A5007799050- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Healthcare during COVID-19 Pandemic
- Antifungal resistance and susceptibility
- Inflammasome and immune disorders
- Pericarditis and Cardiac Tamponade
Instituto de Cancerología Las Américas
2014-2023
Hospital Infantil de México Federico Gómez
2010-2023
University of California, Los Angeles
2011-2019
Cranbrook Academy of Art
2015
APLA Health
2010-2011
Secretaria de Salud
2007
Center for Research and Advanced Studies of the National Polytechnic Institute
2005-2007
Mexican Social Security Institute
2002-2006
Centro Médico Nacional La Raza
2003
Centro de Investigación en Materiales Avanzados
2003
Haploidentical transplantation performed with post-transplantation cyclophosphamide (PTCy)–based graft-versus-host disease (GVHD) prophylaxis has been associated favorable outcomes for patients acute myeloid leukemia and lymphomas. However, it remains unclear if such approach is effective lymphoblastic (ALL). We analyzed of 109 consecutively treated ALL 18 years age older at 5 institutions. The median was 32 the follow-up survivors 13 months. Thirty-two were in first complete remission...
We previously developed an antibody-avidin fusion protein (ch128.1Av) targeting the human transferrin receptor 1 (TfR1, also known as CD71), which demonstrates direct in vitro cytotoxicity against malignant hematopoietic cells. This is attributed to its ability decrease level of TfR1 leading lethal iron deprivation. now report that ch128.1Av shows bind Fcγ receptors and complement component C1q, suggesting it capable eliciting Fc-mediated effector functions such antibody-dependent...
Arnica montana cell suspension culture could be a sustainable source of vegetal material producer secondary metabolites (SMs) possessing biological effects. Different plant growth regulator concentrations (0-5 mg/L) were tested in foliar explants to induce callus that was used establish culture. Growth kinetics carried out for 30 days. A methanolic extract obtained from biomass harvested at days fractionated, and three fractions bioactivities. We induced with 1 mg/L picloram 0.5 kinetin...
A number of antibodies have been developed that induce lethal iron deprivation (LID) by targeting the transferrin receptor 1 (TfR1/CD71) and either neutralizing (Tf) binding, blocking internalization and/or inducing its degradation. We recombinant human TfR1 (ch128.1 ch128.1Av), which degradation are cytotoxic to certain malignant B-cells. now show bound these can lead sequestration degradation, as well reduced Tf uptake, induction a transcriptional response consistent with deprivation, is...
The use of haploidentical donor hematopoietic stem cell transplantation with post-transplantation cyclophosphamide (Haplo-PTCy) in children is increasing; however, it still not clear which preparative regimen best this setting. We present the long-term results 42 patients age <18 years high-risk leukemia who underwent procedure using a reduced-intensity conditioning (RIC) and peripheral blood as source. Twenty-six had acute lymphoblastic leukemia, 13 myelogenous 2 juvenile myelomonocytic 1...
Despite all successful efforts to develop a COVID-19 vaccine, the need evaluate alternative antigens produce next-generation vaccines is imperative target emerging variants. Thus, second generation of employ more than one antigen from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induce an effective and lasting immune response. Here, we analyzed combination two SARS-CoV-2 viral that could elicit durable response in both T- B-cells. The nucleocapsid (N) protein, Spike protein...
The survival of patients with Non-Hodgkin´s Lymphoma has substantially improved current treatments. Nevertheless, the appearance drug-resistant cancer cells leads to patient relapse. It is therefore necessary find new antitumor therapies that can completely eradicate transformed cells. Chemotherapy-resistant are characterized by overexpression members anti-apoptotic Bcl-2 protein family, such as Bcl-XL, and Mcl-1. We have recently shown peptides derived from BH3 domain pro-apoptotic Bax...
Iron is essential for cell growth and imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on surface cell, then releases iron endosomes. TfR1 single pass type-II transmembrane expressed at basal levels most tissues. High expression typically associated with rapidly proliferating cells, including various types cancer. targeted by experimental therapeutics several reasons: accessibility, constitutive endocytosis role...
DNA priming-protein boosting is a strategy used to establish strong immunity specific pathogen by the use of two different antigens through sequential delivery systems. In this work, recombinant plasmids were used, one encoding for dengue virus E protein, which know induce neutralizing antibodies (pcDNA 3.1/E), and other Dengue nonstructural protein 1 3.1/NS1), as source B- T-cell epitopes possibly involved in protective immunity. We showed that immunization BALB/c mice with three priming...
Salmonella enterica es una especie de bacterias anaeróbicas facultativas que han sido empleadas con gran éxito como vector bacteriano vivo atenuado fines vacunales. Recientemente se ha documentado S. tiene propiedades importantes para ser considerada agente terapéutico contra el cáncer. Estudios preclínicos y clínicos demostrado coloniza tumores sólidos, semisólidos metástasis, además contribuye a disminuir la resistencia los tratamientos. En esta revisión aborda capacidad atenuada eliminar...
Tumor cell resistance to chemotherapy agents is one of the main problems in eradication different neoplasias. One mechanisms this process overexpression anti-apoptotic proteins such as Bcl-2 and Bcl-XL; blocking activity these may contribute sensitization tumor cells allow adequate effects chemotherapeutic drugs. This study adressed transfection prostate cancer (PC3) with a plasmid encoding recombinant protein an antagonist peptide from BH3 region Bax fused GFP reporter (BaxGFP). induced...
Summary CD154 is a type II glycoprotein member of the tumour necrosis factor (TNF) ligand family, which expressed mainly on surface activated T lymphocytes. The interaction with its receptor CD40, plays central role in control several functions immune system. Structural models based homology TNF and lymphotoxin indicate that binding to CD40 involves three regions surrounding amino acids K143, R203 Q220, strands W140–S149 S198–A210 are critical for such interactions. Also, it has been...