A5037164750- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury Research
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Marine and coastal plant biology
- Amyotrophic Lateral Sclerosis Research
- Fungal and yeast genetics research
- Medical Imaging and Pathology Studies
- Melanoma and MAPK Pathways
- Genomics and Chromatin Dynamics
- Spinal Cord Injury Research
- Ubiquitin and proteasome pathways
- S100 Proteins and Annexins
- Genomics and Phylogenetic Studies
- Coral and Marine Ecosystems Studies
- Histone Deacetylase Inhibitors Research
Boston University
2019-2024
University School
2022
Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through nonmutational events. Although the epigenetic landscape is shown be altered in therapy-resistant melanomas and other cancers, a specific targetable mechanism has not been validated. Here, we evaluated corepressor for element 1-silencing transcription factor (CoREST) repressor complex recently developed bivalent inhibitor corin within context of phenotype plasticity therapeutic resistance....
Abstract Background The mechanisms underlying neurodegeneration in the striatum of Huntingon’s Disease (HD) brain are currently unknown. While is massively degenerated symptomatic individuals, which makes cellular characterization difficult, it largely intact asymptomatic HD gene positive (HD+) individuals. Unfortunately, as striatal tissue samples from HD+ individuals exceedingly rare, recent focus has been on Brodmann Area 9 (BA9), a relatively unaffected region, surrogate tissue. In this...
Repetitive head impacts (RHI) and traumatic brain injuries are risk factors for the neurodegenerative diseases chronic encephalopathy (CTE) amyotrophic lateral sclerosis (ALS). ALS CTE distinct disorders, yet in some instances, share pathology, affect similar regions, occur together. The pathways involved biomarkers diagnosis of both largely unknown. MicroRNAs (miRNAs) gene regulation may be altered neurodegeneration useful as stable biomarkers. Thus, we set out to determine associations...
Abstract Background Our understanding of the molecular underpinnings chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem brain is incomplete. Factors including years play genetic risk variants influence extent tau with disease expression, but how these factors affect gene whether those effects are consistent across development disease, unknown. Methods To address questions, we conducted an analysis largest CTE mRNASeq whole-transcriptome dataset available to...
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative tauopathy found in individuals with history of repetitive head impacts (RHI). Previous work has demonstrated that neuroinflammation involved CTE pathogenesis, however, the specific inflammatory mechanisms are still unclear. Here, using RNA-sequencing and gene set enrichment analysis (GSEA), we investigated genetic changes tissue taken from region pathology first found, cortical sulcus, compared it to neighboring gryal...
ABSTRACT The mechanisms underlying degeneration of the specific neurons in striatum Huntingon’s Disease (HD) brain are currently unknown. is massively degenerated late stage HD, making examination post-mortem tissue from symptomatic individuals problematic. Striatal largely intact brains asymptomatic HD positive (HD+) gene carriers, but these samples exceedingly rare. In this study, caudate nucleus (CAU) two HD+ was subjected to high throughput mRNA sequencing (mRNA-Seq) for comparison with...
Abstract Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through non-mutational events 1,2 . Although the epigenetic landscape has been shown be altered in therapy-resistant melanomas and other cancers 3,4 , a specific targetable mechanism regulating treatment not validated date. Here we evaluate CoREST repressor complex novel inhibitor, corin 5 within context of phenotype plasticity therapeutic order define mechanisms underlying these...
Abstract Historically, staghorn coral ( Acropora cervicornis ) was a preeminent reef-builder in the Caribbean and Tropical Western Atlantic, where it constructed extensive thickets at 5-20 m depth that supported diverse ecosystems provided coastal populations with food, storm protection, income from tourism. In recent decades, A. declined precipitously, up to 97% some localities. To reverse its decline, widespread efforts are underway characterize phenotypic genetic diversity of persisting...
ABSTRACT Our understanding of the molecular underpinnings chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem brain is incomplete. Factors including years play genetic risk variants influence extent tau with disease expression, but how these factors affect gene whether those effects are consistent across development disease, unknown. To address questions, we conducted an analysis largest mRNASeq whole-transcriptome dataset available to date. We examined genes...