Abstract Meningioma, as a sort of the malignantly intracranial tumors, has captured public attention for its second‐highest morbidity all over world. Long noncoding RNAs (lncRNAs), including lncRNA SNHG1, have been well known essential players in development diverse cancers. However, biological effect and regulatory mechanism SNHG1 not mentioned meningioma. In this work, it was discovered that overexpressed meningioma cell lines. deficiency restrained growth accelerated apoptosis. Then...

Lumbar disc herniation is primarily caused by intervertebral degeneration (IVDD). Nucleus pulposus (NP) cell dysfunction leads to pro-inflammatory cytokines secretion increase, causing extracellular matrix (ECM) degradation. ECM essential for maintaining normal function. Glycoprotein (Transmembrane) Nmb (GPNMB) strongly associated with inflammation, and its expression effects in IVDD are unclear. We categorized 40 clinically collected samples using the magnetic resonance imaging (MRI)-based...

In this study, we evaluate whether the use of biliverdin (BV), a natural non-toxic antioxidant product haeme catabolism, can suppress head and neck squamous cell carcinoma (HNSCC) proliferation improve tumour survival both in vitro vivo. Furthermore, investigate therapeutic outcome relies on BV's potent effect reactive oxygen species (ROS)-mediated signalling.Two well-characterised HNSCC lines mouse model with human were used for study. vitro, BV ROS was assayed. Subsequently, critical...

Ethnopharmacological Relevance . Glycyrrhiza inflat Bat. is widely used to treat gastric ulcer and gastritis in clinic China. Aim of the Study To investigate protective effects possible mechanisms total flavonoid extract (TFE) from G. on atrophic (AG) rats. Materials Methods The rat AG model was established by providing sodium deoxycholate alcohol, then, rats were treated with TFE for 30 days. Pathologic changes specimens observed using hematoxylin eosin staining, capability mucosa secrete...

Poly(ADP-ribose) polymerases (PARP) and the Mre11, Rad50, Nbs1 (MRN) complex are key regulators of DNA repair, have been recently shown to independently regulate telomere length. Sensitivity cancers PARPi is largely dependent on BRCAness cells. Unfortunately, vast majority BRCA-proficient. In this study, therefore, we investigated whether a targeted molecular "hit" MRN complex, which upstream BRCA, can effectively sensitize BRCA-proficient head neck squamous cell carcinoma (HNSCC) PARP...

Smilax glabra Roxb (SGR) as a novel anti-tumor agent has been paid attention in several types of cancer cells. However, the effect SGR on SGC7901 cells not investigated.We investigate and potential mechanisms this study.Three kinds gastric cell lines (BGC823, MKN45) one kind human embryonic kidney line (HEK293) were exposed to varying concentrations SRG. Then, we observed SRG these changes proliferation, invasion apoptosis. Finally, detected signaling pathway which may involve.SGR...

This study set out to explore the potential role of microRNA-361-5p (miR-361-5p) in acute pancreatitis through regulation interleukin-17A (IL-17A). We first identified expression miR-361-5p, IL-17A, nuclear factor IA (NFIA), and hes family bHLH transcription 1 (Hes1) serum samples collected from patients with pancreatitis, caerulein-induced mice, a Th17 cell model. The predicted binding miR-361-5p NFIA was confirmed vitro. Gain- loss-of-function assays were employed elucidate their effects...

According to the status of unified enrollment computer specialty for undergraduates in BIT (Beijing Institute Technology) and mode EEEP (Excellent Engineer Education Project) China, we analyze concrete requirements "Output-Oriented" teaching evaluation International Engineering Accreditation, propose a FCTS: Five-in-One Closed-loop Training Scheme, which is key constituent part innovation cultivating engineering technology professionals. This FCTS, as guideline Cultivation Program 2016,...

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A new disposable α-amylase biosensor has been developed based on the encapsulation of both glucose oxidase (GOD) and α-glucosidase in composite film sol-gel/Nafion.1, 1-dimethyl-3-(2-amino-1-hydroxyethyl) ferrocene (DMAHFc) as an electron transferring mediator was immobilized screen-printed electrode surface by Nafion. Under optimal conditions this able to detect activity linear range 15-980 IU L <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Abstract Head and neck cancer patients often present with advanced disease and, despite advances in chemoradiation treatment protocols, continue to have a poor prognosis while experiencing severe induced toxicity. There is an increased demand for natural, non-toxic agents treatment, which can be either used alone or combination our therapies. In this study, we are using biliverdin (BV), antioxidant bile pigment, oxidized from bilirubin. As potent antioxidant, accumulating data observations...

Abstract While platinum-based agents like cisplatin (DDP) are the mainstay of chemotherapeutic options for several tumor types, including ovarian, lung, and head neck squamous cell carcinoma, resistance to these can significantly contribute treatment failure increase need higher toxic doses. Tumors heterogeneous in nature, with their growth sustained by a small subpopulation highly malignant cells, termed cancer stem cells (CSCs). These comprise top hierarchy, remarkably chemoresistant,...

Guided method was used in the Clinical Laboratory Instrument courses to guide students with inquiry-based learning problems,breaking traditionalcrammingteaching,learning and giving full play initiative enthusiasm,stimulateing students'interest optimize teaching process improve quality of teaching. Key words: Guided;  Teaching;  Instrument; Teaching

The article enunciates the importance of studying and exploiting medical virtual laboratory for reforming undergraduate experimental teaching modes, improving qualities by expounding conditions characteristics constructed laboratory, analyzing implementation effectiveness laboratory. Key words: Undergraduate education; Experimental teaching; Virtual

Abstract Background Previous studies have shown that breast cancer and thyroid are more common in females . Among them, the incidence of female research ranks first. Thyroid is most endocrine malignancy women. cuproptosis a new type programmed cell death discovered recently. The objective this study was to evaluate prognostic significance related miRNA (CRM) cancers explore potential associations between two cancers. Methods： We extracted transcriptomic data clinicopathological features...

Abstract Introduction Head and neck cancer (HNC) is notoriously difficult to treat the five-year survival rate has improved very little over past thirty years. squamous cell carcinomas (HNSCC) mouse models are invaluable tools for furthering mechanistic HNC research. Molecular imaging (MI) a promising new modality that may improve current models. Visible florescent proteins (VFPs) have been widely used with animal tumor detection using MI. However, low emission wavelength of VFP results in...