A5102860732- Neuroscience and Neuropharmacology Research
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Phosphodiesterase function and regulation
- Hepatitis C virus research
- Asthma and respiratory diseases
- Lung Cancer Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Traditional Chinese Medicine Analysis
- Thermography and Photoacoustic Techniques
- Hepatitis B Virus Studies
- Anesthesia and Neurotoxicity Research
- Analytical Chemistry and Sensors
- Biological and pharmacological studies of plants
- Mast cells and histamine
- Gas Sensing Nanomaterials and Sensors
- Eicosanoids and Hypertension Pharmacology
- Infrared Target Detection Methodologies
- Neurological Disease Mechanisms and Treatments
- Metastasis and carcinoma case studies
- Heme Oxygenase-1 and Carbon Monoxide
- Sepsis Diagnosis and Treatment
- Advanced Sensor Technologies Research
- Alcohol Consumption and Health Effects
- Phagocytosis and Immune Regulation
Taipei Medical University Hospital
2010-2020
Taipei Medical University
2007-2020
Koo Foundation Sun Yat-Sen Cancer Center
2014
Chinese Academy of Sciences
1984
One concern to the patients is off-line detection of pneumonia infection status after using ventilator in intensive care unit. Hence, machine learning methods for ventilator-associated (VAP) rapid diagnose are proposed. A popular device, Cyranose 320 e-nose, usually used research on lung disease, which a highly integrated system and sensor comprising 32 array polymer carbon black materials. In this study, total 24 subjects were involved, including 12 who infected with pneumonia, rest...
To investigate the influence of different ventilatory supports on predictive performance breathing pattern variability for extubation outcomes in intensive care unit patients.A prospective measurement retrospectively analyzed a medical center.Sixty-eight consecutive and ready-for-weaning patients were divided into success (n=45) failure (n=23) groups based their outcomes.Breath-to-breath analyses peak inspiratory flow, total breath duration, tidal volume, rapid shallow index performed three...
Background: The relationship between the various cytokine responses that occur during sepsis remains controversial. Emerging evidence indicates proinflammatory and anti-inflammatory are regulated simultaneously from beginning of sepsis. However, roles novel mediators annexin (Anx)A1 lipoxin (LX)A4 cytokines neutrophil gelatinase-associated lipocalin (NGAL) macrophage inflammatory protein (MIP)-3a have been studied. Methods: In this study, plasma levels AnxA1, LXA4, NGAL, MIP-3a, interleukin...
ABSTRACT In Taiwan, we found two hepatitis B virus (HBV)‐ and C (HCV)‐endemic townships, Paisha Tzukuan, with an anti‐HCV prevalence of 19 37% in men, 26 38% women, respectively. The surface antigen (HBsAg)‐positive rates were 25 18%, for men women Paisha, 22% According to the national death certification database (1982 1991), annual age‐adjusted mortality per 100 000 population liver cancer among 83.0 13.8, respectively, 55.9 17.0 Tzukuan compared 30.9 9.1 Taiwan as a whole. male‐to‐female...
Abstract In the present study, we explore role of apoptosis signal-regulating kinase 1 (ASK1) in denbinobin-induced human lung adenocarcinoma (A549) cells. Denbinobin-induced cell was attenuated by an ASK1 dominant-negative mutant (ASK1DN), two antioxidants (N-acetyl-L-cysteine (NAC) and glutathione (GSH)), a c-Jun N-terminal (JNK) inhibitor (SP600125), activator protein-1 (AP-1) (curcumin). Treatment A549 cells with denbinobin caused increases activity reactive oxygen species (ROS)...
The aim of the study was to elucidate epidemiological features Hepatitis C virus (HCV) infection among teenagers in an endemic area by conducting a mass screening study. We also investigated clinical outcome anti-HCV-positive subjects subsequent short-term and long-term follow-up studies. All 2837 students two junior middle schools Tzukuan, aged 13–16 years, were invited be screened for anti-HCV, HBsAg, AST ALT October 1995. A total 2726 (96%) responded. Anti-HCV, HCV RNA aminotransferase...
