A5047035034- Multiple Sclerosis Research Studies
- Autoimmune Neurological Disorders and Treatments
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- IgG4-Related and Inflammatory Diseases
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- Bacterial Infections and Vaccines
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Lung Cancer Research Studies
- SARS-CoV-2 and COVID-19 Research
- Acute Lymphoblastic Leukemia research
- Sarcoidosis and Beryllium Toxicity Research
- Epilepsy research and treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cervical Cancer and HPV Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Social Media in Health Education
- Gallbladder and Bile Duct Disorders
- Spinal Hematomas and Complications
- Lymphadenopathy Diagnosis and Analysis
- Sex and Gender in Healthcare
Monash University
2020-2025
Alfred Health
2019-2025
Barwon Health
2014-2025
Monash Alfred Psychiatry Research centre
2024
The Alfred Hospital
2023-2024
Geelong Hospital
2014-2022
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system. There were 33 335 people with MS in Australia 2021 2917 New Zealand 2006 prevalence incidence are increasing time. Although new treatments have substantially improved outcomes recent decades, treatment landscape has become increasingly complex due to expanding number disease-modifying therapies (DMTs) associated safety considerations. A total 80 consensus recommendations...
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for management MS in Australia New Zealand. Part 1 these guidelines includes related selection initial disease-modifying therapy (DMT) MS, assessments before commencing DMT, monitoring activity on switching discontinuing DMT. This article, 2,...
Objective To examine the utility of peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte (MLR) as biomarkers prognosis in seropositive autoimmune encephalitis (AE). Methods In this multicenter study, we retrospectively analyzed 57 cases AE with hospital admissions between January 2008 June 2019. The initial full examination was used to determine each patients’ NLR MLR. modified Rankin Scale (mRS) utilized assess follow-up disability at 12 months then final...
Ocrelizumab is an anti-CD20 monoclonal antibody (mAb) that has been shown in phase 3 clinical trials to reduce relapses and disease progression multiple sclerosis (MS) patients. Prior the approval of ocrelizumab, rituximab, a chimeric mAb was used treat MS. Rituximab still MS many countries outside Australia remains mainstay treatment non-MS neuroimmunological systemic inflammatory diseases. currently neuromyelitis optica spectrum disorder (NMOSD) autoimmune encephalitis, addition its...
Background In Australia, tixagevimab/cilgavimab 150 mg/150 mg was a government-funded pre-exposure prophylaxis for COVID-19 people with multiple sclerosis (pwMS) and other neuroimmunological conditions (pwNIc) treated anti-CD20 antibodies or sphingosine-1-phosphate receptor modulators were eligible. Objective To analyse the roll-out, uptake real-world efficacy of in prevention severity COVID-19. assess compliance depending on location delivery. Methods We undertook single-centre study. 440...
Epidural blood patching (EBP) is an important therapeutic approach in managing spontaneous cerebrospinal fluid leaks. The mechanism of action likely to be twofold; replacement having immediate tamponade effect and the proximal flow products a ‘plug’ effect. negative pressure gradient within epidural space may rostral injected possibly increased intracranial hypotension.
People with multiple sclerosis and neuroimmunologic disorders (herein referred to as patients) are increasingly treated infusible monoclonal antibodies. This rise in demand has placed increased loads on current infusion services mandates careful strategic planning. study examined patient preferences for the timing location of infusions their association demographic disease variables facilitate patient-focused planning.Ninety-one patients receiving an therapy at service during March 2019 were...
A 74-year-old man presented with a subacute severe thoracic polyradiculopathy affecting the T4–T8 dermatomes bilaterally. Extensive investigation demonstrated markedly raised triglyceride levels of 44 mmol/L (<1.7). The patient's unique presentation is discussed alongside review triglyceride-induced neurotoxicity and therapeutic management.
Introduction Long-term exposure of women with Multiple sclerosis (MS, wwMS) to immunomodulatory or immunosuppressive treatments may increase the risk cervical dysplasia. However, little is known about dysplasia and Human Papillomavirus (HPV)-vaccine coverage in wwMS. Methods Adult wwMS were recruited from two tertiary MS clinics. To explore association between (DMTs) abnormal screening tests (CSTs), we linked individual data MSBase, Victorian Cervical Screening Registry, National HPV...
<h3></h3> Autoimmune encephalitis (AE) encompasses a number of neuroinflammatory conditions. Optimal biomarkers to guide therapeutic decision making and prognostication remain be identified. <h3>Objective</h3> To identify disease severity predictors patient outcome. <h3>Methods</h3> Clinical, radiological, serological, CSF, EEG neuropsychological data in patients with AE are being collected from (12 sites) around Australia. Samples on 6-monthly basis for 3.5 years the prospective arm...
Introduction: Leptomeningeal rheumatoid nodules are a rare condition. This case demonstrates the unique presentation and diagnostic workup for distinctive condition highlights difficulties surrounding therapeutics. Case Presentation: A 67 year old woman presented with recurrent transient ischaemic attack-like episodes over 2 period. Nodular enhancing leptomeningeal changes were detected on MRI consistent meningeal biopsy. The patient's nodular disease continued to progress regress clinically...