A5102842536- Immunotherapy and Immune Responses
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Cancer-related Molecular Pathways
- Virus-based gene therapy research
- Cardiac and Coronary Surgery Techniques
- Genetic Associations and Epidemiology
- Cancer Research and Treatments
- Histone Deacetylase Inhibitors Research
- Health, Environment, Cognitive Aging
- Machine Learning in Healthcare
- Congenital heart defects research
- Functional Brain Connectivity Studies
- Cancer Cells and Metastasis
- AI in cancer detection
- Genomics and Chromatin Dynamics
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Hematopoietic Stem Cell Transplantation
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Angiogenesis and VEGF in Cancer
Boston University
2021-2024
Boston Medical Center
2021
Innovation Pharmaceuticals (United States)
2011
Brigham and Women's Hospital
1995
Harvard University
1995
Virtually all patients with BRAF-mutant melanoma develop resistance to MAPK inhibitors largely through nonmutational events. Although the epigenetic landscape is shown be altered in therapy-resistant melanomas and other cancers, a specific targetable mechanism has not been validated. Here, we evaluated corepressor for element 1-silencing transcription factor (CoREST) repressor complex recently developed bivalent inhibitor corin within context of phenotype plasticity therapeutic resistance....
A tumor-specific cytotoxic T lymphocyte (CTL) immune response has been well documented in melanoma, renal cell carcinoma, and ovarian cancer. Conflicting evidence exists regarding the existence of CTL populations breast Tumor cells tumor-associated lymphocytes (TAL) were isolated from pleural effusions six consecutive patients with metastatic After solid-phase anti-CD3 stimulation, TAL cultures expanded weekly autologous tumor stimulation low-dose IL-2 for 3 wk. characterized using flow...
Abstract We have previously shown that Kevetrin, a small molecule currently under development, has potent antitumor activity in human multi-drug resistant carcinoma xenograft models while being well tolerated. To investigate the mechanism of action for its activity, we assessed Kevetrin's effect on apoptosis, cell cycle progression, including underlying molecular mechanisms. Here report Kevetrin strongly induced arrest and apoptosis lung adenocarcinoma line (A549) using TUNEL assay FACS...
Abstract Mounting clinical and preclinical evidence demonstrates an important role for the intestinal microbiome in mediating efficacy of immune checkpoint inhibitor (ICI) antibody therapy across a number tumor contexts. We sought to determine effects modulation on ICI clinically recapitulative orthotopic murine lung cancer model. The C57Bl/6NHsd mice was sterilized with antibiotic (ampicillin, streptomycin colistin) ten days, resulting 99.9% mean decrease fecal aerobic anaerobic bacterial...
Abstract Humanized immune system (HIS) mice - immunocompromised Nod.Cg-Prkdcscid Il2rgtm1Wjl/SzJ animals in which the has been humanized by engraftment of CD34+ hematopoietic stem cells (HSC), peripheral blood mononuclear (PBMC), or other human cells/tissues represent an important tool pre-clinical oncology research. Here we investigated several pre-conditioning regimens (Busulfan pre-treatment total body irradiation (TBI)) to determine would yield maximum leukocyte and lineage diversity....