spatial anatomical resolution afforded MRI. This manuscript describes...
Fluorous nanoparticles enhances oxygen uptake as a PDT carrier for skin cancers.
Polymeric nanoparticles have emerged as valuable drug delivery vehicles they improve solubility of hydrophobic drugs, enhance circulation lifetime, and can the biodistribution profile small-molecule therapeutics. These take on a host polymer architectures including polymersomes, hyperbranched nanoparticles, dendrimers. We recently reported that simple low molecular weight fluorous copolymers self-assemble into show exceptional passive targeting multiple tumor models. Given favorable these...
A simple photochemical modification scheme is utilized to fabricate multifunctional and patterned coextruded fibers.
The ability of a natural ice-binding protein from Shewanella frigidimarina (SfIBP) to inhibit ice crystal growth in highly alkaline solutions with increasing pH and ionic strength was investigated this work. purity isolated SfIBP first confirmed via sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) size-exclusion chromatography an ultraviolet detector (SEC-UV). Protein stability evaluated the using circular dichroism spectroscopy, SEC-UV, SDS-PAGE. recrystallization...
Abstract This study investigates critical factors affecting polymer‐assisted sol‐gel synthesis of synthetic aluminosilicate powders that can be alkali‐activated to produce a sodium‐stabilized hydrate (N‐A‐S‐H) geopolymer cement. More specifically, 2 factorial experiment was conducted elucidate the influence polymer architecture (ie, poly(ethylene glycol) (PEG) vs poly(vinyl alcohol) (PVA)), content low high ion‐to‐polymer‐oxide (I/O) atomic ratio), and aging pH conditions high) on structure...
Ice growth mitigation is a pervasive challenge for multiple industries. In nature, ice-binding proteins (IBPs) demonstrate potent ice prevention through recrystallization inhibition (IRI). However, IBPs are expensive, difficult to produce in large quantities, and exhibit minimal resilience nonphysiological environmental stressors, such as pH. For these reasons, researchers have turned bioinspired polymeric materials that mimic IBP behavior. To date, however, no synthetic polymer has rivaled...
Ice growth mitigation is a pervasive challenge for multiple industries. In nature, ice-binding proteins (IBPs) demonstrate potent ice-growth prevention through ice recrystallization inhibition (IRI). However, IBPs are expensive, difficult to produce in large quantities, and exhibit minimal resilience non-physiological environmental stressors, such as elevated pH. For these reasons, researchers have turned polymeric bioinspired mimics. To-date, however, no mimic has rivaled the ability of...
Ice growth mitigation is a pervasive challenge for multiple industries. In nature, ice-binding proteins (IBPs) demonstrate potent ice-growth prevention through ice recrystallization inhibition (IRI). However, IBPs are expensive, difficult to produce in large quantities, and exhibit minimal resilience non-physiological environmental stressors, such as elevated pH. For these reasons, researchers have turned polymeric bioinspired mimics. To-date, however, no mimic has rivaled the ability of...