A5101815275- Advanced Drug Delivery Systems
- Garlic and Onion Studies
- Pharmacological Effects of Natural Compounds
- Advancements in Transdermal Drug Delivery
- Polysaccharides Composition and Applications
- Drug Solubulity and Delivery Systems
- Botanical Research and Chemistry
- Drug-Induced Adverse Reactions
- Pharmaceutical studies and practices
- Natural Products and Biological Research
- African Botany and Ecology Studies
- Natural Antidiabetic Agents Studies
- Pineapple and bromelain studies
- Ocular Surface and Contact Lens
University of Nigeria
2016-2023
Purpose: To formulate double-coated insulin-loaded polymer-based microparticles (MPs) for oral delivery of insulin. Methods: Different formulations MPs were prepared using polyethylene glycol 4000 (PEG 4000) and chitosan as primary coat Eudragit® RL 100 secondary coating agents. Physicochemical characterization, in vitro drug release, toxicological, vivo studies diabetic rats performed, the results orally administered compared with those subcutaneously Humulin®. Results: The developed showed...
Allium cepa has been in use traditional medicine the treatment of diabetes mellitus. The aqueous and ethanolic extracts have found effective lowering blood glucose levels experimental diabetic rats guinea pigs.The study was carried out to isolate active principle responsible for observed hypoglycaemic effect animals. Freeze-dried extract separated into various fractions using column chromatography with silica gel as a stationary phase. eluted ratios mixtures hexane, chloroform, ethyl acetate...
The chemical quality of natural gum determines its functionality and safe use. This study was to characterize some physicochemical properties microbial load obtained from Dioclea reflexa seed (DR), which has a history folkloric use as soup thickener in eastern Nigeria. extracted by aqueous maceration DR. determined using the pour plate technique. extract screened for phytochemical constituents analyzed elemental content atomic absorption spectroscopy (AAS) scanning electron microscopy (SEM)....
The aim of this work was to formulate and evaluate the herbal tablets Allium cepa L. for in vitro tablet properties, hypoglycemic effects their on some biochemical parameters diabetic rats. Aqueous extract A. obtained by cold maceration freeze dried. compatibility with excipients assessed using Fourier transform infrared spectroscopy. consisted extract, gelatin, polyvinyl pyrrolidone (PVP), carboxymethyl cellulose (CMC), Primogel®, Ac-Di-Sol®, Avicel® PH102, anhydrous lactose,...
Purpose: To study the release behaviour of ciprofloxacin hydrochloride tablet matrices prepared with different polymers in dissolution media pH. Methods: Different formulations slow-release matrix tablets were polymers, namely, ethyl cellulose (Etc), hydroxyethyl (Hec), hydroxypropyl methylcellulose (Hpc), and Eudragit® L-100 (Eud) using embedding technique. The characterized studies their profiles studied 0.1 N HCl (pH 1.2) simulated intestinal fluid (excluding enzymes) pH 4.0, 6.0, 7.4....
Enhanced utilization of certain drugs may be possible through the development alternative delivery forms. It has been observed that NSAIDs have adverse gastrointestinal tract effects such as irritation and ulceration during anti-inflammatory therapy. This challenge overcome nano topical formulations.This study aimed to explore potentials a transdermal nanovesicular formulation for safe enhanced piroxicam (PRX), poorly water-soluble NSAID.Preformulation studies were conducted using DSC FTIR....
The aim of the work was to formulate piroxicam-loaded solid lipid microparticles (SLMs) using natural biodegradable lipids and evaluate in vitro vivo properties formulations.