A5100410318- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Medical Imaging Techniques and Applications
- T-cell and B-cell Immunology
- Advanced X-ray and CT Imaging
- Liver Diseases and Immunity
- Sarcoidosis and Beryllium Toxicity Research
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Liver physiology and pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Digital Radiography and Breast Imaging
Guilin Medical University
2021-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2013
Zhongda Hospital Southeast University
2012
An excessive accumulation of extracellular matrix composed by insoluble collagen is the core pathogenic change fibroproliferative diseases including pulmonary fibrosis. We recently found that autophagy, a self-catabolic process maintains intracellular homeostasis, participates critically in regulation degradation fibrotic tissues. Here we report treatment mice with SB216763, potent and selective inhibitor glycogen synthase kinase-3 (GSK3), significantly decreased bleomycin (BLM)-induced...
Epithelial-mesenchymal transition (EMT) is a key cellular event in the early stage of tubulointerstitial fibrosis (TIF). Monocyte infiltration plays an important role progression TIF. We have previously demonstrated that monocytes can directly induce HK-2 cell by direct contact. Dexamethasone, anti-inflammatory and immunosuppressant agent, has been widely used renal disease for decades. Whether it could influence monocyte interaction prevent EMT still uncertain. In this study, we found...
In this study, we aimed to investigate Bregs, their regulatory effects on Th17/Treg cell balance, and the release of downstream inflammatory factors in a mouse model low-density lipoprotein receptor (LDLr)-/- + Pristane.After establishment systemic lupus erythematosus (SLE) complicated with atherosclerosis (AS), 8-week-old LDLr-/- Pristane mice (n = 10) were included SLE AS group. Furthermore, MRL/lpr C57 used as normal control groups, respectively 10 per group). After feeding high-fat diet...