A5055795223- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Esophageal and GI Pathology
- Chemical Synthesis and Analysis
- Ovarian cancer diagnosis and treatment
- Urinary and Genital Oncology Studies
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Studies
- FOXO transcription factor regulation
- RNA Research and Splicing
- Effects of Radiation Exposure
- Bladder and Urothelial Cancer Treatments
- Heat shock proteins research
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Xi'an Jiaotong University
2015
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Since autophagy-related genes (ARGs) play a key role in pathogenesis many tumors, including ESCC, purpose this study to establish an prognostic risk signature based on ARGs expression profile, and provide new method for improving prediction clinical outcomes. We obtained profiles ESCC from public data (GSE53625) extracted portion ARGs. Differential analysis enrichment were performed confirm abnormal...
This study aimed to build up nomogram models evaluate overall survival (OS) and cancer-specific (CSS) in early-onset esophageal cancer (EOEC). Patients diagnosed with (EC) from 2004 2015 were extracted the Surveillance Epidemiology End Results (SEER) database. Clinicopathological characteristics of younger versus older patients compared, analysis was performed both groups. Independent related factors influencing prognosis EOEC identified by univariate multivariate Cox analysis, which...
Abstract Background Radiotherapy is a primary therapeutic modality for esophageal squamous cell carcinoma (ESCC), but its effectiveness still restricted due to the resistance of cancer cells radiation. Long non‐coding RNAs (lncRNAs) and N 6 ‐methyladenosine (m6A) have been shown play significant roles in tumour radioresistance. However, precise manifestation role m6A‐modified lncRNAs ESCC radioresistance remain unclear. Methods Bioinformatics analysis was conducted identify implicated ESCC....
Considering the significance of autophagy and long non-coding RNAs (lncRNAs) in biology esophageal squamous cell carcinoma (ESCC), present study aimed to identify a new autophagy-related lncRNA signature forecast clinical outcomes ESCC patients guide individualized treatment.The expression profiles were obtained from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) database. We extracted genes Human Autophagy Database identified lncRNAs through Spearman correlation analysis....
Abstract Background Radiotherapy is one of the main treatments for esophageal squamous cell carcinoma (ESCC), but its efficacy limited by radioresistance. MicroRNAs play a crucial role in posttranscriptional regulation, which linked to cancer response radiation. Methods We successfully established radioresistant line model using fractionated irradiation. qRT-PCR was adopted detect expression miR-4443 human normal lines, tumor cells, and cells. Next, CCK-8, colony formation, apoptosis, cycle...
Flap endonuclease‑1 (FEN1) is a key factor during the maintenance of genomic stability and protection against tumorigenesis. Since identification functional polymorphisms FEN1 (rs174538 rs4246215), numerous studies have evaluated association between two single‑nucleotide cancer risk. To derive more precise estimation, meta‑analysis was performed on rs4246215) Odds ratios (ORs) 95% confidence intervals (CIs) were used to estimate strength associations. Thirteen case‑control studies, including...
// Shan Huang 1 , Shuyu Zheng 2 Tuotuo Gong Hongbing Ma Yue Ke Songchuan Zhao 3 Wenyu Wang 4 Lijun Jia 5 and Xiaozhi Zhang Department of Radiotherapy, Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China First Spine Surgery, Honghui Health Science Center, Institute for Molecular Medicine Finland (FIMM), University Helsinki, Oncology, Correspondence to: Zhang, email: zhang9149@sina.com Keywords: esophageal cancer; aged 80 older; radiotherapy; survival; stage...
Ferroptosis and long non-coding RNA (lncRNA) expression signatures have been associated with the clinical progression immune-contexture of different solid tumors. The study aimed to identify a prognostic signature ferroptosis-related lncRNAs (falncRNAs) forecast immune scenery immunotherapy response in esophageal cancer (EC).Gene profiles EC were extracted from Cancer Genome Atlas (TCGA) database, genes downloaded FerrDb which identified differentially expressed falncRNAs (DEfalncRNAs) via...
Background Modern radiotherapy exemplified by intensity-modulated radiation therapy (IMRT) and volumetric modulated arc (VMAT), has transformed esophageal cancer treatment. Facing challenges in treating thoracic near vital organs, this study introduces a regression model-based decision support tool for the optimal selection of techniques. Methods We enrolled 106 patients diagnosed with locally advanced designed individualized IMRT VMAT plans each patient. Detailed dosimetric analysis was...
Abstract Radioresistance is a major obstacle for the therapy of esophageal squamous cell carcinoma (ESCC) and lead to poor prognosis. Ferroptosis supposed be responsible radioresistance. However, ferroptosis‐induced radioresistance in ESCC its related regulatory mechanisms are not yet fully understood. In this study, human line corresponding cells were irradiated with 6 megavolts (MV) X‐ray. It was showed that irradiation led less ferroptosis radioresistant as compared parental cells,...
To investigate the effects of thanatos-associated protein 11 (THAP11) on proliferation and apoptosis esophageal cancer cell underlying mechanism. Methods: Expression THAP11 in human epithelial cells (Het-1A) (Eca109, TE-1, Ec 9706) were detected by Western blotting. Esophageal TE-1 divided into 3 groups: a normal control (NC) group, negative (LV-NC) group (LV-THAP11) group. Then MTT assay, flow cytometry, caspase-3 caspase-9 levels caspases kits. Ubiquitination p53 was determined cells....
Abstract Objective This study aimed to investigate the effects of vitamin B12 mixed oral liquid in treatment radiation-induced esophagitis patients with esophageal cancer. Methods Seventy-five cancer who met enrollment criteria were randomly divided into group (39 group) and gentamicin (36 control group). The two methods on grading, pain degree, body weight loss, Karnofsky performance status (KPS) score radiation observed. Results In group, grade 1 accounted for 27.8% total patients, 2...
Abstract Objective We aimed to observe the radiosensitization effect of mir-30a-5p in a nude mouse model with subcutaneous lung-cancer xenograft and explore underlying mechanism. Methods A549 cell lines either stable upregulation or downregulation mir-30a-5p, their negative control, were transfected lentivirus vectors. These used establish xenograft. Each group was randomly divided into irradiated non-irradiated groups. The vivo studied by observing growth trends tumor weight. mechanisms...