A5006270684- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Central Venous Catheters and Hemodialysis
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- Microplastics and Plastic Pollution
- Composite Material Mechanics
- Advanced Cellulose Research Studies
- Nanoparticle-Based Drug Delivery
- Epoxy Resin Curing Processes
- Dental Implant Techniques and Outcomes
- Innovations in Concrete and Construction Materials
- Drug Solubulity and Delivery Systems
- COVID-19 and healthcare impacts
- Optical Imaging and Spectroscopy Techniques
- Nanocomposite Films for Food Packaging
- Advanced Energy Technologies and Civil Engineering Innovations
- Advanced Drug Delivery Systems
- Antimicrobial agents and applications
- Recycled Aggregate Concrete Performance
- Diversity and Career in Medicine
Virginia Tech
2015-2025
Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences
2014-2015
Wake Forest University
2014
Although bone-patellar tendon-bone (B-PT-B) autografts are the gold standard for repair of anterior cruciate ligament ruptures, they suffer from drawbacks such as donor site morbidity and limited supply. Engineered tissues modeled after B-PT-B promising alternatives because have potential to regenerate connective tissue facilitate osseointegration. Towards long-term goal regenerating ligaments their bony insertions, objective this study was construct 2D meshes 3D cylindrical composite...
Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the differential effects of age on early outcome remain understudied. Using a male murine model moderate contusion injury, we investigated underlying mechanism(s) regulating distinct response between juvenile and adult TBI. We demonstrate similar biomechanical physical properties naive brains. However, following controlled cortical impact (CCI), mice displayed reduced lesion formation, cell death,...
Abstract 3D in vitro organotypic bone models enable the study of human cells an environment that mimics vivo physiology and mechanobiology. However, creating large tissue scaffolds (≈1 cm 3 ) with fine feature sizes (≈200–400 µm) interconnected porosity is not feasible at scale using traditional stochastic techniques. Thus, this aimed to manufacture porous scaffold geometries a novel, osteoconductive resin via vat photopolymerization analyze their ability mimic micromechanical environment....
3D-printed bone scaffolds hold great promise for the individualized treatment of critical-size defects. Among resorbable polymers available use as 3D-printable scaffold materials, poly(ε-caprolactone) (PCL) has many benefits. However, its relatively low stiffness and lack bioactivity limit in load-bearing scaffolds. This study tests hypothesis that surface-oxidized cellulose nanocrystals (SO-CNCs), decorated with carboxyl groups, can act multi-functional additives (1) improve mechanical...
One weakness with currently researched skeletal muscle tissue replacement is the lack of contraction and relaxation during regenerative process. A biocompatible scaffold that can act similar to would be a pivotal innovation. Coaxial electrospun scaffolds, capable movement electrical stimulation, were created using poly(ɛ-caprolactone) (PCL), multiwalled carbon nanotubes (MWCNT), (83/17 or 40/60) poly(acrylic acid)/poly(vinyl alcohol) (PAA/PVA) hydrogel. The two scaffolds implanted into...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Kevin Ortman, Donald Baird, Peter Wapperom, Abby Whittington; Using startup of steady shear flow in a sliding plate rheometer to determine material parameters for the purpose predicting long fiber orientation. J. Rheol. 1 July 2012; 56 (4): 955–981. https://doi.org/10.1122/1.4717496 Download citation file: Ris...
Water-soluble polymers as sacrificial supports for additive manufacturing (AM) facilitate complex features in printed objects. Few water-soluble beyond poly(vinyl alcohol) enable material extrusion AM. In this work, charged poly(ether ester)s with tailored rheological and mechanical properties serve novel materials extrusion-based AM at low temperatures. Melt transesterification of poly(ethylene glycol) (PEG, 8k) dimethyl 5-sulfoisophthalate afforded sufficient molecular weight to impart...
Urinary catheters often become contaminated with biofilms, resulting in catheter-associated urinary tract infections (CAUTIs) that adversely affect patient outcomes.Histotripsy is a noninvasive focused ultrasound therapy previously developed for the ablation of cancerous tumors and soft tissues.Histotripsy has also shown ability to treat biofilms on glass slides surgical meshes.Here, we investigate potential histotripsy treatment CAUTIs first time vitro.Clinically relevant catheter materials...
Abstract The method of ellipses (MoE) is a common experimental technique utilized to quantitatively determine the orientation state population rigid fibers within fiber–polymer composite. In this research, validity applying MoE long, semi‐flexible fiber systems in which majority are flexible discussed. components tensor were first determined for composite formed by homogenous, simple shear field. minimum acceptable image analysis width, or bin selected geometry was found be ∼5.5 mm, 1.4...
During urethral catheterization, sliding friction can cause discomfort and even hemorrhaging. In this report, we use a lubricant-impregnated polydimethylsiloxane coating to reduce the of catheter. Using pig urethra attached microforce testing system, found that catheter reduces during insertion by more than factor two. This suggests slippery, surfaces have potential enhance patient comfort safety catheterization.
Due to the occurrence of plastic impaction in ruminants and its deleterious effects on health production, it is necessary determine suitability biodegradable polymers replace polyethylene-based agricultural plastics, such as hay netting. The objectives this study were evaluate clearance a polyhydroxyalkanoate (PHA) poly(butylene succinate-co-adipate) (PBSA) melt-blend polymer from rumen when fed cattle subsequent animal health. Twelve Holstein bull calves dosed with an encapsulated 13.6 g...
Higher gelatin molecular weight distributions produce larger nanoparticle diameters, which is independent of type.
Polyurethanes (PUs) are commonly used materials for medical devices. These devices exposed repeatedly to radiation when patients undergo radiotherapy treatments. It has been found that peripherally inserted central catheters (PICCs) and venous (CVCs) fail at an increased rate (14.7% 8.8%, respectively) radiated. Currently, little research is available on failure seen in conjunction with radiation, but complex vivo environments within a human patient make it difficult isolate effects of...