Starch was extracted from bitter yam (Dioscorea dumetorum) and subsequently modified through esterification (succinylation) microwave treatment. The functional properties of the starches were then examined. Proximate composition analysis showed that, after modification, succinylated (OSABS) microwavetreated (MTBS) exhibited lower moisture content but higher levels protein, ash, crude fiber, fat compared to untreated starch (UBS). Both modifications substantially improved swelling power...

Purpose: To formulate double-coated insulin-loaded polymer-based microparticles (MPs) for oral delivery of insulin. Methods: Different formulations MPs were prepared using polyethylene glycol 4000 (PEG 4000) and chitosan as primary coat Eudragit® RL 100 secondary coating agents. Physicochemical characterization, in vitro drug release, toxicological, vivo studies diabetic rats performed, the results orally administered compared with those subcutaneously Humulin®. Results: The developed showed...

A simple, economic, rapid, reliable, and stability-indicating high-performance liquid chromatography (HPLC) method has been developed validated for the simultaneous determination of paracetamol (PCM) caffeine (CF) in solid dosage form. The chromatographic separations were achieved with a Waters Symmetry® C18 column (5 μm, 4.6 × 150 mm), using mixture methanol water (40:60, v/v) as mobile phase, under isocratic elution mode flow rate 0.8 mL/min, ultraviolet (UV) detection was set at 264 nm....

Abstract Background The aim of the study was to evaluate suitability triclosan (TCS) and flurbiprofen (FLB) with poly-ε-caprolactone (PCL), chitosan (CS), Kolliphor® P188 (KP) for possible application in design nano-formulations. Results Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), electron microscopy (SEM) revealed physical characteristics various sample compositions without any apparent interaction. Fourier transform infrared spectroscopy (FTIR)’s spectra...

Hibiscus sabdariffa L. (H.S.) plant and its calyces have received much attention from researchers because of their potential medicinal nutritional values. Calyces are the major source anthocyanin in this plant. Therefore, a well-developed, efficient, accurate analytical method is needed to assure proper standardization control quality H.S. herbal nutraceutical products. The objective work develop simple, rapid, stability-indicating HPLC-UV for quantitative determination spray-dried aqueous...

In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro vivo as carriers for the oral delivery insulin. Characterization measurements showed that insulin-loaded display irregular porosity shape. The encapsulation efficiency loading capacity insulin >82% 18%, respectively. release varied between 68% 92% depending on microparticle formulation. particular, orally administered resulted a significant fall blood glucose...

Formulation and Characterization of Dental Film Containing OfloxacinMd. Sajid Ali, Javed Alka Ahuja, Md. Sarfaraz Alam

Abstract Background Polypharmacy and potentially inappropriate medications (PIMs) could cause adverse drug events leading to poor health outcomes. This burden is addressed through deprescribing practice. However, data on practices are lacking in Nigeria, where the healthcare systems fragile. Aim review aimed summarise literature of polypharmacy PIMs identify need for practice Nigeria. Method A systematic search was conducted MEDLINE PubMed (Public Medline), Google Scholar, a manual included...

A new high-performance liquid chromatographic (HPLC) method for determination of triclosan (TCS) and flurbiprofen (FBP) was successfully developed validated at a single wavelength. The involves extraction the targeted drugs from nanogels simulated saliva by using methanol as extractant. Agilent ZORBAX SB-C18 column (5 μm, 4.6 × 250 mm) used separations. effects various parameters were extensively evaluated optimized. optimal HPLC conditions acetonitrile 0.001 M citric acid (90:10, v/v ) with...

Nanoparticles-Hydrogel Composite (nanogels) have yielded a surge in the design and development of novel drug delivery systems for treatment many ailments, including periodontal disease. The recent innovations nanotechnological carrier seem promising, as it provides means to improve bioavailability poorly soluble drugs, formulations controlled targeted systems, release control base on stimuli response, among others. Several polymeric nanoparticles-hydrogel co-formulations been investigated...

Counterfeit drugs (CDs) continue to cause serious public health problems in many countries around the globe, particularly African which are their major consumers. Soft penalties for drug counterfeiters; recent increase internet commerce; ignorance and lack of effective partnership between companies, regulatory agencies, law enforcement bodies, customs, among others, have contributed rise counterfeiting menace. However, governments at various levels some affected do not accede menace CDs, as...

The peril of substandard and falsified medicines (SFM) risk complete failure the United Nations Sustainable Development Goals on access to safe, effective, quality, affordable essential in African countries. global market volume SFM could be up US$200 billion, 70% total circulation some parts Africa. This dominance region is a clear sign proliferation, which continues cause avoidable health hazards leading severe adverse effects devastating loss human lives, by compromising treatment...

A combination of two drugs involving flurbiprofen (FLB) and triclosan (TCS) has been found to be potential treatment candidates against periodontal disease.In the present study, a new, simple, reliable stability-indicating high performance liquid chromatography (HPLC) method for simultaneous determination FLB TCS in dental nanogel (NGs) formulation introduced.The chromatographic fractionation was accomplished with Agilent ZORBAX SB-C18 column (5 µm, 4.6 × 250 mm), using mixture acetonitrile...

To evaluate therapeutic effectiveness of antibacterial triclosan (TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-induced experimental periodontitis rats.A total 72 Sprague-Dawley rats were used this study. Four groups (n = 18 each) randomly created: Group 1 - neither subjected to nor any treatment; 2 but not treated; 3 then treated with the developed nanogels; 4 placed on a mixture pure TCS FLB treatment. The was induced lower incisors by applying ligature...

Prosopis africana (Guill. & Perr.) is a perennial leguminous tree of the subfamily Mimosaidae and found to grow in savanna region Senegal Nigeria. Several parts plant has been documented possess ethno medicinal value. The study aimed determine phytochemical constituents using methods described by Trease Evans toxicity profile (using established determination protocols) methanol stem bark extract albino Wistar rats. Phytochemical screening revealed presence alkaloids, glycosides,...

Treatments for diarrhoeal and vomiting with modern drugs have been associated unwanted effects such as sedation extrapyramidal effects. In this study, Ficus thonningii Blume leaf extract (FTE) was investigated its anti-diarrhoeal anti-emetic properties. Two study groups, namely groups (n=36), were sorted into: placebo; drug-treatment, 3 plant-extract treatment (FT100, FT200 FT300) subgroups (n = 6). the placebo group, chicks administered only saline solution (0.9 %) while chlorpromazine (150...