A5100776866- Photorefractive and Nonlinear Optics
- Photonic and Optical Devices
- Advanced Fiber Laser Technologies
- Solid State Laser Technologies
- Pregnancy and preeclampsia studies
- Thyroid Disorders and Treatments
- Congenital heart defects research
- Birth, Development, and Health
- Ferroelectric and Piezoelectric Materials
- Optical and Acousto-Optic Technologies
- RNA modifications and cancer
- Luminescence Properties of Advanced Materials
- MicroRNA in disease regulation
- Toxoplasma gondii Research Studies
- Crystal Structures and Properties
- Obsessive-Compulsive Spectrum Disorders
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Solid-state spectroscopy and crystallography
- Advanced MEMS and NEMS Technologies
- Reproductive System and Pregnancy
- Advanced Optical Imaging Technologies
- Cancer-related molecular mechanisms research
- Analytical Chemistry and Sensors
- Crystallization and Solubility Studies
Jiangxi Agricultural University
2022-2025
Affiliated Hospital of Qingdao University
2015-2024
Qingdao University
2012-2024
Nankai University
2013-2023
Fudan University
2006-2021
Wuhan University
2020
Hubei Zhongshan Hospital
2020
Shanxi University
2019
Xinxiang Medical University
2015-2016
Qingdao Center of Resource Chemistry and New Materials
2015
Abstract Gout is one of the most common types inflammatory arthritis, caused by deposition monosodium urate crystals in and around joints. Previous genome-wide association studies (GWASs) have identified many genetic loci associated with raised serum concentrations. However, hyperuricemia alone not sufficient for development gout arthritis. Here we conduct a multistage GWAS Han Chinese using 4,275 male patients 6,272 normal controls (1,255 cases 1,848 were genotyped), an additional 1,644...
Usage of lithium niobate in nonlinear optics is seriously hampered by optical damage, particular, where high intensity needed. Doping with magnesium can improve its resistance against damage. However, since a rather large dopant concentration required (more than 4.6mol% MgO) and the distribution coefficient unfavorable, it difficult to grow crystals quality. The authors show that doping zirconium, one obtain at same time higher lower threshold (only 2.0mol% ZrO2), near 1.0, low coercive...
The recent advances in the photorefraction of doped lithium niobate crystals are reviewed. Materials have always been main obstacle for commercial applications photorefractive holographic storage. Though iron-doped LiNbO3 is mainstay data storage efforts, several shortcomings, especially low response speed, impede it from becoming a recording medium. This paper reviews characteristics different dopants, tetravalent ions, and co-doped crystals, including Hf, Zr Sn monodoped LiNbO3, Hf Fe, Fe...
The complex pathogenesis of preeclampsia (PE), a significant contributor to maternal and neonatal mortality globally, is poorly understood despite substantial research. This review explores the involvement exosomal microRNAs (exomiRs) in PE, focusing on their impact protein kinase B (AKT)/hypoxia-inducible factor 1-α (HIF1α)/vascular endothelial growth (VEGF) signaling pathway as well cell proliferation migration. Specifically, this article amalgamates existing evidence reveal pivotal role...
African swine fever virus (ASFV) is a severe threat to the global pig industry, and domestic pigs mostly develop clinical manifestations upon viral invasion. Currently, there no available vaccine against ASFV. Its capsid structural protein p72 one of immuno-dominant proteins. In this study, we unexpectedly obtained mutant (p72∆377-428) which deleted aa 377-428 within had stable high expression in E. coli. Using SWISS-MODEL 1.0 software, prediction showed that p72∆377-428 was quite distinct...
In this study, we used a high-temperature solution to grow KBa2(PO3)5 (KBP), which is potential deep-ultraviolet (UV) nonlinear optical crystal. It congruent melting compound that solidifies in non-centrosymmetric crystal system monoclinic with the Pc space group. KBP exhibits powder second-harmonic response at 1064 nm incident radiation, an efficiency of 0.9 × KDP. wide transparency range, as cutoff absorption edge UV region short 167 nm. addition, performed Raman and IR spectroscopies on...
Highly HfO2 doped lithium niobate crystals have been grown. The experimental results indicate that LiNbO3:Hf (up to 4 mol%) can withstand the same light intensity, of 5 × 105 W cm−2, as LiNbO3:Mg (6.5 mol%). And OH− absorption bands these shift 3487 cm−1 from 3484 for congruent pure LiNbO3. difference spectra and fitting treatments show peak corresponding (HfNb4+)−–OH− is located at 3500 cm−1.
Photorefractive properties of congruent lithium niobate crystals codoped with HfO2 and Fe2O3 were investigated it was found that Fe ions are still located at Li sites as photorefractive centers when the doping concentration goes above threshold value. As a result, their response speed sensitivity significantly enhanced. Meanwhile, high saturation diffraction efficiency is maintained. Experimental results definitely show Hf now most effective element for LiNbO3:Fe crystal to improve its properties.
