A5085695620- Microbial Community Ecology and Physiology
- Marine and coastal ecosystems
- Protist diversity and phylogeny
- Bacteriophages and microbial interactions
- Soybean genetics and cultivation
- Marine Biology and Ecology Research
- Algal biology and biofuel production
- Evolution and Genetic Dynamics
- Graphene and Nanomaterials Applications
- Marine Biology and Environmental Chemistry
- Ocean Acidification Effects and Responses
- RNA Interference and Gene Delivery
- Wastewater Treatment and Nitrogen Removal
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
Weizmann Institute of Science
2014-2025
Pancreatic ductal adenocarcinoma (PDA) represents an unmet therapeutic challenge. PDA is addicted to the activity of mutated KRAS oncogene which considered so far undruggable target. We propose approach target effectively in patients using RNA interference. To meet this challenge, we have developed a local prolonged siRNA delivery system (Local Drug EluteR, LODER) shedding against (siG12D LODER). The siG12D LODER was assessed for its structural, release, and properties vitro vivo. effect on...
Aquatic photosynthetic eukaryotes represent highly diverse groups (green, red, and chromalveolate algae) derived from multiple endosymbiosis events, covering a wide spectrum of the tree life. They are responsible for about 50% global photosynthesis serve as foundation oceanic fresh water food webs. Although ecophysiology molecular ecology some algal species extensively studied, basic aspects cell biology still underexplored. The recent wealth genomic resources algae has opened new frontiers...
Nutrient availability is an important factor controlling phytoplankton productivity. Phytoplankton contribute c. 50% of the global photosynthesis and possess efficient acclimation mechanisms to cope with nutrient stress. We investigate cellular response bloom-forming coccolithophore Emiliania huxleyi phosphorus (P) scarcity, which often a limiting in marine ecosystems. combined mass spectrometry, fluorescence microscopy, transmission electron microscopy (TEM) gene expression analyses order...
Summary Marine photosynthetic microorganisms are the basis of marine food webs and responsible for nearly 50% global primary production. E miliania huxleyi forms massive oceanic blooms that routinely terminated by large double‐stranded DNA coccolithoviruses. The cellular mechanisms govern replication cycle these giant viruses largely unknown. We used diverse techniques, including fluorescence microscopy, transmission electron cryoelectron tomography, immunolabeling biochemical methodologies...
Recognizing the life cycle of an organism is key to understanding its biology and ecological impact. Emiliania huxleyi a cosmopolitan marine microalga, which displays poorly understood biphasic sexual comprised calcified diploid phase morphologically distinct biflagellate haploid phase. Diploid cells (2N) form large-scale blooms in oceans, are routinely terminated by specific lytic viruses (EhV). In contrast, (1N) resistant EhV. Further evidence indicates that 1N may be produced during viral...
Abstract Algal blooms drive global biogeochemical cycles of key nutrients and serve as hotspots for biological interactions in the ocean. The massive cosmopolitan coccolithophore Emiliania huxleyi are often infected by lytic E. virus, which is a major mortality agent triggering bloom demise. This multi-annual “boom bust” pattern suggests that coexistence essential these host–virus dynamics. To investigate coexistence, we developed new model system from an culture recovered viral infection....
Phytoplankton produce the volatile dimethyl sulfide (DMS), an important infochemical mediating microbial interactions, which is also emitted to atmosphere and affecting global climate. Albeit enzymatic source for DMS in eukaryotes was elucidated, namely a DMSP lyase (DL) called Alma1, we still lack basic knowledge regarding its taxonomic distribution. We defined unique sequence motifs enable identification of DL homologs (DLHs) model systems environmental populations. used these predict DLHs...
Abstract Phytoplankton produce the volatile dimethyl sulfide (DMS), an important infochemical, which is emitted to atmosphere and affecting global climate. Albeit enzymatic source for DMS in eukaryotes was elucidated, namely a DMSP lyase (DL) called Alma1, we still lack basic knowledge regarding its taxonomy biogeographic distribution. We defined unique sequence motifs enable identification of DL homologs (DLHs) model systems environmental populations. used these predict DLHs diverse algae...
Abstract Phytoplankton are key components of the oceanic carbon and sulfur cycles 1. During bloom events, some species can emit massive amounts organosulfur volatile dimethyl sulfide (DMS) to atmosphere, where it modulate aerosol formation affect climate. In aquatic environments, DMS plays an important role as a chemical signal mediating diverse trophic-level interactions. Yet its in microbial predator-prey interactions remains elusive with contradicting evidence for algal defense grazer’s...
Abstract Algal blooms drive global biogeochemical cycles of key nutrients in the oceans and serve as hotspots for biological interactions. The massive spring cosmopolitan coccolithophore Emiliania huxleyi (E. huxleyi) are often infected by lytic specific virus (EhV) which is a major mortality agent triggering bloom demise. Nonetheless, multi-annual “boom bust” pattern E. suggests that mechanisms coexistence essential these host-virus dynamics. To investigate coexistence, we developed new...