A5013819031- Endoplasmic Reticulum Stress and Disease
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Phytochemistry and Bioactivity Studies
- Essential Oils and Antimicrobial Activity
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- RNA regulation and disease
Fundación Ciencia and Vida
2025
University of Chile
2019
Center for Climate and Resilience Research
2019
Under conditions of amino acid deficiency, mammalian cells activate a nutrient-sensing kinase known as general control nonderepressible 2 (GCN2). The activation GCN2 results in the phosphorylation alpha subunit eukaryotic initiation factor (eIF2α), which can be phosphorylated by three other integrated stress response (ISR) kinases, reducing overall protein synthesis. also promotes translation specific mRNAs, some encode transcription factors that enhance genes involved synthesis, transport,...