A5084682688- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Nerve injury and regeneration
- RNA regulation and disease
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Viral Infections and Immunology Research
- Cell death mechanisms and regulation
- Cancer Treatment and Pharmacology
- Alzheimer's disease research and treatments
- Trace Elements in Health
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Signaling Pathways in Disease
- Chemotherapy-related skin toxicity
- Sirtuins and Resveratrol in Medicine
Fundación Ciencia and Vida
2021-2025
San Sebastián University
2021-2025
University of Chile
2021
Center for Climate and Resilience Research
2021
Pontificia Universidad Católica de Chile
2011-2020
Universidad Mayor
2019-2020
Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative can cause permanent loss of function, so it represents a focus for neuroprotective strategies. Several signaling pathways are implicated in axonal degeneration, but identification integrative mechanism this self-destructive remained elusive. Here, we show rapid distinct mechanical...
Axonal degeneration represents an early pathological event in neurodegeneration, constituting important target for neuroprotection. Regardless of the initial injury, which could be toxic, mechanical, metabolic, or genetic, axons shares a common mechanism involving mitochondrial dysfunction and production reactive oxygen species. Critical steps this degenerative process are still unknown. Here we show that calcium release from axonal endoplasmic reticulum (ER) through ryanodine IP3 channels...
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated axonal but researchers so far unable identify integrative signaling pathway activating this self-destructive process. Through pharmacological genetic approaches, we tested whether necroptosis, a regulated cell-death mechanism pathogenesis neurodegenerative diseases,...
Under conditions of amino acid deficiency, mammalian cells activate a nutrient-sensing kinase known as general control nonderepressible 2 (GCN2). The activation GCN2 results in the phosphorylation alpha subunit eukaryotic initiation factor (eIF2α), which can be phosphorylated by three other integrated stress response (ISR) kinases, reducing overall protein synthesis. also promotes translation specific mRNAs, some encode transcription factors that enhance genes involved synthesis, transport,...
Abstract Although there are several pathways to ensure that proteins folded properly in the cell, little is known about molecular mechanisms regulating histone folding and proteostasis. In this work, we identified chaperone-mediated autophagy (CMA) main pathway involved degradation of newly synthesized histones H3 H4. This finely regulated by interplay between HSC70 tNASP, two interacting proteins. tNASP stabilizes levels blocking direct transport into lysosomes. We further demonstrate CMA...
Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces disabling form neuropathy resulting more than 60% patients having reduce or discontinue oxaliplatin, negatively impacting their chance survival. Oxaliplatin-induced neuropathies are accompanied degeneration sensory fibers epidermis and hyperexcitability neurons. These morphological functional changes have been associated with symptoms such...
Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal synaptic degeneration are early critical elements nearly all human neurodegenerative diseases neural injury, however molecular mechanisms which regulate this process yet be fully elucidated. Furthermore, how governing impacted by age individual is poorly understood. Interestingly, in mice under 3 weeks age, axons synapses following hypoxic or...