A5068664375- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Acute Myeloid Leukemia Research
- Gut microbiota and health
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cervical Cancer and HPV Research
- Intestinal and Peritoneal Adhesions
- Muscle and Compartmental Disorders
- Clostridium difficile and Clostridium perfringens research
- Pharmacological Effects and Toxicity Studies
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Amoebic Infections and Treatments
- Iron Metabolism and Disorders
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Blood disorders and treatments
- Reproductive System and Pregnancy
- DNA Repair Mechanisms
Sir Run Run Shaw Hospital
2019-2024
Zhejiang University
2019-2024
Zhejiang Chinese Medical University
2024
CM Hospital
2024
Hangzhou First People's Hospital
2020
Second Affiliated Hospital of Zhejiang University
2007
Stanford University
2005
Background: The Wilms' tumor suppressor WT1 is reported to work in a range of physiological processes at both transcriptional and posttranscriptional level. WT1-associating protein (WTAP), nuclear co-localized with splicing factors, also plays vital role cellular function cancer progression. However, little known about the WTAP ovarian underlying mechanism. Materials methods: To evaluate expression WTAP, multiple means were applied clinical tissues, including immunohistochemistry,...
Ovarian cancer is the leading cause of death in gynecologic malignancies. Growing evidences demonstrate that a complicated relationship exists between gut microbiota and treatment. However, there are few studies explored alterations ovarian patients following anti-cancer treatments. Therefore, we aim to analyze changes treated with radical surgery chemotherapy.The microbial genes were examined from total 75 fecal samples 18 patients, including 10 preoperative (Group B), 4 postoperative M0),...
Objective We explored the gut microbiome and serum metabolome alterations in patients with premature ovarian insufficiency (POI) effects of hormone replacement therapy (HRT) aim to unravel pathological mechanism underlying POI. Methods Fecal samples obtained from healthy females (HC, n = 10) POI treated (n or without HRT were analyzed using 16S rRNA gene sequencing untargeted metabolomics analysis, respectively. Peripheral blood collected detect cytokine levels. Spearman’s rank correlation...
The fibrinolytic characteristics and clinical pathological significance of pleural ascitic fluid were studied in patients with malignant tumour, tuberculosis or liver cirrhosis. Urokinase plasminogen activator (uPA) urokinase plaminogen receptor (uPAR) levels measured by enzyme-linked immunoadsorbent assay tissue (tPA), inhibitor-1 (PAI-1), (Plg), plasmin (Pl) alpha(2) inhibitor (alpha(2)PI) colorimetric assay. uPA uPAR higher tumour compared cirrhosis, whereas tPA significantly cirrhosis...
Abstract To evaluate the change of cervical length and best timing for pregnancy after conization in patients with intraepithelial neoplasia (CIN). This was a retrospective study including under 40 years fertility desire treated by CIN. assess length, were divided into 2 groups according to different surgery procedure: loop electrosurgical excision procedure (LEEP) cold knife conisation (CKC). Patients < 2.5 cm CKC group whether receiving cerclage. Trans-vaginal ultrasound examination...
To campare the effect and tolerance beween intensified myeloablative conditioning regime (IMCR) without antithymocyte globulin (ATG) (MCR) for single-unit unrelated umbilical cord blood transplantation (sUCBT) in hematological malignancies.The clinical data of 190 patients with malignancies undergoing sUCBT between April 2000 December 2013 at Department Hematology, Anhui Provincial Hospital were retrospectively analyzed, whom 156 received IMCR ATG (IMCR group), including 79 patient receiving...
Abstract Background: The association between marital status and gallbladder cancer (GBC) remains uncertain. This study aimed to verify the relationship GBC construct a prognostic nomogram predict impact of on patients. Method: patients were split into married unmarried groups added Surveillance, Epidemiology, End Results (SEER) database. We employed competing risk analyses, propensity score matching (PSM), Kaplan-Meier survival analyses. After that, was verified predicted constructed....
The association between marital status and gallbladder cancer (GBC) remains uncertain. This study aimed to verify the relationship GBC construct a prognostic nomogram predict impact of on patients. patients were divided into married unmarried groups using data from Surveillance, Epidemiology, End Results (SEER) database. We employed competing risk analyses, propensity score matching (PSM), Kaplan-Meier survival analyses. was then verified, predicted constructed. A total 3913 obtained SEER...
Objective: To compare the efficacy of unrelated cord blood transplantation (UCBT) and HLA-identical sibling peripheral stem cell (PBSCT) for treatment adult hematological malignancies. Methods: From April 2011 to December 2015, a total 81 patients receiving single-unit UCBT 57 PBSCT were enrolled in this study. All received myelablative conditioning. Cyclosporine combined with mycophenolate mofetil was adopted GVHD prophylaxis. Results: The cumulative incidence neutropil engraftment at...
It is widely accepted that there a strong relationship between iron levels and cancer. This study aimed to investigate the serum ferritin severity prognosis of gynecological malignant tumors.
Objective: To explore the clinical efficacy and safety of unrelated umbilical cord blood transplantation (UCBT) in treatment refractory relapsed acute leukemia (AL) patients. Methods: The data 22 AL patients who were treated with UCBT as salvage therapy from November 2009 to May 2017 retrospectively analyzed. All received a myeloablative conditioning regimen for prevention graft-versus-host disease (GVHD) cyclosporine A (CSA)/short course mycophenolate mofetil (MMF). Results: ①Of patients, 9...