Jeffrey A. McGuire

ORCID: 0000-0002-5847-7018
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Pelvic floor disorders treatments
  • Pelvic and Acetabular Injuries
  • Pregnancy-related medical research
  • Anorectal Disease Treatments and Outcomes
  • Mechanical Behavior of Composites
  • Ultrasonics and Acoustic Wave Propagation
  • Optical measurement and interference techniques
  • Hemodynamic Monitoring and Therapy
  • Engineering Structural Analysis Methods
  • Fatigue and fracture mechanics
  • Optical Imaging and Spectroscopy Techniques
  • Urinary Tract Infections Management
  • Urological Disorders and Treatments
  • Advanced Mathematical Modeling in Engineering
  • Elasticity and Material Modeling
  • Cell Image Analysis Techniques
  • Educational Robotics and Engineering
  • Numerical methods in engineering
  • Central Venous Catheters and Hemodialysis
  • Cellular Mechanics and Interactions

Virginia Tech
2015-2023

Around 80% of women experience vaginal tears during labour when the diameter vagina must increase to allow passage a full-term baby. Current techniques for evaluating are qualitative and often lead an incorrect diagnosis inadequate treatment, severely compromising quality life women. In order characterize failure properties tissue, whole tracts from rats (n = 18) were subjected free-extension inflation tests until rupture using custom-built experimental set-up. The resulting deformations...

10.1098/rsfs.2019.0029 article EN Interface Focus 2019-06-14

Vaginal tears are very common and can lead to severe complications such as hemorrhaging, fecal incontinence, urinary dyspareunia. Despite the implications of vaginal on women's health, there currently no experimental studies tear behavior tissue. In this study, planar equi-biaxial tests square specimens tissue, with sides oriented along longitudinal direction (LD) circumferential (CD), were conducted using swine animal model. Three groups mechanically tested: NT group (n = 9), which had...

10.1115/1.4042437 article EN Journal of Biomechanical Engineering 2019-01-09

The vagina undergoes large finite deformations and has complex geometry microstructure, resulting in material geometric nonlinearities, complicated boundary conditions, nonhomogeneities within element (FE) simulations. These nonlinearities pose a significant challenge for numerical solvers, increasing the computational time by several orders of magnitude. Simplifying assumptions can reduce significantly, but this usually comes at expense simulation accuracy. This study proposed use reduced...

10.1002/cnm.3660 article EN publisher-specific-oa International Journal for Numerical Methods in Biomedical Engineering 2022-11-05

The vagina is a viscoelastic fibromuscular organ that provides support to the pelvic organs. properties of are understudied but may be critical for stability. Most studies evaluate vaginal viscoelasticity under single uniaxial load; however, subjected dynamic multiaxial loading in body. It unknown how varied conditions affect behavior and which microstructural processes dictate response. Therefore, objective was develop methods using extension-inflation protocols quantify creep various...

10.1115/1.4052365 article EN Journal of Biomechanical Engineering 2021-09-08

Significance: The spatial organization of collagen fibers has been used as a biomarker for assessing injury and disease progression. However, quantifying this complex structures is challenging. Aim: To quantify classify fiber organizations. Approach: Using quantitative second-harmonic generation (SHG) microscopy, we show that collagen-fiber orientation can be viewed pseudovector fields. Subsequently, analyze them using fluid mechanic metrics, such energy U, enstrophy E, tortuosity τ....

10.1117/1.jbo.27.1.016503 article EN cc-by Journal of Biomedical Optics 2022-01-31
Coming Soon ...