A5103060322- Computational Drug Discovery Methods
- Diverse Scientific Research Studies
- Essential Oils and Antimicrobial Activity
- Drug-Induced Hepatotoxicity and Protection
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- COVID-19 Clinical Research Studies
- Toxin Mechanisms and Immunotoxins
- Medicinal Plant Research
- Mosquito-borne diseases and control
- Ethnobotanical and Medicinal Plants Studies
- Transgenic Plants and Applications
- Nigella sativa pharmacological applications
- Malaria Research and Control
- Long-Term Effects of COVID-19
- Phytochemistry and Bioactivity Studies
- Plant Virus Research Studies
- Plant-based Medicinal Research
- Pomegranate: compositions and health benefits
- Cassava research and cyanide
- Food Science and Nutritional Studies
- Piperaceae Chemical and Biological Studies
- Plant biochemistry and biosynthesis
- Vitamin C and Antioxidants Research
University of Development Alternative
2020-2022
University of Tasmania
2020
The focus of this roadmap is to evaluate the possible efficacy
Dengue is a Flavivirus infection transmitted through mosquitoes of the Aedes genus, which known to occur in over 100 countries world. has no available drugs for treatment; CYD-TDV only vaccine thus far approved use by few In absence and widely vaccine, attention been focused on plant-derived compounds discovery potential therapeutic DENV. The present study aimed determine, silico, binding energies steroidal saponins, melongosides, NS2B-NS3 activator protease DENV-2, plays an essential role...
Among the large number of plants that are part Ayurvedic system medicine in India and Bangladesh, Zingiber officinale Roscoe (Zingiberaceae), or ginger English, holds a special place is often referred to as “Mahaushadha” (great medicine) “Vishvabhesaja” (worldwide universal herb) signify its status. The plant particularly rhizomes used both raw dry form for relief multitude disorders. Since these disorders occur patients infected with severe acute respiratory syndrome coronavirus 2...
Aims: Corona virus SARS-CoV-2, otherwise known as COVID-19 has created a pandemic resulting in social and financial crisis throughout the world. The no drugs or vaccines for preventive therapeutic purposes. objective of present study was to screen phytochemicals from Cassia occidentalis L. virtual screening (in silico) studies evaluate their potential binding main 3C-like protease so stop its replication.
 Study Design: Molecular docking approach used studies.
 Place Duration...
The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle rainforest Malaysia, has not been studied. may produce antibacterial and antibiotic-potentiating metabolites. Hexane, chloroform, methanol extracts leaves, bark, wood, pericarps, endocarps were tested against bacteria by broth microdilution assay their activities. Chromatographic separations hexane seeds conducted to investigate effective phytochemicals Molecular docking...
COVID-19, caused by the coronavirus SARS-CoV-2, emerged in late December 2019 Wuhan, China. As of 8 April 2022, virus has a global pandemic, resulting 494,587,638 infections leading to 6,170,283 deaths around world. Although several vaccines have received emergency authorization from USA and UK drug authorities two more Russia China, it is too early comment on prolonged effectiveness vaccines, their availability, affordability for developing countries world, daunting task vaccinate 7 billion...
COVID-19, a coronavirus (SARS-CoV-2) caused disease has turned into pandemic with no therapeutics in the form of drugs or vaccines yet sight. The objective this study was to evaluate molecular docking studies binding energies b-sitosterol (a phytosterol) and some its fatty acid esters main protease otherwise known as 3C-like 3CLpro, (PDB ID: 6LU7) an attempt discover possible lead compounds against virus means contain pandemic. Molecular (blind) done help Autodock Vina. Seven major were...
The novel coronavirus known as SARS-CoV-2 and the virus-induced disease COVID-19 has caused widespread concerns due to its contagiousness, fatality rate, absence of drug(s). This study investigated Lens culinaris phytochemicals, especially flavonoids. compounds were assessed through molecular docking studies for their binding abilities with major protease coronavirus, (PDB : 6LU7). A total 42 phytochemicals analyzed affinities COVID 3C-like protease. Of them, 23 found have −7.5 kcal/mol or...
To evaluate the efficacy of reported anti-malarial phytochemicals as lead compounds for possible drug development against COVID-19.An in silico approach was used this study to determine through molecular docking binding affinities and site these 3C-like protease COVID-19 which is considered main virus.A number like apigenin-7-O-glucoside, decurvisine, luteolin- 7-O-glucoside, sargabolide J, shizukaols A, B, F, G showed predicted high energies with ΔG values -8.0 kcal/mol or higher....
The current pandemic of COVID-19 caused by the coronavirus SARS-CoV-2 has as December 2, 2020 resulted in 64,504,648 infected cases resulting 1,493,082 deaths. Although at least three vaccines against virus are on their way to get emergency approval from United States Food and Drug Administration possibly 15, 2020, this may not be final answer problem. Out vaccines, two needs low temperatures for storage facility available less developed countries. countries a position compete with regarding...
Forty-three phytochemicals present in Lens culinaris were evaluated through in-silico molecular docking studies for their binding affinities to the NS2B-NS3 activator-protease complex of dengue virus serotype 2 (DENV-2). Among various compounds tested, flavonoids (flavanols,favonols, proanthocyanidins, flavanones, flavones, and anthocyanins) demonstrated high protease complex. Eriodictyol-7-O-rutinoside showed least predicted energy at -9.1 kcal/mol followed by luteolin-7-O-glucoside -8.8...