A5022373401- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Plant biochemistry and biosynthesis
- Bioinformatics and Genomic Networks
- Metabolomics and Mass Spectrometry Studies
- Chemical synthesis and alkaloids
- Computational Drug Discovery Methods
- Phytochemical Studies and Bioactivities
- Fungal Biology and Applications
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Alkaloids: synthesis and pharmacology
Helmholtz Centre for Infection Research
2021-2024
Technische Universität Braunschweig
2021-2024
German Center for Infection Research
2024
Triangularia mangenotti was analyzed for the production of secondary metabolites, resulting in isolation known zopfinol (1) and its new derivatives B–C (2–4), 10-membered lactones 7-O-acetylmultiplolide A (5) 8-O-acetylmultiplolide (6), together with sordarin (7), B (8), hypoxysordarin (9). The absolute configuration 1 elucidated by synthesis MPTA-esters. Compound showed antimicrobial activity against Gram-positive bacteria Bacillus subtilis Staphylococcus aureus fungus Mucor hiemalis. While...
Moringadepsin (
is a model mushroom belonging to the fungal phylum Basidiomycota. Among others,
The new genus Morinagamyces is introduced herein to accommodate the fungus Apiosordaria vermicularis as inferred from a phylogenetic study based on sequences of internal transcribed spacer region (ITS), nuclear rDNA large subunit (LSU), and partial fragments ribosomal polymerase II 2 (rpb2) β-tubulin (tub2) genes. was analyzed for production secondary metabolites, resulting in isolation depsipeptide named morinagadepsin (1), already known chaetone B (3). While planar structure 1 elucidated...
Metabolites
Streptogramins are the last line of defense antimicrobials with pristinamycin as a representative substance used therapeutics against highly resistant pathogenic bacteria. However, emergence (multi)drug-resistant pathogens renders these valuable antibiotics useless; making it necessary to derivatize compounds for new compound characteristics, which is often difficult by chemical de novo synthesis due complex nature molecules. An alternative derivatization mutasynthesis. Herein, we report...