A5101968414- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Dental Implant Techniques and Outcomes
- Gut microbiota and health
- Cervical Cancer and HPV Research
- Oral Health Pathology and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Icing and De-icing Technologies
- Reproductive System and Pregnancy
- Cryospheric studies and observations
- Arsenic contamination and mitigation
- Preterm Birth and Chorioamnionitis
- Heavy metals in environment
- Air Quality Monitoring and Forecasting
- Dental Radiography and Imaging
- Fluoride Effects and Removal
- Viral-associated cancers and disorders
- Orthodontics and Dentofacial Orthopedics
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
Kunming Medical University
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2023
Huzhou University
2005-2022
Sir Run Run Shaw Hospital
2019-2021
Zhejiang University
2019-2021
Lanzhou University
2017
The Military General Hospital of Beijing PLA
2016
Fujian Medical University
2009-2012
Zhangzhou Municipal Hospital of Fujian Province
2009-2012
Abstract Objectives Colorectal cancer (CRC) is the fourth most commonly diagnosed worldwide. Solanine a phytochemical extracted from traditional Chinese medicine with widely reported anticancer effects. Here, we investigated potential role of solanine in regulating ferroptosis CRC cells and scrutinized molecular mechanism. Methods Cell growth cytotoxicity were examined using CCK-8 proliferation assay lactate dehydrogenase assay. Oxidative stress was determined by measuring glutathione (GSH),...
Ovarian cancer is the leading cause of death in gynecologic malignancies. Growing evidences demonstrate that a complicated relationship exists between gut microbiota and treatment. However, there are few studies explored alterations ovarian patients following anti-cancer treatments. Therefore, we aim to analyze changes treated with radical surgery chemotherapy.The microbial genes were examined from total 75 fecal samples 18 patients, including 10 preoperative (Group B), 4 postoperative M0),...
Objective We explored the gut microbiome and serum metabolome alterations in patients with premature ovarian insufficiency (POI) effects of hormone replacement therapy (HRT) aim to unravel pathological mechanism underlying POI. Methods Fecal samples obtained from healthy females (HC, n = 10) POI treated (n or without HRT were analyzed using 16S rRNA gene sequencing untargeted metabolomics analysis, respectively. Peripheral blood collected detect cytokine levels. Spearman’s rank correlation...
Introduction: This study aimed to investigate the role of lncRNA MCM3AP-AS1 in colorectal cancer (CRC). Methods: Paired tumor and non-tumor tissues were collected from 60 CRC patients. Expression was determined by RT-qPCR. Overexpression MCM3AP-AS1, miR-545, CDK4 cells achieved explore interactions between them. Cell cycle assay performed analyze roles regulating cell progression cells. Results: We found that upregulated its high expression levels predicted poor survival is interact with...
Background. Gastric cancer (GC) is a common malignancy that can be formed by methylation-induced deactivation of tumor silencer genes, which one the key mechanisms tumorigenesis. SEPT9 methylation, symptomatic marker for tumors, downregulate gene expression. Long noncoding RNA small nucleolar host 3 (lncRNA SNHG3) new type lncRNA related to cancer. Our study investigated mechanism SNHG3 regulation methylation and its effects on growth, metastasis, spread gastric cells. Methods. Quantitative...
Abstract To evaluate the change of cervical length and best timing for pregnancy after conization in patients with intraepithelial neoplasia (CIN). This was a retrospective study including under 40 years fertility desire treated by CIN. assess length, were divided into 2 groups according to different surgery procedure: loop electrosurgical excision procedure (LEEP) cold knife conisation (CKC). Patients < 2.5 cm CKC group whether receiving cerclage. Trans-vaginal ultrasound examination...
The ice accretion on the aircraft's surface under low temperatures and high humidity is crucial for flight safety. With respect to limitation of traditional icing simulation methods, it very hard predict exact profiles, which can extremely affect performance an aircraft. A conditional generative adversarial network (CGAN) utilized rapidly reconstruct three-dimensional patterns along leading edge a wing. CGAN trained using experimental data obtained from wing with varying sweep angles....
Objective To investigate the value of serum MIR4435-2HG level in diagnosis and prognosis oral squamous cell carcinoma. Methods This study was a retrospective case-control study. Five hundred eighteen samples carcinoma patients with head neck cancer genome atlas project (TCGA) database, long noncoding RNA expression. The median boundary, were divided into high expression group low group, 5-year disease-free survival rate overall two groups compared. Serum from 82 who admitted to...
Background: There is still a lack of credible evidence in the literature regarding effectiveness recombinant human bone morphogenetic protein 2 (rhBMP-2) regeneration alveolar defects. Therefore, purpose this study to evaluate efficacy and safety rhBMP-2 autogenous graft defects provide basis for clinical practice. Methods: As March 2023, two independent investigators will identify target by searching seven major databases (EMBASE, Google Scholar, PubMed, Cochrane Library, Wan Fang, CNKI,...
Objective:Nasopharyngeal carcinoma(NPC) is a common malignant tumor, in recent years,most of studies have found that micro RNA played an important role the development NPC.This study was to explore expression level MiR-148a and its effect on biological functions NPC cells.Method:The cell line CNE2 detected by Real-time PCR method.MTT,clone formation assay flow cytometry were applied detect proliferation apoptosis. We predicted EGFR downstream target genes through analysis bioinformatics...
Objective To investigate the expression of histone acetylated H3 and H4, methylated H3K4 H3K9 in diffuse large B-cell lymphoma (DLBCL). Methods The were examined by SP immunohistochemistry technique lymphoid tissue 40 cases with DLBCL 16 proliferative lymphadenitis. Results acetylation H4 lower than that Histone was higher expression. There a positive correlative between global H3, methylation H3K4. Conclusion Improper modification acetylations methylations may play an important role...
Nonsyndromic cleft lip with or without palate (nsCL/P)accounts for the majority of orofacial clefting in humans.New insights into etiology nsCL/P are requiring diversified and complementary investigative technologies.Since proteins act as functional end products gene expression, this investigation examined some distinct protein expression profiles genes related to by analyzing differentially optimized peripheral serum mass spectrum peak values, utilizing Enhanced Laser Desorption Ionization...
Arsenic (As) is widely concerned due to its serious harmfulness ecological environment and human health. Soils from karst regions are characterized by high geochemical background of As. However, the bioavailability paddy soil As whether there transfer risk Aa form rice still unclear. In this study, 305 paired soil–rice samples were collected in Guangxi, China, study controlling factors system. It was found that concentrations region significantly higher than those non-karst region, while...