Applications of lithium niobate in nonlinear optics at high light intensities are seriously hampered by optical damage. Recent investigations have shown that Hf(4+) and Zr(4+) ions some advantages suppressing damage LiNbO(3) with respect to Mg(2+). Here we present Sn-doped (Sn:LN). Experimental results indicate Sn:LN has similar resistance Mg-doped LiNbO(3), but the doping threshold Sn is only 2.5 mol.%, where its distribution coefficient 0.98. Hence Sn(4+) ion turns out be another good...
The aim of this study was to screen for DUOX2, TPO and TG mutations in Chinese patients with congenital hypothyroidism (CH) goitre define the relationships between DUOX2 genotypes clinical phenotypes.Blood samples were collected from 67 CH Shandong Province, China. Genomic DNA extracted peripheral blood leucocytes. PCR direct sequencing used analyse all exons TG. Detailed medical records then collected, relationship genotype phenotype caused by investigated.Analysis revealed nine mutations,...
Holographic display has attracted widespread interest because of its ability to show the complete information object and bring people an unprecedented sense presence. The absence ideal recording materials hampered realization their commercial applications. Here we report that response time a bismuth magnesium co-doped lithium niobate (LN:Bi,Mg) crystal is shortened 7.2 ms sensitivity as high 646 cm/J. was used demonstrate real-time holographic with refresh rate 60 Hz, popular high-definition...
The ability to amplify optical signals is of paramount importance in photonic integrated circuits (PICs). Recently, lithium niobate on insulator (LNOI) has attracted increasing interest as an emerging PIC platform. However, the shortage efficient active devices LNOI platform limits development amplification. Here, we report waveguide amplifier based erbium and ytterbium co-doped by using electron beam lithography inductively coupled plasma reactive ion etching process. We have demonstrated...
The UV photorefraction of Zr-doped lithium niobate (LN:Zr) was investigated. experimental results show that LN:Zr crystals have high resistance against in the region as well visible range and can withstand a light intensity above 105 W/cm2. According to fitting erasing curves with green light, two-center O2−/−-defect model suggested. Our indicate is an excellent candidate for optical damage from spectrum.
A series of Zr and Fe codoped LiNbO3 crystals was grown their photorefractive properties have been investigated. Compared with LiNbO3:Fe,Hf, the concentration Fe2+ ions is strongly increased in LiNbO3:Fe,Zr. As a result, response speed these as-grown LiNbO3:Fe,Zr only 2s sensitivity larger than 12cm∕J while saturation diffraction efficiency still remains at high level. These findings prove that an excellent choice for volume holographic storage.
The orphan nuclear receptor small heterodimer partner (SHP) regulates metabolic pathways involved in hepatic bile acid production and both lipid glucose homeostasis via the transcriptional repression of other receptors. In present study, we generated fat-specific SHP-overexpressed transgenic (TG) mice determined potential role SHP activation, specifically adipocytes, regulation adipose tissue function response to stressors. We 2 mo-old TG body weight, fat mass index, tissues morphology,...
With the increasing demand for system integration to cater continuously number of I/Os as well higher operating frequencies, reconfigured wafer-level packaging, or embedded WLP (EMWLP) is emerging a promising technology integration. This platform allows integrated passives be designed in redistribution layers using mold compound substrate, which significantly improves performance compared those on-chip. In this paper, we present low loss on EMWLP demonstrated 5.5-GHz band pass filter...
We have developed a highly sensitive electric-field sensor with novel comb-shaped microelectrodes. The is based on modulating an incident field grounded shutter and measuring the induced charge of sensing electrodes. Owing to covering side wall electrodes, fringing fields are no longer factor that reduces performance sensor. Moreover, in order improve efficiency induction, microelectrodes introduced. can measure not only electrostatic field, but also AC field. Tested ambient air conditions,...
Molybdenum-doped lithium niobate crystals were grown under different polarization conditions and their holographic properties investigated. In contrast to current dopants, hexavalent molybdenum prefers niobium sites. Thereby, storage becomes possible from the ultraviolet visible with considerably lower response time. The time of 0.5 mol. % Mo-doped LiNbO(3) can be especially shortened as small 0.35 s a still high saturation diffraction efficiency about 60% at 351 nm. thus is promising...
Dual-oxidase maturation factor 2 (DUOXA2) is a component of the thyroid hydrogen peroxidase (H2O2) generator, which crucial for hormone synthesis. Genetic defects in DUOXA2 lead to an impairment H2O2-generating system, turn causing congenital hypothyroidism (CH) with goiter.Our study aimed identify mutations associated Chinese goiter patients and examine molecular mechanism underlying genotype-phenotype relationship. All exons flanking sequences 75 unrelated CH were amplified by PCR directly...
Abstract For a long time that optical damage was renamed as photorefraction, here we find the resistance and photorefraction can be simultaneously enhanced in MgO Bi 2 O 3 co-doped LiNbO (LN:Bi,Mg). The photorefractive response of LN:Bi,Mg shortened to 170 ms while sensitivity reached up 21 cm /J. Meanwhile, crystals could withstand light intensity higher than 10 6 W/cm without apparent damage. Our experimental results indicate doesn’t equal underground mechanism analyzed attributed...