Objectives Fibromyalgia syndrome (FMS) is a chronic disorder defined by widespread muscle pain and multiple tender points. The objectives of this study were to estimate prevalence comorbidities, healthcare resources utilization, costs associated with FMS. Methods A retrospective cohort was conducted using data from the Quebec provincial health plans (RAMQ) for random sample patients diagnoses FMS control without FMS, matched age gender. Prevalence comorbidities estimated. Healthcare consumed...

Cost-Utility Analysis of Imaging for Surveillance and Diagnosis Hepatocellular CarcinomaPaulo Henrique Lima1,2, Boyan Fan2, Joshua Bérubé2, Milena Cerny1,2, Damien Olivié2, Jeanne-Marie Giard3, Catherine Beauchemin4 An Tang1,2Audio Available | Share

Although high non-adherence to medication has been noticed for ulcerative colitis (UC), little is known about adherence mesalamine treatments and determinants that can predict adherence. The objective of this study was assess persistence their potential in mild moderate UC patients a real-life setting Quebec, Canada.A retrospective prescription medical claims analysis conducted using random sample users with UC. For inclusion, were required initiate an oral treatment between January 2005...

To understand attention-deficit/hyperactivity disorder (ADHD) treatment patterns and estimate adherence persistence in Quebec, Canada.This cross-sectional, retrospective prescription claims analysis used a random sample of 15 838 patients with ADHD from Quebec database (Régie de l'assurance maladie du Québec [RAMQ]) to assess patterns, (1-year medication possession ratio new users), (proportion persistent at 3, 6, 12 months after index prescription).The mean patient age was 14 years; 72.6%...

Dexmedetomidine is an α(2)-receptor agonist administered by continuous infusion in the intensive care unit (ICU) for sedation of critically ill patients who are undergoing mechanical ventilation following intubation. Relative to ICU receiving midazolam (a γ-aminobutyric acid agonist) sedation, those dexmedetomidine spent less time on ventilation, had fewer episodes delirium, and a lower incidence tachycardia hypertension.To assess economic impact, Canadian context, dexmedetomidine, relative...

The costs associated with the care of Alzheimer's disease patients are very high, particularly those nursing home placement. combination a cholinesterase inhibitor (ChEI) and memantine has been shown to significantly delay admission homes as compared treatment ChEI alone. objective this cost-effectiveness analysis was evaluate economic impact concomitant use Markov modelling used in order simulate transitions over time among three discrete health states (non-institutionalised,...

Objective Considering the increasing number of treatment options for metastatic breast cancer (MBC), it is important to develop high-quality methods assess cost-effectiveness new anti-cancer drugs. This study aims a global economic model that could be used as benchmark evaluation therapies MBC.Methods The Global Pharmacoeconomics Metastatic Breast Cancer (GPMBC) Markov was constructed estimate incremental cost per quality-adjusted life years (QALY) treatments MBC from Canadian healthcare...

The endpoints of progression-free survival (pfs) and time-to-progression (ttp) are frequently used to evaluate the clinical benefit anticancer drugs. However, surrogacy those for overall (os) is not validated in all cancer settings. In present study, we a trial-based approach assess relationship between median pfs or ttp os chronic lymphocytic leukemia (cll).The pico (population, interventions, comparators, outcomes) method was conduct systematic review literature. population consisted...

Risk of morbidity and mortality in patients with severe heart failure (HF) is reduced by blockade aldosterone receptors spironolactone. However, benefits spironolactone are potentially limited treatment compliance adverse events profile. The aim this study was to estimate use HF, incidence key events, patient compliance. This performed using data from the Quebec provincial medical drug plans (Régie de l'Assurance Maladie du Québec, RAMQ) for who had a diagnosis HF. Relative gynecomastia...

Progression-free survival (PFS) and time to progression (TTP) are frequently used establish the clinical efficacy of anti-cancer drugs. However, surrogacy PFS/TTP for overall (OS) remains a matter uncertainty in metastatic breast cancer (mBC). This study assessed relationship between OS mBC using trial-based approach.WE CONDUCTED A SYSTEMATIC LITERATURE REVIEW ACCORDING TO THE PICO METHOD: 'Population' consisted women with mBC; 'Interventions' 'Comparators' were standard treatments or best...

Objective: An observational study showed that combining memantine with a cholinesterase inhibitor (ChEI) treatment significantly delayed admission to nursing homes in patients Alzheimer disease (AD). Our aimed evaluate the economic impact of concomitant use and ChEI, compared ChEI alone, Canadian population AD. Method: A cost-utility analysis using Markov model during 7-year time horizon was performed according societal health care system perspective. The includes following states:...

Patients with Alzheimer disease (AD) show a high incidence of behavioural and psychological symptoms dementia, which often lead to the prescription antipsychotics. Our study sought assess impact initiation memantine or cholinesterase inhibitors (ChEIs) on use antipsychotics.A retrospective cohort was conducted using data from Quebec provincial health plan database. included in our had received diagnosis AD were initial users ChEIs. The proportion patients who used antipsychotics estimated...

Bipolar disorder (BPD) is prevalent and associated with a significant economic burden. Asenapine, the first tetracyclic antipsychotic approved in Canada for treatment of BPD, has shown comparable efficacy profile to other atypical antipsychotics. In addition, it favourable metabolic minimal weight gain potential. This study aimed assess impact asenapine compared olanzapine BPD Canada.A decision tree combined Markov model was constructed cost-utility olanzapine. The takes into account...

Asenapine is the first tetracyclic antipsychotic approved in Canada for treatment of schizophrenia (SCZ). has shown a comparable efficacy profile to other atypical antipsychotics and it associated with favourable metabolic less weight gain. This study aimed assess economic impact asenapine compared SCZ Canada.A decision tree combined Markov model was constructed cost-utility antipsychotics. The takes into account occurrence extrapyramidal symptoms, probability switching different...

Background: Continuous oral targeted therapy (OTT) for chronic lymphocytic leukemia (CLL) represents an effective but also a major economic burden on the healthcare system. This study aimed to estimate future direct costs, along with prevalence, of CLL in era continuous OTT Canada. Methods: The was modelled and compared chemoimmunotherapy (CIT), treatment. assessed/projected from 2011 2025. For scenario, CIT considered standard care before 2015, while patients either unmutated immunoglobulin...

Invasive mold infections (IMI) directly impact life expectancy, especially with delayed therapy. Among IMI, aspergillosis (IA) is more common than mucormycosis (IM), resulting in IA-targeted empirical treatment voriconazole for suspected invasive pulmonary (IPA), despite IM ineffectiveness. Recently, isavuconazole was approved Canada IA and IM. The primary objective to assess the cost-effectiveness of compared IPA Canada. A secondary varying time horizons address wide spectrum expectancies,...