A5039045671- Plant Reproductive Biology
- Reproductive System and Pregnancy
- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
University of California, San Diego
2021-2024
Abstract Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by elevated androgens and antimüllerian hormone (AMH). These hormones remain throughout pregnancy, potential effects of exposure on offspring from women with PCOS largely unexplored. Expanding recent reports prenatal AMH in mice, we have fully the consequences (pAMH) lifespan first- second-generation both sexes. We also sought to elucidate mechanisms underlying pAMH-induced effects. There known...
Abstract Disclosure: J. Cassin: None. R.D. Nguyen: K.J. Tonsfeldt: G.A. Dunn: V. Chen: S.E. Yeo: P.L. Mellon: Mutations in the SOX2 gene have been previously linked to a syndromic form of Isolated Hypogonadotropic Hypogonadism (IHH), with additional ocular and neurodevelopmental phenotypes. Recently, we published research detailing novel variants SOX2, which demonstrated functional role for Kisspeptin-expressing hypothalamic neurons, establishing mechanistic relationship between heterozygous...