Hesperetin, a selective phosphodiesterase (PDE)4 inhibitor, is present in the traditional Chinese medicine, “Chen Pi.” Therefore, we were interested investigating its effects on ovalbumin- (OVA-) induced airway hyperresponsiveness, and clarifying rationale for ameliorating asthma chronic obstructive pulmonary disease (COPD). Hesperetin was revealed to have therapeutic (PDE4 H /PDE4 L ) ratio of >11. (10 ~ 30 μmol/kg, intraperitoneally (i.p.)) dose-dependently significantly attenuated...
Hesperetin-5,7,3'-O-trimethylether (HTME), a synthetic liposoluble hesperetin, has been reported to be dual phosphodiesterase (PDE)3/4 inhibitor. We investigated its inhibitory effects on methacholine (MCh)-induced airway hyperresponsiveness (AHR) and potential for treating atypical asthma COPD.FlexiVent system was used determine AHR in ovalbumin (OVA) sensitized challenged mice. Determination of cytokines performed by using mouse T helper (Th)1/Th2 cytokine CBA kits, total immunoglobulin...
Phagocytic clearance of apoptotic neutrophils by tissue macrophages is a crucial component in the resolution phase acute inflammation. However, number low and not likely to cope satisfactorily with excess dying neutrophils. Although recent studies have reported that are able engulf neutrophils, mechanisms which living attracted poorly defined. Increased amounts CX3CL1 microparticles (MPs) rapidly released cells, involved chemoattraction mononuclear phagocytes toward cells. The current study...
In traditional Chinese medicine (TCM), a combination of kudzu and Chen-Pi is frequently prescribed for relieving colds, fever, bronchitis, cough. It contains daidzein hesperetin, selective inhibitors family 3 (PDE3), 4 (PDE4) phosphodiesterases (PDEs), respectively. passively sensitized human airways, allergen-induced contraction was reported to be inhibited only by the simultaneous inhibition PDE3 PDE4, but not single either isozyme. Therefore, we are interested in investigating interaction...
A clear and positive correlation between the CO2 concentration blood-sugar level has been observed via a non-invasive time-dependent monitoring of from human breath, which is carried out by using home-made gas chromatography (GC)/milli-whistle compact analyzer. The sampling correlated 5.0 to 5.6% (1% = 104 ppm) in accordance with variations 80 110 mg/dL. analytical method results rapid, continuous determination measurement exhaled lungs.
A 62-year-old man was admitted to our hospital with a concern of productive cough, profuse hemoptysis, and intermittent breathlessness for about 5 months. He had 50-year history cigarette smoking stopped months prior being seen.
The rhizome of Ligusticum chuaxiong Hort. (Umbelliferae) has been used by Chinese for several thousand years. Its main constituent, butylidenephthalide (Bdph), was proved to be active in inhibiting rat uterine contractions induced prostaglandin F2α and reported a nonspecific antispamodic blocker voltage-dependent Ca2+ channels (VDCCs).The present study investigates the mechanisms Bdph twitch facilitation ICR mouse vas deferens (MVD).Electrical field stimulation (EFS, supramaximal voltage...
In this study, an electronic nose is used to record breathing data from healthy and pneumonia patients.The records resistance using a microarray of 11 sensors made metal oxide semiconductor.The recorded are fed artificial neural network (ANN), which train model for the detection infections.Initially, five patients' construct ANN model.Then, another two test accuracy model.In preliminary achieved good results, showing that it can be further developed into efficient online system in near future.
Objectives: Single-incision thoracoscopic surgery for lung cancer has been proposed as a feasible approach in surgery. Reducing postoperative pain is one of the potential benefits single-incision over conventional two- or three-port incision We aim to compare level between patients undergoing and two-incision lobectomy our institute. Methods: From November 2011 June 2013, 50 underwent pulmonary resection cancer. Among them, 35 lobectomy. January 2005 195 160 All surgeries were done by...