A5045631598- Amyotrophic Lateral Sclerosis Research
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Spinal Cord Injury Research
- Alzheimer's disease research and treatments
- Traumatic Brain Injury Research
University of Massachusetts Chan Medical School
2023
UMass Memorial Medical Center
2022
VA Boston Healthcare System
2020-2022
Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic encephalopathy (CTE) amyotrophic lateral sclerosis (ALS). ALS CTE distinct disorders, yet in some instances, share pathology, affect similar regions, occur together. The pathways involved biomarkers diagnosis of both largely unknown. MicroRNAs (miRNAs) gene regulation may be altered neurodegeneration useful as stable biomarkers. Thus, we set out to determine associations...
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both the upper and lower motor neurons. Although ALS typically leads to death within 3 5 years after initial symptom onset, approximately 10% of patients with live more than 10 onset. We set out determine similarities differences in clinical presentation neuropathology persons long vs. those standard duration. Participants were United States military Veterans pathologically confirmed diagnosis...
The amyotrophic lateral sclerosis (ALS) functional rating scale-revised (ALSFRS-R) is commonly used to track ALS disease progression; however, there are gaps in the literature regarding extent which ALSFRS-R relates underlying central nervous system (CNS) pathology. current study explored association between (total and subdomain) scores postmortem neuropathology (both ALS-specific comorbid disease).Within our sample of 93 military veterans with autopsy-confirmed ALS, we utilized hierarchical...
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons, causing progressive muscle weakness and respiratory failure. The presence of an expanded hexanucleotide repeat in chromosome 9 open reading frame 72 ( C9ORF72 ) accounts for most cases familial ALS frontotemporal dementia (FTD). To determine if suppressing expression gene products can reduce toxicity, we designed set artificial microRNAs (amiRNA) targeting the human gene. Here report...