A5002193071- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Gut microbiota and health
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
Lund University
2022
Singapore Immunology Network
2021
Agency for Science, Technology and Research
2021
University of Bonn
2021
APC Microbiome Institute
2021
University College Cork
2021
Type 1 conventional dendritic cells (cDC1s) are rare immune critical for the induction of antigen-specific cytotoxic CD8 + T cells, although genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce fate in mouse fibroblasts, but reprogramming somatic was limited by low efficiency. Here, we investigated single-cell transcriptional dynamics during reprogramming. Human induced cDC1s...